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  • Open Access

    ABSTRACT

    Numerical Simulation of the Granulation Tissue Resection Operation in Human Trachea

    Zhiguo Zhang1,*, Chen Jiang2

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 83-84, 2019, DOI:10.32604/mcb.2019.05749

    Abstract To quantitatively analyze the aerodynamic changes in patient's trachea after the resection operation of hyperplastic granulation tissue, computational fluid dynamic (CFD) method was utilized to perform the simulation. Firstly, three dimensional finite element model of the patient’s trachea before and after surgery were reconstructed based on CT images; secondly, the numerical simulation based on CFD method was performed to investigate the changes in aerodynamic changes in patient's trachea after excision. Results indicated that the dyspnea symptom was largely alleviated after the removal surgery, the abnormal morphology was obviously improved and the resistance of trachea was More >

  • Open Access

    ABSTRACT

    Using 3D Thin-Layer Model with in Vivo Patient-Specific Vessel Material Properties to Assesse Carotid Atherosclerotic Plaque Vulnerability

    Qingyu Wang1, Dalin Tang1,2,*, Gador Canton3, Zheyang Wu2, Thomas S. Hatsukami4, Kristen L Billiar5, Chun Yuan6

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 81-82, 2019, DOI:10.32604/mcb.2019.05748

    Abstract This article has no abstract. More >

  • Open Access

    ABSTRACT

    Automatic Segmentation Methods Based on Machine Learning for Intracoronary Optical Coherence Tomography Image

    Caining Zhang1, Xiaoya Guo2, Dalin Tang1,3,*, David Molony4, Chun Yang3, Habib Samady4, Jie Zheng5, Gary S. Mintz6, Akiko Maehara6, Mitsuaki Matsumura6, Don P. Giddens4,7

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 79-80, 2019, DOI:10.32604/mcb.2019.05747

    Abstract Cardiovascular diseases are closely associated with sudden rupture of atherosclerotic plaques. Previous image modalities such as magnetic resonance imaging (MRI) and intravascular ultrasound (IVUS) were unable to identify vulnerable plaques due to their limited resolution. Optical coherence tomography (OCT) is an advanced intravascular imaging technique developed in recent years which has high resolution approximately 10 microns and could provide more accurate morphology of coronary plaque. In particular, it is now possible to identify plaques with fibrous cap thickness <65 μm, an accepted threshold value for vulnerable plaques. However, the current segmentation of OCT images are… More >

  • Open Access

    ABSTRACT

    Biomechanical Implications of Bicuspid Pulmonary Valve Dynamic Deformation in Patients with Repaired Tetralogy of Fallot

    Caili Li1, Jing Yao2, Chun Yang3, Di Xu2, Liang Wang4, Dalin Tang4,5,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 77-78, 2019, DOI:10.32604/mcb.2019.05745

    Abstract Pulmonary valve stenosis (PVS) is one common post-operative problem in patients with tetralogy of Fallot (TOF) after repair. Congenital bicuspid pulmonary valve (BPV) is a condition of valvular stenosis, and the occurrence of congenital BPV is often associated with TOF. Compared with the biomechanical simulation model of the bicuspid aortic valve, the BPV is often neglected. In this study, we developed a dynamic biomechanical model of a simulated normal pulmonary root (PR) with tri-leaflet and a model of simulated PR with BPV in patients with repaired TOF in order to describe the effect of geometric… More >

  • Open Access

    ABSTRACT

    Predicting Plaque Progression Using Patient-Specific Fluid-Structure-Interaction Models Based on IVUS and OCT Images with Follow-Up

    Xiaoya Guo1, Dalin Tang1,2,*, David Molony3, Chun Yang2, Habib Samady3, Jie Zheng4, Gary S. Mintz5, Akiko Maehara5, Jian Zhu6, Genshan Ma6, Mitsuaki Matsumura5, Don P. Giddens3,7

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 75-76, 2019, DOI:10.32604/mcb.2019.05743

    Abstract Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. Plaque morphological information on intravascular ultrasound (IVUS) and optical coherence tomography (OCT) images could complement each other and provide for more accurate plaque morphology. Fluid-structure interaction (FSI) models combining IVUS and OCT were constructed to obtain accurate plaque stress/strain and flow shear stress data for analysis. Accuracy and completeness of imaging and advanced modeling lead to accurate plaque progression predictions.
    In vivo IVUS and OCT coronary plaque data at baseline and follow-up were acquired from left circumflex coronary and right coronary… More >

