Home / Journals / CJU / Vol.22, No.2, 2015
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  • Open AccessOpen Access

    EDITORIAL

    The testosterone storm

    Leonard G. Gomella
    Canadian Journal of Urology, Vol.22, No.2, pp. 7677-7677, 2015
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    LEGENDS IN UROLOGY

    LEGENDS IN UROLOGY

    Frans M. J. Debruyne
    Canadian Journal of Urology, Vol.22, No.2, pp. 7678-7680, 2015
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    REVIEW

    Botulinum neurotoxin A for overactive bladder treatment: advantages and pitfalls

    Că​lin Chibelean, Ioan Alin Nechifor-Boilă​
    Canadian Journal of Urology, Vol.22, No.2, pp. 7681-7689, 2015
    Abstract Introduction: Overactive bladder (OAB) syndrome is a special condition characterized by urgency, with or without urinary urge incontinence (UUI), associated to frequency and nocturia, with important consequences on patients' quality of life (QoL). Administered as intradetrusor injections, botulinum neurotoxin type A (BoNT/A) is a new, promising, minimally invasive treatment option for OAB patients, non-compliant to conventional antimuscarinics. The aim of our study was to perform a systematic review of the literature concerning the efficiency and safety of different BoNT/A products in the treatment of OAB.
    Materials and methods: A thorough PubMed search was performed. After having… More >

  • Open AccessOpen Access

    ARTICLE

    Prognostic significance of cystoscopy findings following neoadjuvant chemotherapy for muscle-invasive bladder cancer

    Ahmed M. Mansour1, Mark S. Soloway2, Ahmed Eldefrawy3, Rakesh Singal4, Shivam Joshi5, Murugesan Manoharan5
    Canadian Journal of Urology, Vol.22, No.2, pp. 7690-7697, 2015
    Abstract Introduction: To evaluate the potential significance of cystoscopy findings following neoadjuvant chemotherapy (NAC) as prognostic indicator in patients undergoing radical cystectomy for muscle-invasive bladder cancer (MIBC).
    Materials and methods: Patients who received NAC prior to radical cystectomy for MIBC were analyzed. Patients were divided into two groups according to cystoscopy performed after two cycles of NAC: responders and non-responders. Univariate analysis was performed to analyze associations between observed response to chemotherapy and pT stage, pN stage and tumor downstaging. Logistic regression modeling was fitted to evaluate predictors for extravesical disease and pathologic downstaging. Kaplan-Meier analysis was… More >

  • Open AccessOpen Access

    ARTICLE

    Impact of post prostate biopsy hemorrhage on multiparametric magnetic resonance imaging

    Ali-Reza Sharif-Afshar1, Tom Feng1, Steven Koopman1, Christopher Nguyen2, Quanlin Li3, Eugene Shkolyar1, Rola Saouaf2, Hyung L. Kim1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7698-7702, 2015
    Abstract Introduction: Hemorrhage induced by prostate biopsy can interfere with the interpretation of prostate magnetic resonance imaging (MRI).
    Materials and methods: We reviewed 101 patients who had prostate multiparametric MRI (MP-MRI) and radical prostatectomy.
    Results: On MRI obtained within 4 weeks following the biopsy, hemorrhage was seen in 26/36 (72.2%) patients. Patients having a MRI between 4-6 weeks of the biopsy had hemorrhage in 8/14 (57.1%) cases. After 6 weeks, hemorrhage was less common but still present in 24/46 (52%) patients. There were five patients who had prostate MRI prior to biopsy and served as a control… More >

  • Open AccessOpen Access

    ARTICLE

    Influence of statin use on clinicopathological characteristics of localized prostate cancer and outcomes obtained after radical prostatectomy: a single center study

    Susanna Cattarino1, Thomas Seisen1,2, Sarah J. Drouin1, Raphaële Renard-Penna1, Priscilla Leon1,2, Eva Comperat3, Pierre Mozer1, Olivier Cussenot1,2, Morgan Rouprêt1,2
    Canadian Journal of Urology, Vol.22, No.2, pp. 7703-7708, 2015
    Abstract Introduction: To assess the impact of statin use on biochemical recurrence (BCR) of prostate cancer after radical prostatectomy (RP).
    Materials and methods: Data from all men treated with robot-assisted laparoscopic RP (RALRP) for localized prostate cancer between 2009 and 2014 at our institution were prospectively collected: age, body mass index (BMI), statin-use status, preoperative prostate-specific antigen (PSA) level, clinical T stage, biopsy Gleason score (bGS), D'Amico risk group, pathological T stage, specimen Gleason score (sGS), multifocality, perineural invasion, positive surgical margins and time to BCR. Univariate and multivariate analysis were performed to test associations between statin… More >

