Congenital Heart Disease

About the Journal

Congenital Heart Disease: Clinical Studies from Fetus to Adulthood is an Open Access Peer-review journal. It is the only clinical journal focused exclusively on the study and treatment of congenital defects in children and adults.

Indexing and Abstracting

Science Citation Index Expanded (Clarivate Analytics): 2019 Impact Factor: 1.663; Scopus CiteScore (Impact per Publication 2019): 2.7; SNIP (Source Normalized Impact per Paper 2019): 0.943;Journal Citation Report/Science Edition (JCR); MEDLINE/PubMed (NLM); Embase (Elsevier); EBSCO Publishing; ProQuest, etc.

Previously published by Wiley (, Congenital Heart Disease starts to be published by Tech Science Press from 2020. It supports Open Access Policy and an Article Processing Charge (APC) of $1200 US dollars applies to all accepted papers (submitted after 1st August 2020).

  • D-Transposition of the Great Arteries after Arterial Switch Operation: Usefulness of 3D-Echocardiography for Left Ventricle Function Evaluation
  • Abstract Objective: The objective of this study was to assess left ventricle (LV) function and remodeling by three-dimensional echocardiography (3DE) in patients who underwent arterial switch procedure (ASO) for transposition of great arteries (TGA) in long-term follow-up. Methods and Results: We studied 54 asymptomatic patients (39 male) who have undergone single-stage ASO for TGA, aged 13.7 ± 4.7 years, with a normal LV ejection fraction (EF), compared to healthy peers. We evaluated LV volume and function in asymptomatic patients with normal ejection fraction by 3DE. All patients had normal EF, measured by modified Simpson’s method (mean 60.9 ± 3.5%) and by… More
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  • Pulmonary Hemodynamics and Outcome in a Large Cohort of Patients with Sinus Venosus Septal Defect
  • Abstract Background: Left-to-right shunt in sinus venosus septal defect (SVSD) may affect resistive (pulmonary vascular resistance–PVR) and elastic (pulmonary artery compliance-PAC) pulmonary artery properties. This study aimed at evaluating (1) impact of age, (2) pulmonary hemodynamics, and (3) outcome in a large cohort of SVSD patients. Methods: This study included 136 patients with SVSD (median age at diagnosis 14 (IQR 5–48) years, 47% male) of which 87 underwent catheterization. Pressures were measured and cardiac output was evaluated using the Fick principle at diagnosis. PVR, PAC and their product (RC time) were calculated. Results: Surgical repair was performed in 128 (94%) at… More
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  • Safety and Efficacy of Transcatheter Closure of Atrial Septal Defects in Everyday Practice. A Multicenter Study in a Developing Country
  • Abstract Background: Transcatheter closure of secudum atrial septal defect (ASD) has gained wide acceptance since its introduction more than 3 decades ago. Safety and efficacy of the procedure in everyday practice needs continuous update. Objective: The aim of the study is to determine the incidence of complications and identify everyday management protocols. Methods: This is a prospective nonrandomized study including all the patients with Secundum ASD or fenestrated IAS referred to two different congenital heart diseases centers in Ain Shams university and sohag university in Egypt over 2 years with an indication for closure according to American and European guidelines. A… More
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  • Assessing Univentricular Function in Adult Fontan Using 3D Echocardiography
  • Abstract Objective: To determine the accuracy of assessing univentricular function in adult Fontan patients using three-dimensional (3D) volumetric echocardiography. Design: A prospective observational study in an adult Fontan patient cohort. Setting: University Hospitals Birmingham, NHS Foundation Trust. Patients: 26 patients were enrolled in the study all aged over 18 years, possessing the Fontan anatomy, with no contraindications to Cardiac Magnetic Resonance (CMR) imaging and in sinus rhythm. Intervention: All patients underwent transthoracic echocardiography using a Philips EPIQ 7 and X5-1 transducer. End diastolic volume (EDV), end systolic volume (ESV), stroke volume (SV) and ejection fraction (EF) were obtained using two dimensional… More
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  • Chronotropic Response and Pulmonary Function are Associated with Exercise Performance in Children and Adolescents with Repaired Tetralogy of Fallot Independent of Cardiac Function
  • Abstract Objective: The determinants of exercise capacity in repaired tetralogy of Fallot (rTOF) are multifactorial and remain incompletely understood. This study sought to evaluate the association of chronotropic response with exercise parameters and investigate the determinants of heart rate reserve (HRR) in a cohort of children and adolescents with rTOF. Design: We retrospectively analyzed patients with rTOF, age 8–18 years, who underwent cardiac magnetic resonance (CMR) and cardiopulmonary exercise test (CPET) for research purposes. Linear regression models were performed to test associations among clinical, CMR and CPET parameters. Outcomes included percent-predicted maximum VO2 (%mVO2) and HRR. Results: A total of 148… More
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  • Use of Implantable Cardioverter-Defibrillators in Congenital Heart Disease and Pediatric Patients: Results from the German National Registry for Congenital Heart Defects
  • Abstract Background: Sudden cardiac death is a leading cause of death in patients with congenital heart disease (CHD). Risk stratification for implantable cardioverter defibrillators (ICD) remains difficult due to limited data about use and outcome of device therapy in CHD patients in larger community-based cohorts. Methods and results: Out of a dataset with more than 50,000 patients registered at the German National Register for Congenital Heart Defects, 109 patients (median age 35.5; IQR 23.75–46.00), 68 (62%) male) with an ICD were identified and were retrospectively analyzed. Although the number of implantations increased steadily throughout the investigated time interval from 2001 to… More
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