  • Open Access

    ABSTRACT

    Ventricle Stress/Strain Comparison Between Models Using Different Zero-Load Diastole and Systole Morphologies and Models Using Only One Zero-Load Morphologies

    Han Yu1, Pedro J. del Nido2, Tal Geva3, Chun Yang4, Zheyang Wu4, Rahul H. Rathod3, Xueying Huang5, Kristen L. Billiar6, Dalin Tang1,4,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 73-74, 2019, DOI:10.32604/mcb.2019.05837

    Abstract Ventricle mechanical stress and strain calculations play an important role in cardiovascular investigations. Patients with repaired tetralogy of Fallot (TOF) account for the majority of cases with late onset right ventricular (RV) failure. The current surgical approach, including pulmonary valve replacement(PVR), has yielded mixed results with some patients recover RV function after pulmonary valve insertion with or without concomitant RV remodeling surgery but some do not[Therrien, Siu and McLaughlin (2000);]. Cardiac magnetic resonance (CMR) data were collected from 6 healthy volunteers and 12 Tetralogy of Fallot (TOF) patients before PVR with consent obtained. 12 patients… More >

  • Open Access

    ABSTRACT

    Comparison of Aortic Flow Patterns in Patients with and without Aortic Valve Disease: Hemodynamic Simulation Based on PC-MRI and CTA Data

    Lijian Xu1,2, Lekang Yin3, Fuyou Liang1,2,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 71-72, 2019, DOI:10.32604/mcb.2019.05741

    Abstract Recent studies have revealed that aortic valve diseases are associated with the increased incidence of the aortopathy development. However, the influence of aortic valve diseases on aortic hemodynamics remains unclear. The purpose of this study was therefore to investigate the hemodynamic differences in patients with and without aortic valve disease through patient-specific simulations performed on two aorta models (BAV with severe stenosis vs. normal tricuspid aortic valve (TAV)). Realistic geometries and boundary conditions were obtained from computed tomography angiography (CTA) and phase-contrast magnetic resonance imaging (PC-MRI) measurements, respectively. In addition, 4D-MRI were performed to validate More >

  • Open Access

    ABSTRACT

    Papillary Muscle Related Biomechanical Properties of Mitral Valve Chordae Tendineae

    Shengda Chen1,2, Candra Ratna Sari1, Patrick Segers2, Guixue Wang1, Xingshuang Ma1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 69-70, 2019, DOI:10.32604/mcb.2019.05740

    Abstract This article has no abstract. More >

  • Open Access

    ABSTRACT

    Vascular Deformation Analysis Based on in Vivo Intravascular Optical Coherence Tomography Imaging

    Ju Huang1, Cuiru Sun1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 67-68, 2019, DOI:10.32604/mcb.2019.05738

    Abstract Intravascular optical coherence tomography (OCT) has the characteristics of high resolution and fast imaging speed. Continuous images of the same section of the same vessel can reflect the deformation characteristics of the vessel wall under different blood pressure. Digital image processing may be used to segment various structures on the vascular wall and extract the deformation incorporating with biomechanical analysis. Image filtering plays a very important role in image processing. Median filter was used to filter salt and pepper noise in OCT images. Fuzzy function gray processing method was used to suppress irrelevant information and More >

  • Open Access

    ABSTRACT

    Finite Element Analysis of Fatigue Behavior of Stent in Tapered Arteries

    Xiang Shen1,*, Hongfei Zhu1, Song Ji1, Jiabao Jiang1, Yongquan Deng1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 65-65, 2019, DOI:10.32604/mcb.2019.05737

    Abstract In order to open up the blocked lumen and remodel the blood environment, vascular stents were usually used to transplant into narrowed blood vessels. Due to its minimally invasive and highly efficiency, stenting has achieved great success in the treatment of cardiovascular diseases. However, failure of stents due to its fatigue will damage the arterial wall, leading to adverse reactions such as thrombosis and in-stent restenosis (ISR), which severely limited its long-term outcome. Therefore, it was very important to predict the service life of stents, especially in tapered arteries.
    FEA was adopted to study the… More >

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