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  • Open Access


    Fang-Xia-Dihuang decoction inhibits breast cancer progression induced by psychological stress via down-regulation of PI3K/AKT and JAK2/STAT3 pathways: An in vivo and a network pharmacology assessment


    BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

    Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

  • Open Access


    Effect of Blasting Stress Wave on Dynamic Crack Propagation

    Huizhen Liu1,2, Duanying Wan3, Meng Wang3, Zheming Zhu3, Liyun Yang2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 349-368, 2024, DOI:10.32604/cmes.2023.028197

    Abstract Stress waves affect the stress field at the crack tip and dominate the dynamic crack propagation. Therefore, evaluating the influence of blasting stress waves on the crack propagation behavior and the mechanical characteristics of crack propagation is of great significance for engineering blasting. In this study, ANSYS/LS-DYNA was used for blasting numerical simulation, in which the propagation characteristics of blasting stress waves and stress field distribution at the crack tip were closely observed. Moreover, ABAQUS was applied for simulating the crack propagation path and calculating dynamic stress intensity factors (DSIFs). The universal function was calculated by the fractal method. The… More >

  • Open Access


    Fluid-Structure Coupled Analysis of the Transient Thermal Stress in an Exhaust Manifold

    Liang Yi1,*, Wen Gang1, Nenggui Pan2, Wangui Wang1, Shengshuai Mo1

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.11, pp. 2777-2790, 2023, DOI:10.32604/fdmp.2023.021907

    Abstract The development of thermal stress in the exhaust manifold of a gasoline engine is considered. The problem is addresses in the frame of a combined approach where fluid and structure are coupled using the GT-POWER and STAR-CCM+ software. First, the external characteristic curve of the engine is compared with a one-dimensional simulation model, then the parameters of the model are modified until the curve matches the available experimental values. GT-POWER is then used to transfer the inlet boundary data under transient conditions to STAR-CCM+ in real-time. The temperature profiles of the inner and outer walls of the exhaust manifold are… More >

  • Open Access


    Appraisal of Improvement in Physiological and Metabolic Processes by Exogenously Applied Natural and Synthetic Ascorbic Acid in Okra (Abelmoschus esculentus L.) Fruit Subjected to Water Deficit Stress

    Muhammad Younis1, Nudrat Aisha Akram1,*, Arafat Abdel Hamed Abdel Latef2,*, Muhammad Ashraf3

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2761-2784, 2023, DOI:10.32604/phyton.2023.028801

    Abstract To counteract the effects of drought stress, scientists have adopted several approaches including the use of different chemicals both inorganic and organic, which is contemplated as a highly efficient and cost-effective shot-gun approach. Ascorbic acid (AsA) is a potential organic substance, which widely occurs in plants, and is considered to be an effective antioxidant to counteract reactive oxygen species (ROS). Thus, a pot experiment was performed to assess the relative mitigating impacts of synthetic AsA and naturally occurring AsA in the form of lemon juice (LJ) and orange juice (OJ) on two cultivars of okra (Abelmoschus esculentus L.) namely Sabz… More >

  • Open Access


    An Automatic Classification Grading of Spinach Seedlings Water Stress Based on N-MobileNetXt

    Yanlei Xu, Xue Cong, Yuting Zhai, Zhiyuan Gao, Helong Yu*

    Intelligent Automation & Soft Computing, Vol.37, No.3, pp. 3019-3037, 2023, DOI:10.32604/iasc.2023.040330

    Abstract To solve inefficient water stress classification of spinach seedlings under complex background, this study proposed an automatic classification method for the water stress level of spinach seedlings based on the N-MobileNetXt (NCAM+MobileNetXt) network. Firstly, this study reconstructed the Sandglass Block to effectively increase the model accuracy; secondly, this study introduced the group convolution module and a two-dimensional adaptive average pool, which can significantly compress the model parameters and enhance the model robustness separately; finally, this study innovatively proposed the Normalization-based Channel Attention Module (NCAM) to enhance the image features obviously. The experimental results showed that the classification accuracy of N-MobileNetXt… More >

