Molly Clarke^1,*, Karin Hamann², Nancy Klein², Laura Olivieri³, Yue-Hin Loke²

Congenital Heart Disease, Vol.19, No.1, pp. 5-17, 2024, DOI:10.32604/chd.2024.046328

Abstract Background: Patients with congenital heart disease (CHD) will transition to lifelong adult congenital cardiac care. However, their structural heart disease is challenging to convey via two-dimensional drawings. This study utilized a tele-educational environment, with personalized three-dimensional (3D) modeling and health Details (3D + Details = “4D”), to improve actual and perceived knowledge, both important components of transition readiness in CHD patients. Methods: Participants aged ≥13 years with a history of CHD and cardiac magnetic resonance imaging (MRI) studies were eligible. Cardiac MRI datasets were then used to segment and create 3D heart models (using Mimics, Materialize Inc.). Participants first completed… More >

Qingzhuo Chi¹, Huimin Chen¹, Shiqi Yang¹, Lizhong Mu^1,*, Changjin Ji², Ying He¹, Yong Luan³

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 31-47, 2022, DOI:10.32604/cmes.2022.018286

Abstract Cardiovascular computational fluid dynamics (CFD) based on patient-specific modeling is increasingly used to predict changes in hemodynamic parameters before or after surgery/interventional treatment for aortic dissection (AD). This study investigated the effects of flow boundary conditions (BCs) on patient-specific aortic hemodynamics. We compared the changes in hemodynamic parameters in a type A dissection model and normal aortic model under different BCs: inflow from the auxiliary and truncated structures at aortic valve, pressure control and Windkessel model outflow conditions, and steady and unsteady inflow conditions. The auxiliary entrance remarkably enhanced the physiological authenticity of numerical simulations of flow in the ascending… More >

Mohamad Shukri Zakaria^1,*, Haslina Abdullah², Azmi Nordin¹, Syazwati Ahmad Zaki¹

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.1, pp. 171-179, 2021, DOI:10.32604/fdmp.2021.010974

Abstract This study deals with the interaction of blood flow with the wall aorta, i.e., the boundary of the main artery that transports blood in the human body. The problem is addressed in the framework of computational fluid dynamics complemented with (FSI), i.e., a fluid-structure interaction model. Two fundamental types of wall are considered, namely a flexible and a rigid boundary. The resulting hemodynamic flows are carefully compared in order to determine which boundary condition is more effective in reproducing reality. Special attention is paid to wall shear stress (WSS), a factor known for its ability to produce atherosclerosis and bulges.… More >

Shicheng He¹, Juhui Qiu¹, Wanling Liu¹, Tieying Yin¹, Dechuan Zhang^2,*, Donghua Liao^3,4, Haijun Zhang⁵, Yuxia Yin⁵, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.17, No.2, pp. 63-74, 2020, DOI:10.32604/mcb.2020.08750

Abstract Computational fluid dynamics (CFD) has been widely used for studying intracranial aneurysm hemodynamics, while its use for guiding clinical strategy is still in development. In this study, CFD simulations helped inform treatment decision for a middle cerebral artery (MCA) aneurysm case was investigated. A patient with a 10.4 × 9.8 mm aneurysm attached with a small aneurysm at the edge of the trifurcation in the left MCA was included in this study. For removing the MCA aneurysm, two scenarios were considered: Plan-A involved clipping the small aneurysm and Plan-B involved clipping the whole aneurysm. A suitable treatment plan was decided… More >

Xueying Huang^1,*, Long Deng², Chun Yang³, Mary Lesperance⁴, Dalin Tang⁵

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 58-58, 2019, DOI:10.32604/mcb.2019.06969

Abstract Hypertrophic cardiomyopathy (HCM) occurs in about 1 of every 500 adults in the general population. It has been reported that left ventricular outflow tract obstruction (LVOTO) is observed in 70% patients with HCM. Systolic anterior motion (SAM) of the mitral valve (MV) is the dominant cause of dynamic outflow tract obstruction in most patients with hypertrophic obstructive cardiomyopathy (HOCM). Currently, the hemodynamic mechanisms of SAM remain unclear. In this study, we developed 12 active and corresponding passive models based on 6 patients’ pre- and post-operative ECG-gated cardiac CT images of patients’ LV at the pre-SAM time point (5% RR interval).… More >

Ram P. Ghosh¹, Matteo Bianchi¹, Gil Marom², Oren M. Rotman¹, Brandon Kovarovic¹, Danny Bluestein^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 12-14, 2019, DOI:10.32604/mcb.2019.07379

Abstract This article has no abstract. More >

Qingyu Wang¹, Dalin Tang^1,2,*, Gador Canton³, Zheyang Wu², Thomas S. Hatsukami⁴, Kristen L Billiar⁵, Chun Yuan⁶

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 81-82, 2019, DOI:10.32604/mcb.2019.05748

Abstract This article has no abstract. More >

Xiaoya Guo¹, Dalin Tang^1,2,*, David Molony³, Chun Yang², Habib Samady³, Jie Zheng⁴, Gary S. Mintz⁵, Akiko Maehara⁵, Jian Zhu⁶, Genshan Ma⁶, Mitsuaki Matsumura⁵, Don P. Giddens^3,7

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 75-76, 2019, DOI:10.32604/mcb.2019.05743

Abstract Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. Plaque morphological information on intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images could complement each other and provide for more accurate plaque morphology. Fluid-structure interaction (FSI) models combining IVUS and OCT were constructed to obtain accurate plaque stress/strain and flow shear stress data for analysis. Accuracy and completeness of imaging and advanced modeling lead to accurate plaque progression predictions.
In vivo IVUS and OCT coronary plaque data at baseline and follow-up were acquired from left circumflex coronary and right coronary artery of one… More >

Guangyu Zhu¹, Yuan Wei¹, Qi Yuan^1,*, Ge Yan², Jian Yang²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 55-56, 2019, DOI:10.32604/mcb.2019.05730

Abstract This article has no abstract. More >

Lizhong Mu^{1, *}, Qingzhuo Chi¹, Changjin Ji², Ying He¹, Ge Gao³

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 175-197, 2018, DOI:10.31614/cmes.2018.04191

Abstract To improve aneurysm treatment, this study examined the influence of clip locations on hemodynamic factors in patient-specific anterior communicating artery (ACoA) aneurysms with different aneurysmal angle. We proposed a simplified classification of ACoA aneurysms using aneurysmal angle, defined by the angle of pivot of the aneurysmal dome and the virtual two-dimensional plane created by both proximal A2 segments of anterior cerebral artery (ACA). ACoA aneurysms with three different aneurysmal angles, which are 15°, 80° and 120°, were analyzed in our study. In this work, we obtained hemodynamics before and after clipping surgery with three clip locations based on clinical clipping… More >