Open Access

ARTICLE

Apoptosis in the prostate

J. M. Fitzpatrick, R. W. G. Watson

1 Professor and Chairman, Department of Surgery, University College Dublin, Dublin, Ireland
2 Director of Surgical Research Laboratory, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
Address correspondence to Professor John Fitzpatrick, Consultant Urologist & Professor of Surgery, University College Dublin, 47 Eccles Street, Dublin 7, Ireland

Canadian Journal of Urology 2003, 10(2), 1796-1798.

Abstract

The prostate requires androgens for development and glandular maintenance, dying by the process of apoptosis following their removal. Anti-androgen therapy is targeted to induce this process but eventually fails with the emergence of an androgen independent cancer. These cells have development mechanisms to survive with out androgen impart due to the expression of anti-apoptotic factors.

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