JI ZENG^1,2,3,#, XUETENG MENG^1,3,#, YUAN ZHANG^1,3, JUN LI¹, TAOTAO MA^1,3,4, CHENG HUANG^1,3,*

Oncology Research, Vol.33, No.7, pp. 1739-1755, 2025, DOI:10.32604/or.2025.061978 - 26 June 2025

Abstract Background: Renal cell carcinoma (RCC) is a prevalent malignancy characterized by a rising incidence and significant mortality. Interleukins (ILs) are crucial in regulating immune cell trafficking and exhibit anti-tumor properties. However, limited research has explored the expression levels and prognostic significance of interleukins in RCC. Methods: In this comprehensive study, we performed a detailed analysis of interleukins in RCC patients using multiple bioinformatics tools, including Oncomine, UALCAN, GEPIA, Kaplan-Meier plotter, cBioPortal, GeneMANIA, TRRUST, STRING, and Linked Omics. Results: Our analysis demonstrated a significant upregulation in the transcriptional levels of IL4, IL7, IL15, IL16, IL23A, IL26, and… More >

YOUYANG HU^1,#, YISHU LUO^1,#, TIANYUE XIE¹, YUEHUA CHEN^1,2, JUN ZHAO¹, WEICHAO JI³, ZHIWEI YAN³, SITONG QIU³, KEXIN GAO³, HAIXIA ZHU⁴, LIMIN MA^1,*, QIYOU YIN^1,*

Oncology Research, Vol.33, No.7, pp. 1695-1708, 2025, DOI:10.32604/or.2025.060021 - 26 June 2025

Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >

LINGJIE XU¹, YIQIN XIA¹, QIN QIN¹, GUIQUN WANG¹, KAI TAO², WEI WEI^1,*

Oncology Research, Vol.33, No.7, pp. 1649-1666, 2025, DOI:10.32604/or.2025.056176 - 26 June 2025

Abstract Background: The centrosome, a crucial cellular structure involved in the mitotic process of eukaryotic cells, plays a significant role in tumor progression by regulating the growth and differentiation of neoplastic cells. This makes the centrosome a promising target for therapeutic strategies in cancer treatment. Methods: Utilizing data from the TCGA database, we identified centrosome-related genes and constructed a prognostic model for 518 lung adenocarcinoma patients. Prognosis-associated genes were initially screened using univariate Cox regression, with overfitting minimized by applying LASSO regression to remove collinearity. Finally, a set of 12 genes was selected through multivariable Cox… More >

Amrutanshu Panigrahi¹, Abhilash Pati¹, Bibhuprasad Sahu², Ashis Kumar Pati³, Subrata Chowdhury⁴, Khursheed Aurangzeb^5,*, Nadeem Javaid⁶, Sheraz Aslam^7,*

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1633-1657, 2025, DOI:10.32604/cmc.2025.063562 - 09 June 2025

Abstract The integration of IoT and Deep Learning (DL) has significantly advanced real-time health monitoring and predictive maintenance in prognostic and health management (PHM). Electrocardiograms (ECGs) are widely used for cardiovascular disease (CVD) diagnosis, but fluctuating signal patterns make classification challenging. Computer-assisted automated diagnostic tools that enhance ECG signal categorization using sophisticated algorithms and machine learning are helping healthcare practitioners manage greater patient populations. With this motivation, the study proposes a DL framework leveraging the PTB-XL ECG dataset to improve CVD diagnosis. Deep Transfer Learning (DTL) techniques extract features, followed by feature fusion to eliminate redundancy… More >

Yinghui Ye^1,#, Yulou Luo^2,#, Yutian Sun³, Yujie Zhang¹, Jiaxin Lin⁴, Ziling Yang⁵, Anping Xu^6,*, Bei Xue^1,*

Oncology Research, Vol.33, No.6, pp. 1383-1404, 2025, DOI:10.32604/or.2025.062584 - 29 May 2025

Abstract Objectives: The tumorigenic progression of Lung adenocarcinoma (LUAD), the predominant NSCLC subtype, is predominantly driven by co-occurring mutations in KRAS proto-oncogene (KRAS)/Tumor protein p53 (TP53). However, their impact on tumor microenvironment (TME) heterogeneity, particularly neutrophil dynamics, remains poorly understood. This present study aims to elucidate how KRAS/TP53 mutations reprogram the TME and develop a neutrophil-centric prognostic signature for LUAD. Methods: Leveraging single-cell RNA sequencing data and transcriptome data, neutrophil subpopulations were identified using Seurat and CellChat R packages, with trajectory analysis via Monocle2 R package. High-dimensional weighted gene co-expression network analysis (hdWGCNA), univariate Cox regression,… More >

