Kyungeun Kim^1,2,#, Eunho Cho^3,#, Eun Joo Chung⁴, Kwon-Ho Song⁵, Tae Woo Kim^3,6, Seoung Wan Chae^1,*, Joon-Yong Chung^7,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.083437 - 13 August 2026

Abstract Objectives: Gastric cancer remains a major global health burden, and robust biomarkers are needed to improve risk stratification. Although peptidyl-prolyl isomerase B (PPIB) has been suggested as a potential oncogenic factor, its clinical utility in gastric cancer remains unclear. This study aims to evaluate the clinicopathological and prognostic significance of PPIB mRNA expression and delineate its functional role in driving tumor progression. Methods: PPIB mRNA expression was evaluated in a retrospective cohort of 497 gastric cancer patients using RNAscope in situ hybridization and digital image analysis. Functional roles and underlying mechanism were assessed through siRNA-mediated knockdown, plasmid-driven overexpression,… More >

Carlo Signorelli^1,*, Michele Basso², Annunziato Anghelone², Maria Alessandra Calegari², Alessandro Passardi³, Chiara Gallio³, Alessandro Bittoni³, Jessica Lucchetti⁴, Lorenzo Angotti⁴, Emanuela Di Giacomo⁴, Ina Valeria Zurlo⁵, Cristina Morelli⁶, Emanuela Dell’Aquila⁷, Adele Artemi⁷, Donatello Gemma⁸, Domenico Cristiano Corsi⁹, Alessandra Emiliani⁹, Marta Ribelli⁹, Federica Mazzuca¹⁰, Giulia Arrivi¹⁰, Federica Zoratto¹¹, Maria Grazia Morandi¹², Fiorenza Santamaria^13,14, Manuela Dettori¹⁵, Antonella Cosimati¹⁶, Rosa Saltarelli¹⁷, Alessandro Minelli¹⁸, Emanuela Lucci-Cordisco¹⁹, Mario Giovanni Chilelli¹

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.080964 - 13 August 2026

Abstract Background: Trifluridine/tipiracil (T) is a standard treatment for refractory metastatic colorectal cancer (mCRC). In randomized trials, treatment-emergent neutropenia has been associated with improved outcomes, suggesting a potential link with drug activity. However, evidence from routine clinical practice remains limited. This sub-analysis of the multicenter ReTrITA study evaluated the association between severe neutropenia and clinical outcomes in a real-world setting. Methods: Patients with refractory mCRC treated with T within the ReTrITA cohort were included. Patients were stratified according to the occurrence of grade 3–4 neutropenia. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan–Meier… More >

Emmanuel Naveen Raj^1,#, Chia-Jung Li^1,2,3,4,5,#, Shih-Hsuan Cheng¹, Su-Boon Yong^6,7, Zhi-Hong Wen^3,8, An-Jen Chiang^1,9,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.079551 - 13 August 2026

Abstract Objectives: Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) necessitate the discovery of novel biomarkers for prognostic and therapeutic advancement. This study aims to evaluate the clinical significance of ubiquitin-conjugating enzyme E2C (UBE2C) and its association with the tumor microenvironment (TME) in CESC. Methods: We meticulously sourced CESC data from renowned repositories such as The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO), leveraging cutting-edge techniques including single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and pharmacogenomics. Through multifaceted data analysis, we endeavored to unravel the intricate role and potential value of UBE2C in… More > Graphic Abstract

Mohammad Muzaffar Mir^1,*, Rashid Mir^2,3, Badr A. Alsayed⁴, Mohammed M. Jalal³, Malik A. Altayar³, Hanan M. Aljammaz⁵, Zinab Alatawi⁶, Khalid A. Alfifi², Basmah M. Alenzi⁷, Mohammad Tanveer Khaji⁸, Umair Ismail⁹, Ghada Mohamed^10,11, Nada Zai Sageer¹², Abdullatif Taha Babakr¹³, Saba M. Mir¹⁴, Ulfat Jan¹⁵

BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.077540 - 27 July 2026

Abstract The tuberculosis (TB) epidemic continues to be one of the largest public health challenges affecting people globally, especially due to late diagnosis, disease monitoring, and prognosis. Currently used diagnostic tools have variable sensitivity and accessibility, and many have limited ability to differentiate between latent and active TB. In case of TB, exosomes from cells infected with Mycobacterium tuberculosis (M. tuberculosis) have disease-specific antigens, microRNAs, and other molecular components, which make them potential diagnostic and prognostic biomarkers. This review focuses on previously published literature regarding the role of exosomes and exosomal antigens in TB screening and prognostication. It… More >

Bin Lan¹, Jie Tan¹, Qing Wang¹, Siyuan Zeng^2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.081711 - 16 July 2026