  • Open AccessOpen Access

    ARTICLE

    Weighted Gleason scores do not outperform standard clinical Gleason scores

    Antonio Cusano1, Peter Haddock1, Max Jackson1, Ilene Staff2, Joseph R. Wagner1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7709-7714, 2015
    Abstract Introduction: Predicting patient survival rates following radical prostatectomy remains an area of clinical interest. We compared the ability of standard clinical Gleason scores and alternative 'weighted' Gleason scores to predict pathology, margin status and recurrence in prostate cancer.
    Materials and methods: Patients who underwent robotic radical prostatectomy performed by a single surgeon between Jan 2007 - Dec 2008 were included. Tumor at the inked margin in pathologic samples was considered a positive margin. Recurrence was defined as PSA ≥ 0.2 or the institution of salvage therapy. Standard pathologic Gleason scores were recorded. The proportion of tumor… More >

  • Open AccessOpen Access

    ARTICLE

    Knowledge of erectile dysfunction and pelvic floor disorders among young adults: a cross-sectional study

    Lee A. Richter1, Robert E. Gutman1, Eshetu Tefera2, Allison Estep1, Cheryl B. Iglesia1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7715-7719, 2015
    Abstract Introduction: The prevalence of pelvic floor disorders (PFD) in aging women is comparable to the prevalence of erectile dysfunction (ED) in aging men. The objective of this study was to assess young adults' familiarity with the definition, prevalence, etiology, and treatment of PFD and ED.
    Materials and methods: Women and men aged 18-40 years completed a validated survey (Prolapse and Incontinence Knowledge Quiz) to assess knowledge of urinary incontinence (UI) and pelvic organ prolapse (POP). Both groups completed a similar questionnaire created to assess knowledge of ED. Participants were asked to estimate the prevalence of these… More >

  • Open AccessOpen Access

    ARTICLE

    Staged urethroplasty: comparison of early functional results and quality of life in mesh graft and buccal mucosa technique

    Daniel Pfalzgraf1,2, Luis Kluth1, Philip Reiss1, Margit Fisch1, Roland Dahlem1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7720-7726, 2015
    Abstract Introduction: To assess bothersome results of surgery and changes in quality of life (QoL) in patients with two-staged urethral reconstruction. In patients requiring two-staged urethroplasty a functional corpus spongiosum is usually absent, and complications such as urinary dribbling, ejaculation problems and penile deviation can be expected. Data on these complications, patient satisfaction and QoL is limited.
    Materials and methods: Retrospective analysis by chart review and a standardized questionnaire of 19 consecutive patients with urethral strictures treated by two-staged urethroplasty with buccal-mucosa-graft or mesh-graft.
    Results: Overall success rate was 84%. Mean follow up 11.2 months, mean length… More >

  • Open AccessOpen Access

    ARTICLE

    Ureteroscopy for nephrolithiasis in transplanted kidneys

    Ryan Swearingen, William W. Roberts, J. Stuart Wolf Jr.
    Canadian Journal of Urology, Vol.22, No.2, pp. 7727-7731, 2015
    Abstract Introduction: While percutaneous nephrolithotomy (PCNL) is often the procedure of choice for renal and ureteral calculi in transplant kidneys, retrograde ureteroscopy (URS) is a less frequently applied but excellent option if stone burden is small. We retrospectively examined nine surgical cases performed in seven patients in what appears to be the largest single institutional series reported to date.
    Materials and methods: Seven patients underwent nine retrograde URS between June of 2009 and September of 2013, by two endourologists. These cases were reviewed retrospectively.
    Results: Among the nine procedures, we were able to address the stone(s) endoscopically… More >

  • Open AccessOpen Access

    ARTICLE

    Acute renal colic during pregnancy: management and predictive factors

    Marie N’gamba1,*, Souhil Lebdai1,*, Camille Hasting2, Paul Panayotopoulos1, Myriam Ammi1, Loïc Sentilhes2, Philippe Descamps2, Abdel-Rahmène Azzouzi1, Pierre Bigot1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7732-7738, 2015
    Abstract Introduction: The aim of this study was to identify predictive factors of urolithiasis etiology for acute renal colic (ARC) during pregnancy.
    Materials and methods: We performed a retrospective review of all pregnant women hospitalized for an ARC between January 2007 and October 2012 in the department of Obstetrics and Gynecology of a University Hospital. Univariate and multivariate regression models were used to assess potential predictive factors of urolithiasis etiology.
    Results: We included 82 patients. A urolithiasis was identified in 24 (29.3%) patients. In univariate analysis, we identified the following predictive factors for a urolithiasis etiology: primiparity… More >

  • Open AccessOpen Access

    ARTICLE

    Heparin and alkalinized lidocaine versus alkalinized lidocaine for treatment of interstitial cystitis symptoms

