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ARTICLE
Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors
Chuanwei Xu1, Renju Ding2, Chuanping Xu3,*
1 Department of Breast and Thyroid Surgery, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
2 The First Department of Lung Disease, Linyi Hospital of Traditional Chinese Medicine, Linyi, China
3 Linyi Tumor Hospital, Linyi, China
* Corresponding Author: Chuanping Xu. Email:
Oncologie 2020, 22(1), 43-51. https://doi.org/10.32604/oncologie.2020.012445
Abstract
To analyze the effects of different surgical procedures for the treatment
of thyroid cancer on the expression levels of serum interleukin-17 (IL-17), IL-35,
soluble interleukin-2 receptor (SIL-2R), and the prognostic factors. Seventy-eight
patients with differentiated thyroid cancer were selected and grouped as control
group (CG) (n = 39, underwent subtotal thyroidectomy) and observation group
(OG) (n = 39, underwent total thyroidectomy). The serum IL-17, IL-35, and SIL-
2R expression levels; the incidence of complications; and the differentiated
thyroid carcinoma (DTC) relapse rate were compared between the two groups. The
serum IL-17 and SIL-2R levels were lower in the OG than in the CG on the third,
fifth, and seventh days after the operation, but the IL-35 levels were higher than
those in the CG (
p < 0.05). There were no cases of relapse in the OG, and the DTC
relapse rate was lower than that of the CG (15.38%) (
p < 0.05). The differences in
age; lesion diameter; serum IL-17, IL-35, and SIL-2R expression levels; AJCC
thyroid cancer stage; and disease type between DTC relapse and relapse-free
patients were statistically significant (
p < 0.05). Older age; higher IL-17, lower IL-
35, and higher SIL-2R expression levels; higher AJCC thyroid cancer stage; and
disease type were positively correlated with DTC relapse (
p < 0.05). Compared
with subtotal thyroidectomy, total thyroidectomy for the treatment of thyroid
cancer has greater advantages in improving immune inflammation and reducing
the relapse rate. Older age; higher IL-17, lower IL-35, and higher SIL-2R
expression levels; higher AJCC thyroid cancer stage; and disease type are
independent risk factors affecting thyroid cancer relapse after surgery. These
findings can reference the selection of clinical surgery procedures in the treatment
of thyroid cancer.
Keywords
Cite This Article
Xu, C., Ding, R., Xu, C. (2020). Analysis of the Effects of Different Surgical Procedures for the Treatment of Thyroid Cancer on the Expression Levels of IL-17, IL-35, and SIL-2R and the Prognostic Factors.
Oncologie, 22(1), 43–51. https://doi.org/10.32604/oncologie.2020.012445
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