Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (97)
  • Open Access

    ARTICLE

    IL1A: a novel prognostic biomarker and potential therapeutic target for renal clear cell carcinoma

    JI ZENG1,2,3,#, XUETENG MENG1,3,#, YUAN ZHANG1,3, JUN LI1, TAOTAO MA1,3,4, CHENG HUANG1,3,*

    Oncology Research, Vol.33, No.7, pp. 1739-1755, 2025, DOI:10.32604/or.2025.061978 - 26 June 2025

    Abstract Background: Renal cell carcinoma (RCC) is a prevalent malignancy characterized by a rising incidence and significant mortality. Interleukins (ILs) are crucial in regulating immune cell trafficking and exhibit anti-tumor properties. However, limited research has explored the expression levels and prognostic significance of interleukins in RCC. Methods: In this comprehensive study, we performed a detailed analysis of interleukins in RCC patients using multiple bioinformatics tools, including Oncomine, UALCAN, GEPIA, Kaplan-Meier plotter, cBioPortal, GeneMANIA, TRRUST, STRING, and Linked Omics. Results: Our analysis demonstrated a significant upregulation in the transcriptional levels of IL4, IL7, IL15, IL16, IL23A, IL26, and… More >

  • Open Access

    ARTICLE

    Correlation of senescence-related gene FEN1 on neuroblastoma progression and cisplatin chemotherapy sensitivity

    YOUYANG HU1,#, YISHU LUO1,#, TIANYUE XIE1, YUEHUA CHEN1,2, JUN ZHAO1, WEICHAO JI3, ZHIWEI YAN3, SITONG QIU3, KEXIN GAO3, HAIXIA ZHU4, LIMIN MA1,*, QIYOU YIN1,*

    Oncology Research, Vol.33, No.7, pp. 1695-1708, 2025, DOI:10.32604/or.2025.060021 - 26 June 2025

    Abstract Objective: Neuroblastoma (NB) is frequently associated with high-risk pediatric cases that demonstrate limited response to cisplatin, contributing to a poor prognosis. Recent studies have explored the role of tumor cell senescence in increasing sensitivity to this chemotherapy agent. This study aims to identify genes related to cell senescence in children diagnosed with NB, evaluate their influence on cisplatin sensitivity, and investigate potential strategies to enhance the efficacy of chemotherapy. Methods: Gene expression profiles and clinical data were obtained for 498 NB patients from the GEO database (GSE49710). The study focused on identifying genes that were… More >

  • Open Access

    ARTICLE

    Developing a prognostic signature and characterizing the tumor microenvironment based on centrosome-related genes in lung adenocarcinoma

    LINGJIE XU1, YIQIN XIA1, QIN QIN1, GUIQUN WANG1, KAI TAO2, WEI WEI1,*

    Oncology Research, Vol.33, No.7, pp. 1649-1666, 2025, DOI:10.32604/or.2025.056176 - 26 June 2025

    Abstract Background: The centrosome, a crucial cellular structure involved in the mitotic process of eukaryotic cells, plays a significant role in tumor progression by regulating the growth and differentiation of neoplastic cells. This makes the centrosome a promising target for therapeutic strategies in cancer treatment. Methods: Utilizing data from the TCGA database, we identified centrosome-related genes and constructed a prognostic model for 518 lung adenocarcinoma patients. Prognosis-associated genes were initially screened using univariate Cox regression, with overfitting minimized by applying LASSO regression to remove collinearity. Finally, a set of 12 genes was selected through multivariable Cox… More >

  • Open Access

    ARTICLE

    Advanced ECG Signal Analysis for Cardiovascular Disease Diagnosis Using AVOA Optimized Ensembled Deep Transfer Learning Approaches

    Amrutanshu Panigrahi1, Abhilash Pati1, Bibhuprasad Sahu2, Ashis Kumar Pati3, Subrata Chowdhury4, Khursheed Aurangzeb5,*, Nadeem Javaid6, Sheraz Aslam7,*

    CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1633-1657, 2025, DOI:10.32604/cmc.2025.063562 - 09 June 2025

    Abstract The integration of IoT and Deep Learning (DL) has significantly advanced real-time health monitoring and predictive maintenance in prognostic and health management (PHM). Electrocardiograms (ECGs) are widely used for cardiovascular disease (CVD) diagnosis, but fluctuating signal patterns make classification challenging. Computer-assisted automated diagnostic tools that enhance ECG signal categorization using sophisticated algorithms and machine learning are helping healthcare practitioners manage greater patient populations. With this motivation, the study proposes a DL framework leveraging the PTB-XL ECG dataset to improve CVD diagnosis. Deep Transfer Learning (DTL) techniques extract features, followed by feature fusion to eliminate redundancy… More >

  • Open Access

    ARTICLE

    Single-Cell Transcriptomic Profiling Reveals KRAS/TP53-Driven Neutrophil Reprogramming in Luad: A Multi-Gene Prognostic Model and Therapeutic Targeting of RHOV

    Yinghui Ye1,#, Yulou Luo2,#, Yutian Sun3, Yujie Zhang1, Jiaxin Lin4, Ziling Yang5, Anping Xu6,*, Bei Xue1,*

    Oncology Research, Vol.33, No.6, pp. 1383-1404, 2025, DOI:10.32604/or.2025.062584 - 29 May 2025

