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Apoptosis in the prostate
1 Professor and Chairman, Department of Surgery, University College Dublin, Dublin, Ireland
2 Director of Surgical Research Laboratory, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
Address correspondence to Professor John Fitzpatrick,
Consultant Urologist & Professor of Surgery, University
College Dublin, 47 Eccles Street, Dublin 7, Ireland
Canadian Journal of Urology 2003, 10(2), 1796-1798.
Abstract
The prostate requires androgens for development and glandular maintenance, dying by the process of apoptosis following their removal. Anti-androgen therapy is targeted to induce this process but eventually fails with the emergence of an androgen independent cancer. These cells have development mechanisms to survive with out androgen impart due to the expression of anti-apoptotic factors.Keywords
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Copyright © 2003 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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