Comparison of histologic grade between initial and follow-up biopsy in untreated, low to intermediate grade, localized prostate cancer
R. Choo1, V. Do1, L. Sugar2, L. Klotz2, E. Bahk1, E. Hong1, C. Danjoux1, G. Morton1, G. DeBoer1
Canadian Journal of Urology, Vol.11, No.1, pp. 2118-2124, 2004
Abstract Objective: To examine the change of histologic grade of untreated, low to intermediate grade, clinically localized prostate cancer over time on repeat prostate biopsy.
Methods and materials: In a prospective single-arm cohort study, patients were managed with observation alone unless they met pre-defined criteria of disease progression (PSA, clinical or histologic progression). Sixty-seven (54%) of a total of 123 eligible patients underwent follow-up prostate biopsy. Median time to the follow-up biopsy was 22 months (range: 7-60).
Results: On the follow-up biopsy, Gleason score was unchanged in 20 patients (30%), upgraded in 19 (28%), and downgraded in 27 (40%).… More >