Association of rise in C-reactive protein with decline in renal function following partial nephrectomy
Seth A. Cohen1, Ryan P. Kopp1, Kerrin L. Palazzi1,
Michael A. Liss1, Reza Mehrazin2, Jason Woo1,
Hak J. Lee1, Ramzi Jabaji1, Kyle Gillis1,
Song Wang1, Robert W. Wake2, Anthony L. Patterson2,
Ithaar H. Derweesh1
Canadian Journal of Urology, Vol.22, No.6, pp. 8085-8092, 2015
Abstract Introduction: To investigate association of C-reactive protein (CRP), a marker of systemic inflammation, with renal functional decline in patients undergoing partial nephrectomy (PN) for renal mass.
Materials and methods: Retrospective study of patients who underwent PN between February 2006-March 2011, with ≥6 months follow up. Data was analyzed between two groups: CRP increase ≥0.5 mg/L from 6 months postoperative ("CRP rise," CRPR), versus no CRP increase ≥0.5 ("CRP stable," CRPS). Primary outcome was change in estimated glomerular filtration rate (ΔeGFR, mL/min/1.73 m²), with de novo postoperative stage III chronic kidney disease (stage III-CKD, eGFR <60 mL/min/1.73 m²)… More >