KE TIAN¹, ZHIPENG LI², XIANGYU ZHAI^2,3, HUAXIN ZHOU², HUI YAO^1,*

Oncology Research, Vol.33, No.3, pp. 617-630, 2025, DOI:10.32604/or.2024.049772 - 28 February 2025

Abstract Background: Primary liver cancer poses a significant global health burden, with projections indicating a surpassing of one million cases by 2025. Cuproptosis, a copper-dependent mechanism of cell death, plays a crucial role in the pathogenesis, progression, and prognosis of various cancers, including hepatocellular carcinoma (HCC). Purpose: This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes, utilizing clinical data and gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Materials and Methods: Clinical features and gene expression data of HCC patients were collected from publicly available More >

PIAO YANG¹, MOHSEN SHEYKHHASAN^2,*, REZA HEIDARI³, MOHSEN CHAMANARA^4,5, PAOLA DAMA⁶, AMIRHOSSEIN AHMADIEH-YAZDI⁷, HAMED MANOOCHEHRI⁸, HAMID TANZADEHPANAH⁹, HANIE MAHAKI¹⁰, NASER KALHOR¹¹, ASHKAN DIRBAZIYAN¹², SHARAFALDIN AL-MUSAWI¹³

Oncology Research, Vol.33, No.2, pp. 283-300, 2025, DOI:10.32604/or.2024.052939 - 16 January 2025

Abstract Cancer, a leading cause of global mortality, remains a significant challenge to increasing life expectancy worldwide. Forkhead Box R2 (FOXR2), identified as an oncogene within the FOX gene family, plays a crucial role in developing various endoderm-derived organs. Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases. Dysregulation of FOXR2 has been linked to numerous malignant tumors, spanning the brain, nervous system, thyroid, osteosarcoma, Hodgkin lymphoma, colorectal, liver, pancreatic, lung, breast, ovarian, prostate, female genital tract, endometrial, and uterine cancers. Despite extensive research on FOXR2 dysregulation, its practical applications More >

TIANYUN ZHU^1,2,#, CUNYAN ZHAO^1,2,#, RUI GONG^1,2, AO QIAN¹, XIAOSHU WANG¹, FANGHUI LU², GANG HUO¹, LIANGJUN QIAO³, SONG CHEN^1,*

Oncology Research, Vol.33, No.2, pp. 431-442, 2025, DOI:10.32604/or.2024.050794 - 16 January 2025

Abstract Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored. Methods: We analyzed PLK3 expression in glioma samples from multiple databases. Both overexpression and knockdown of Plk3 were performed to investigate tumor cell growth in glioma, and the transplanted glioma mouse model demonstrated the role of Plk3 on tumor progression. Immunohistochemistry was conducted to detect PLK3 expression and immune cell infiltration. The trans-well assay for PLK3 on the immune… More >

YUEZHOU ZHANG^1,#, ZHAO ZHANG^2,#, JINXIN DONG¹, CHANGAN LIU^1,*

Oncology Research, Vol.33, No.1, pp. 83-102, 2025, DOI:10.32604/or.2024.055866 - 20 December 2024

Abstract Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized. Methods: We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental… More > Graphic Abstract

ATIEH POURBAGHERI-SIGAROODI¹, MAJID MOMENY², NIMA REZAEI^3,4,5, FATEMEH FALLAH^1,*, DAVOOD BASHASH^6,*

BIOCELL, Vol.48, No.12, pp. 1781-1804, 2024, DOI:10.32604/biocell.2024.055848 - 30 December 2024

Abstract Background: Despite progress in therapeutic strategies, treatment failure in hepatocellular carcinoma (HCC) remains a major challenge, resulting in low survival rates. The presence of bacteria and the host’s immune response to bacteria can influence the pathogenesis and progression of HCC. We developed a risk model based on bacterial response-related genes (BRGs) using gene sets from molecular signature databases to identify new markers for predicting HCC outcomes and categorizing patients into different risk groups. Methods: The data from the Cancer Genome Atlas (TCGA) portal was retrieved, and differentially expressed BRGs were identified. Uni- and multivariate Cox… More >