Open Access

CASE REPORT

Transitional cell carcinoma of the bladder producing Parathyroid hormone-related protein (PTHrP)

Uzair B. Chaudhary¹, David L. Milling¹, Nabil K. Bissada²

1 Department of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA
2 Department of Urology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Address correspondence to Dr. Nabil K. Bissada, Department of Urology, University of Arkansas for Medical Sciences, 800 Marshall Street, Little Rock, Arkansas 72202 USA

Canadian Journal of Urology 2004, 11(1), 2136-2138.

Abstract

Hypercalcemia associated with transitional cell carcinoma (TCC) is rarely encountered. We report a case of TCC of bladder with documented production of parathyroid hormone related protein (PTHrP). Our patient had a rapidly progressive course and died 2 months after radical cystectomy. Literature suggests that these patients present with advanced stage and carry a poor prognosis. The histopathologic features, treatment and prognosis associated with this rare paraneoplastic syndrome are reviewed.

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Keywords

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