Abstract Backgrounds: Cyclin-dependent kinase 7 (CDK7) plays key roles in transcription and cell cycle regulation, and its inhibition has been proposed as a potential therapeutic strategy for hepatocellular carcinoma (HCC). The primary research objective of this study is to identify and validate CDK7-associated prognostic genes in HCC using bioinformatics approaches, construct a reliable prognostic risk model, and explore the functional role of CDK7 in HCC progression through in vitro and in vivo experiments, with a specific focus on its association with RelA/p65 phosphorylation, so as to provide evidence supporting CDK7 as a potential prognostic biomarker and therapeutic target for… More >

Yiming Ma^1,2,#, Zhihan Zhang^1,2,#, Hongli Pan³, Hailin Jiang^1,2, Lili Guo^4,*, Fengjie Guo^1,2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.079515 - 16 July 2026

Abstract Objectives: Lung adenocarcinoma (LUAD) has a poor prognosis, and effective metabolic biomarkers are still few. Glutamine metabolism is one of the central features of tumor metabolic reprogramming, but the cellular heterogeneity and clinical significance of glutamine metabolism in the LUAD tumor microenvironment (TME) remain unknown. The goal of this paper was to define glutamine metabolism on a single-cell basis and determine major regulators that have predictive value. Methods: A single-cell RNA sequencing dataset (GSE149655) was combined with The Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) and Gene Expression Omnibus (GEO) datasets in order to evaluate the… More >

Wei Lee¹, Hung-Yu Lin^1,2,*, Pei-Yi Chu^1,3,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.078813 - 16 July 2026

Abstract Background: Guanylate kinase 1 (GUK1) is crucial for nucleotide metabolism, yet its impact on breast cancer (BC) progression remains poorly defined. The objective of the present study is to investigate GUK1 as a prognostic biomarker and therapeutic target. Methods: We employed a multi-omics approach integrating The Cancer Genome Atlas (TCGA) data, machine learning algorithm, High-Definition spatial transcriptomics (Visium HD), single-cell profiling, molecular docking and experimental validation including in vitro knockdown models and Surface Plasmon Resonance (SPR). Results: LASSO regression identified GUK1 as a key metabolic driver. High expression correlated significantly with poor survival and was most pronounced in… More >

Hsing-Ju Wu^1,2, Yu-Chieh Tsai^3,*, Hung-Yu Lin^2,4,*

European Cytokine Network, Vol.37, No.2, pp. 121-135, 2026, DOI:10.32604/ecn.2026.079012 - 30 June 2026

Abstract Backgrounds: Lymph node metastasis is a critical determinant of breast cancer prognosis, yet the specific microenvironmental cytokines driving this process remain elusive. This study aims to identify key prognostic cytokines linking nodal metastasis to tumor microenvironment (TME) remodeling and to evaluate their clinical utility. Methods: A predefined panel of 176 microenvironmental genes was evaluated using differential expression analysis and the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm on the TCGA-BRCA cohort to identify optimal predictors of nodal metastasis. Prognostic value was assessed via Kaplan-Meier, subgroup, and multivariate Cox regression analyses, and validated across five… More > Graphic Abstract

Ouail Mjahed^1,*, Soukaina Mjahed²

CMES-Computer Modeling in Engineering & Sciences, Vol.147, No.3, 2026, DOI:10.32604/cmes.2026.083272 - 30 June 2026

Abstract Accurate aircraft engine diagnostics is essential for ensuring operational safety and enabling predictive maintenance under heterogeneous operating conditions. Although deep learning models can effectively capture high-dimensional multivariate sensor dynamics, purely data-driven approaches often entangle operating-condition variability with degradation-sensitive patterns, which limits robustness and generalization. This paper introduces PRIME, a physics-guided residual integrated framework for multi-task aircraft engine diagnostics. Rather than embedding explicit thermodynamic equations or physical constraints into the optimization process, PRIME relies on a physically motivated residual decomposition strategy that separates operating-condition-driven nominal behavior from degradation-sensitive sensor deviations. Specifically, nominal responses are estimated from operating-condition… More >

Irene Bernal-Florindo^1,2, Jose Angel Raposo-Puglia^2,3, Felix A. Ruiz^2,4, Jose Perez-Requena^2,5, Cristian Benavides-de la Fuente^2,5, Javier Galan^2,6, Maria Jose Berruezo-Salazar^2,7, Marcial Garcia-Rojo^1,2, Cecilia Fernandez-Ponce^2,4,*, Antonio Santisteban-Espejo^2,8

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.079403 - 16 June 2026

Abstract Classic Hodgkin lymphoma (CHL) constitutes a B-cell malignant lymphoid neoplasm derived from the germinal center. Despite current treatment protocols based on chemotherapy, radiotherapy, anti-cluster of differentiation (CD) 30 antibody-drug conjugates, immunotherapy, and hematopoietic stem cell transplantation (HSCT), between 10% and 20% of CHL patients fail to achieve a complete response. The reasons underlying this lack of treatment sensitivity remain unclear. Traditionally, clinical and analytical variables have constituted the cornerstone of CHL prognostic model development. However, in recent years, the distribution and spatial relationships of cancer and immune cells within the CHL tumor microenvironment (TME) have… More >