    Abstract Objectives: The tumorigenic progression of Lung adenocarcinoma (LUAD), the predominant NSCLC subtype, is predominantly driven by co-occurring mutations in KRAS proto-oncogene (KRAS)/Tumor protein p53 (TP53). However, their impact on tumor microenvironment (TME) heterogeneity, particularly neutrophil dynamics, remains poorly understood. This present study aims to elucidate how KRAS/TP53 mutations reprogram the TME and develop a neutrophil-centric prognostic signature for LUAD. Methods: Leveraging single-cell RNA sequencing data and transcriptome data, neutrophil subpopulations were identified using Seurat and CellChat R packages, with trajectory analysis via Monocle2 R package. High-dimensional weighted gene co-expression network analysis (hdWGCNA), univariate Cox regression,… More >

  • Open Access

    ARTICLE

    A novel prognostic scoring model based on cuproptosis identifies COMMD1 as a novel therapy target for liver hepatocellular carcinoma

    KE TIAN1, ZHIPENG LI2, XIANGYU ZHAI2,3, HUAXIN ZHOU2, HUI YAO1,*

    Oncology Research, Vol.33, No.3, pp. 617-630, 2025, DOI:10.32604/or.2024.049772 - 28 February 2025

    Abstract Background: Primary liver cancer poses a significant global health burden, with projections indicating a surpassing of one million cases by 2025. Cuproptosis, a copper-dependent mechanism of cell death, plays a crucial role in the pathogenesis, progression, and prognosis of various cancers, including hepatocellular carcinoma (HCC). Purpose: This study aimed to develop a prognostic model for HCC based on cuproptosis-related genes, utilizing clinical data and gene expression profiles from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Materials and Methods: Clinical features and gene expression data of HCC patients were collected from publicly available More >

  • Open Access

    REVIEW

    FOXR2 in cancer development: emerging player and therapeutic opportunities

    PIAO YANG1, MOHSEN SHEYKHHASAN2,*, REZA HEIDARI3, MOHSEN CHAMANARA4,5, PAOLA DAMA6, AMIRHOSSEIN AHMADIEH-YAZDI7, HAMED MANOOCHEHRI8, HAMID TANZADEHPANAH9, HANIE MAHAKI10, NASER KALHOR11, ASHKAN DIRBAZIYAN12, SHARAFALDIN AL-MUSAWI13

    Oncology Research, Vol.33, No.2, pp. 283-300, 2025, DOI:10.32604/or.2024.052939 - 16 January 2025

    Abstract Cancer, a leading cause of global mortality, remains a significant challenge to increasing life expectancy worldwide. Forkhead Box R2 (FOXR2), identified as an oncogene within the FOX gene family, plays a crucial role in developing various endoderm-derived organs. Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases. Dysregulation of FOXR2 has been linked to numerous malignant tumors, spanning the brain, nervous system, thyroid, osteosarcoma, Hodgkin lymphoma, colorectal, liver, pancreatic, lung, breast, ovarian, prostate, female genital tract, endometrial, and uterine cancers. Despite extensive research on FOXR2 dysregulation, its practical applications More >

  • Open Access

    ARTICLE

    Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma

    TIANYUN ZHU1,2,#, CUNYAN ZHAO1,2,#, RUI GONG1,2, AO QIAN1, XIAOSHU WANG1, FANGHUI LU2, GANG HUO1, LIANGJUN QIAO3, SONG CHEN1,*

    Oncology Research, Vol.33, No.2, pp. 431-442, 2025, DOI:10.32604/or.2024.050794 - 16 January 2025

    Abstract Background: PLK3, which played an important role in cell cycle progression and stress response, was identified as highly expressed in various carcinomas. However, the functions, molecular characteristics, and prognostic value of PLK3 in glioma remained unexplored. Methods: We analyzed PLK3 expression in glioma samples from multiple databases. Both overexpression and knockdown of Plk3 were performed to investigate tumor cell growth in glioma, and the transplanted glioma mouse model demonstrated the role of Plk3 on tumor progression. Immunohistochemistry was conducted to detect PLK3 expression and immune cell infiltration. The trans-well assay for PLK3 on the immune… More >

  • Open Access

    ARTICLE

    HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

    YUEZHOU ZHANG1,#, ZHAO ZHANG2,#, JINXIN DONG1, CHANGAN LIU1,*

    Oncology Research, Vol.33, No.1, pp. 83-102, 2025, DOI:10.32604/or.2024.055866 - 20 December 2024

    Abstract Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized. Methods: We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental… More > Graphic Abstract

    HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation

  • Open Access

    ARTICLE

    Unveiling the predictive power of bacterial response-related genes signature in hepatocellular carcinoma: with bioinformatics analyses and experimental approaches

    ATIEH POURBAGHERI-SIGAROODI1, MAJID MOMENY2, NIMA REZAEI3,4,5, FATEMEH FALLAH1,*, DAVOOD BASHASH6,*

    BIOCELL, Vol.48, No.12, pp. 1781-1804, 2024, DOI:10.32604/biocell.2024.055848 - 30 December 2024

    Abstract Background: Despite progress in therapeutic strategies, treatment failure in hepatocellular carcinoma (HCC) remains a major challenge, resulting in low survival rates. The presence of bacteria and the host’s immune response to bacteria can influence the pathogenesis and progression of HCC. We developed a risk model based on bacterial response-related genes (BRGs) using gene sets from molecular signature databases to identify new markers for predicting HCC outcomes and categorizing patients into different risk groups. Methods: The data from the Cancer Genome Atlas (TCGA) portal was retrieved, and differentially expressed BRGs were identified. Uni- and multivariate Cox… More >

Displaying 1-10 on page 1 of 97. Per Page