  • Open Access


    A Novel Topology Optimization Method for Local Relative Displacement Difference Minimization

    Jinyu Gu1, Jinping Qu1, Yingjun Wang1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09161

    Abstract In the topology optimization problem of mechanical structures, the optimization objectives are mainly focused on the compliance minimization, displacement minimization, stress minimization, and so on. However, in practical engineering, these kinds of optimization objectives do not meet all the requirements. Some structures, such as wind turbine blades and engine blades of aircrafts, are required to maintain a superior aerodynamic shape under external loads. This puts a higher requirement on the local deformation homogenization of the structure. Therefore, we proposed a topology optimization method for the minimization of local relative displacement differences considering stress constraints. First, we present a specific topology… More >

  • Open Access


    Study on Variation Law of In-Situ Stress Around Well Under Different Fracturing Technology of Shale Gas Platform Well

    Xiaojun Zhang1, Jun Li1,2,*, Wei Lian2, Gonghui Liu1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.010343

    Abstract In recent years, shale gas development in Fengnan 4 well area of Xinjiang Oilfield is dominated by platform wells. In contrast to conventional fracturing development, the zipper fracturing is primarily used in this block. In this paper, the finite element model of platform well fracturing is established by establishing the mathematical model of multi-cluster fractures interacting with each other, considering the condition of multi-well and multi-fracture. The sequential fracturing of platform wells and the zipper fracturing (well alternating fracturing, fracturing stage alternating fracturing) are simulated in this paper, and the variation law of induced stress and horizontal principal s are… More >

  • Open Access


    Peridynamic Investigation of Surface Stability in Stress-Assisted Corrosion

    Shuaiqi Fan1,*, Chenwen Tian2, Yunpeng Liu2, Ziguang Chen2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09286

    Abstract The peridynamic stress-assisted corrosion model is used to study the stability of the corrosion front of metallic materials under tensile mechanical load. The results show that the solution diffusion trends to smooth the corrosion front, while stress corrosion roughens the corrosion front and leads to higher stress concentrations. Compared to the initial concave profile, the initial convex profile helps to reduce the stressassisted corrosion rate and reduces the role of stress in stress-assisted corrosion. The critical stress of stress-assisted corrosion is introduced in the research, below which the roughness of the corrosion front gradually decreases, meaning that the corrosion front… More >

  • Open Access


    Segment Crack Formation and Density Regulation in Air Plasma Sprayed Coatings

    Liuyu Yang1, Peng Jiang1, Tiejun Wang1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010538

    Abstract Air Plasma Sprayed (APS) Thermal Barrier Coatings (TBCs) have been widely used in land-based gas engines for enhancing the high temperature performance due to their outstanding thermal insulation and high durability. Introducing the segment cracks into APS-TBCs to enhance its durability has been quite attractive approaches nowadays. Qualitative conclusions have been drawn to explore the mechanisms on segment crack formation in the past decades. This article acts as a quantitative study of segment crack formation and crack density regulation mechanism in APS Yttria-Stabilized Zirconia (YSZ) TBCs with experimental observations and analytical calculations. An in-situ stress measurement method is developed through… More >

  • Open Access


    Experimental Investigation on Pure-Shear Ratcheting Behavior of Double-Network Tough Hydrogels

    Xuelian Zhang1, Junjie Liu1,*, Jian Li2, Zhihong Liang1, Han Jiang1, Guozheng Kang1, Qianhua Kan1,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.010142

    Abstract The last decades have witnessed the real and huge potential applications of hydrogels in various areas, including biomedicine, soft robotics, and flexible electronics. The fatigue of hydrogels challenges their reliability and longevity in service, but the related works are not sufficient. In this work, stress-controlled cyclic fatigue tests of a double-network tough hydrogel, consisting of polyacrylamide and alginate polymer networks, under pure shear deformation are investigated. The effects of peak stress, loading rate, peak stress holding time, and environmental relative humidity on the fatigue of the double-network tough hydrogel are considered. The results show that with the increase in peak… More >

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