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  • Open Access


    Aortic stenting in the growing sheep causes aortic endothelial dysfunction but not hypertension: Clinical implications for coarctation repair

    Nicola Maschietto1, Luca Semplicini2, Giulio Ceolotto2, Arianna Cattelan2, Helen Poser3, Ilaria Iacopetti3, Gabriele Gerardi3, Giulia Maria De Benedictis3, Tommaso Pilla3, Daniele Bernardini3, Luca Aresu4, Stefania Rizzo5, Cristina Basso5, Andrea Semplicini2, Ornella Milanesi1

    Congenital Heart Disease, Vol.12, No.1, pp. 74-83, 2017

    Abstract Background: Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%–40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate response of the aortic baroreceptors to increased stiffness of the ascending aorta (ASAO), either congenital or induced by CoAo repair. In particular, it has been hypothesized that stent itself may cause or sustain hypertension. Therefore, we aimed to study the hemodynamic and structural impact following stent implantation in the normal aorta of a growing animal.
    Methods: Eight female sheep completed the study and a stent… More >

  • Open Access


    Endothelial Tight Junction Protein ZO-1 Response to Multiple-Mechanical Stimulations After Stent Implamtation

    Yang Wang1, Shuang Ge1, Junyang Huang1, Ruolin Du1, Tieying Yin1, Guixue Wang1,*, Yazhou Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 140-141, 2019, DOI:10.32604/mcb.2019.07300

    Abstract Zonula occludens-1 (ZO-1) is a peripheral membrane protein belongs to the family of zona occludens proteins and plays an important role as a scaffold protein which cross-links and anchors tight junction (TJ) strand proteins, within the lipid bilayer, to the actin cytoskeleton[1-2]. Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy junctions of endothelial cells, the functions of the tight junction were also affected. However, the role of ZO-1 before and after stent implantation has not been fully understood. In this study, the expression of ZO-1 were analyzed by qPCR, western blot and… More >

  • Open Access


    Expression of Endothelial Tight Junction Protein Occludin under Mechanical Factors after Stent Implantation

    Junyang Huang1, Shuang Ge1, Yang Wang1, Ruolin Du1, Yazhou Wang1, Tieying Yin1, Guixue Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 138-139, 2019, DOI:10.32604/mcb.2019.07305

    Abstract Tight junctions are the most apical intercellular junctions of the lateral membrane in endothelial cells, regulating the paracellular material and energy exchange and maintain plasma membrane polarity. Occludin protein is one of the important proteins involved in endothelial tight junctions, and also closely related to the occurrence of atherosclerosis. Therefore, the study of occludin is valuable [1]. With the implantation of coronary stents, the integrity of the vascular endothelium is damaged and the local mechanical environment at the stent segment was changed [2]. The present study tried to explore the impact of mechanical stimulation after stent implantation on the expression… More >

  • Open Access


    Mechano Growth Factor (MGF) Expression and Response to Multiple-Mechanical Stimulation after Biodegradable Stent Implantation

    Shuang Ge1, Ruolin Du1, Yuhua Huang1, Guixue Wang1, Yazhou Wang1, Tieying Yin1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 136-137, 2019, DOI:10.32604/mcb.2019.07317

    Abstract Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy the integrity of the vascular endothelium and the local mechanical environment at the stent segment was changed, especially the biodegradable stents [1]. In this study, 3D printed biodegradable poly (L-lactic acid) stents were implanted into SD rat abdominal aorta and the endothelialization, intimal hyperplasia, and MGF after stent implantation were studied. Besides, based on the MGF we explored the effects of mechanical stimulation on MGF express in vascular endothelial cells and smooth muscle cells, and also the effects of MGF with different concentrations on… More >

  • Open Access


    Numerical Investigation of the Hemodynamics Characteristics in Coronary Bifurcation Region with Different Dual Stent Implantation Techniques

    Guangyu Zhu1, Wei Cai2,*, Qi Yuan1, Lianglong Chen2

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 59-60, 2019, DOI:10.32604/mcb.2019.05733

    Abstract This article has no abstract. More >

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