Nicola Maschietto¹, Luca Semplicini², Giulio Ceolotto², Arianna Cattelan², Helen Poser³, Ilaria Iacopetti³, Gabriele Gerardi³, Giulia Maria De Benedictis³, Tommaso Pilla³, Daniele Bernardini³, Luca Aresu⁴, Stefania Rizzo⁵, Cristina Basso⁵, Andrea Semplicini², Ornella Milanesi¹

Congenital Heart Disease, Vol.12, No.1, pp. 74-83, 2017

Abstract Background: Stent implantation is the treatment of choice for adolescents and adults with aortic coarctation (CoAo). Despite excellent short-term results, 20%–40% of the patients develop arterial hypertension later in life, which was attributed to inappropriate response of the aortic baroreceptors to increased stiffness of the ascending aorta (ASAO), either congenital or induced by CoAo repair. In particular, it has been hypothesized that stent itself may cause or sustain hypertension. Therefore, we aimed to study the hemodynamic and structural impact following stent implantation in the normal aorta of a growing animal.
Methods: Eight female sheep completed the study and a stent… More >

Yang Wang¹, Shuang Ge¹, Junyang Huang¹, Ruolin Du¹, Tieying Yin¹, Guixue Wang^1,*, Yazhou Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 140-141, 2019, DOI:10.32604/mcb.2019.07300

Abstract Zonula occludens-1 (ZO-1) is a peripheral membrane protein belongs to the family of zona occludens proteins and plays an important role as a scaffold protein which cross-links and anchors tight junction (TJ) strand proteins, within the lipid bilayer, to the actin cytoskeleton^[1-2]. Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy junctions of endothelial cells, the functions of the tight junction were also affected. However, the role of ZO-1 before and after stent implantation has not been fully understood. In this study, the expression of ZO-1 were analyzed by qPCR, western blot and… More >

Junyang Huang¹, Shuang Ge¹, Yang Wang¹, Ruolin Du¹, Yazhou Wang¹, Tieying Yin¹, Guixue Wang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 138-139, 2019, DOI:10.32604/mcb.2019.07305

Abstract Tight junctions are the most apical intercellular junctions of the lateral membrane in endothelial cells, regulating the paracellular material and energy exchange and maintain plasma membrane polarity. Occludin protein is one of the important proteins involved in endothelial tight junctions, and also closely related to the occurrence of atherosclerosis. Therefore, the study of occludin is valuable ^[1]. With the implantation of coronary stents, the integrity of the vascular endothelium is damaged and the local mechanical environment at the stent segment was changed ^[2]. The present study tried to explore the impact of mechanical stimulation after stent implantation on the expression… More >

Shuang Ge¹, Ruolin Du¹, Yuhua Huang¹, Guixue Wang¹, Yazhou Wang¹, Tieying Yin^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 136-137, 2019, DOI:10.32604/mcb.2019.07317

Abstract Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy the integrity of the vascular endothelium and the local mechanical environment at the stent segment was changed, especially the biodegradable stents [1]. In this study, 3D printed biodegradable poly (L-lactic acid) stents were implanted into SD rat abdominal aorta and the endothelialization, intimal hyperplasia, and MGF after stent implantation were studied. Besides, based on the MGF we explored the effects of mechanical stimulation on MGF express in vascular endothelial cells and smooth muscle cells, and also the effects of MGF with different concentrations on… More >

Guangyu Zhu¹, Wei Cai^2,*, Qi Yuan¹, Lianglong Chen²

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 59-60, 2019, DOI:10.32604/mcb.2019.05733

Abstract This article has no abstract. More >