    C. Lowell Parsons1, James A. Koziol2, Jeffrey G. Proctor3, Paul Zupkas1, Sulabha Argade1
    Canadian Journal of Urology, Vol.22, No.2, pp. 7739-7744, 2015
    Abstract Introduction: Interstitial cystitis (IC), sometimes referred to as IC/bladder pain syndrome, is a substantial health care problem. Once considered a rare, orphan disease, it is now believed to be relatively common. This pilot study was undertaken to determine if the combination of heparin and alkalinized lidocaine (heparin-lidocaine) was more efficacious than alkalinized lidocaine at relieving pain and urgency symptoms associated with IC and also capable of yielding higher lidocaine absorption.
    Materials and methods: A single blind study was conducted on 14 IC patients with a heparin-lidocaine combination versus alkalinized lidocaine instilled intravesically. In a separate study… More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Gross hematuria caused by nutcracker syndrome and segmental pseudoaneursym

    Timothy H. Atkinson, Matthew Love, Jamie Messer
    Canadian Journal of Urology, Vol.22, No.2, pp. 7745-7747, 2015
    Abstract Nutcracker syndrome is a rare disorder characterized by extrinsic compression of left renal vein by the superior mesenteric artery and aorta. Prevalence of the disease is unknown, but presents most commonly with gross hematuria and fank pain. Diagnosis requires a high index of suspicion and treatment consists of a wide range of vascular surgical options with a more recent focus using an endovascular approach. We present a case of a 29-year-old female with continuous gross hematuria and fank pain from a segmental artery pseudoaneursym secondary to nutcracker and pelvic congestion syndrome. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Totally intracorporeal robot-assisted laparoscopic reverse seven ileal ureteric reconstruction

    Nikita Abhyankar1, Christopher Vendryes1, Leslie A. Deane2
    Canadian Journal of Urology, Vol.22, No.2, pp. 7748-7751, 2015
    Abstract We describe the first reported case of completely intracorporeal robot-assisted laparoscopic reverse seven ileal ureteric reconstruction. The patient was a woman with bilateral, long segment ureteric strictures secondary to pelvic surgery and radiation. This report demonstrates that robotic reconstruction is a viable option even in a complex patient with a hostile abdomen. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Large cell differentiation of metastatic prostate cancer after androgen deprivation therapy

    Rutveej Patel1, Izak Faiena1, Jules Geltzeiler2
    Canadian Journal of Urology, Vol.22, No.2, pp. 7752-7754, 2015
    Abstract We present a case of a 75-year-old male with a history of high risk prostate cancer who underwent androgen deprivation therapy and palliative radiation treatments for his disease. Subsequently, he presented with gross hematuria and severe lower urinary tract symptoms. A palliative transurethral resection of the prostate (TURP) at that time, demonstrated large cell differentiated neuroendocrine carcinoma with metastasis to the lung. We review the limited literature on this rare form of disease and present current treatment strategies. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis

    Scott M. Norberg1, Michelle Oros1, Varsha Manucha2, Daniel Eun1, Marijo Bilusic3
    Canadian Journal of Urology, Vol.22, No.2, pp. 7755-7757, 2015
    Abstract Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed More >

  • Open AccessOpen Access

    HOW I DO IT

    The prone ureteroscopic technique for managing large stone burdens

    Kevan M. Sternberg1, Bruce L. Jacobs2, Benjamin J. King1, Jared B. Wachterman1, Khaled Shahrour2, Katherine M. Theisen2, Sarah E. Sprauer2, Erin Ohmann2, Timothy D. Averch2
    Canadian Journal of Urology, Vol.22, No.2, pp. 7758-7762, 2015
    Abstract Percutaneous nephrolithotomy (PCNL) is the standard treatment for patients with large stone burdens, but can be associated with significant complications. Flexible ureteroscopy is an alternative approach that is less invasive, but often requires multiple procedures. Typically, many factors play a role in the decision to perform PCNL or ureteroscopy. The challenge is that it is difficult to predict which stone burdens will be able to be cleared ureteroscopically. We describe our approach using initial prone ureteroscopy with the transition to standard prone PCNL if required. More >

  • Open AccessOpen Access

    HOW I DO IT

    Adjunctive use of Narrow Band Imaging during transurethral resection/vaporization of bladder tumors to aid In identifying mucosal and sub-mucosal hypervascularity

    Gregory J. Diorio1, Daniel J. Canter2,3
    Canadian Journal of Urology, Vol.22, No.2, pp. 7763-7766, 2015
    Abstract For patients with non-muscle invasive bladder cancer, cystoscopy and transurethral resection/vaporization of the bladder tumor plays an integral role in the treatment of a given patient’s bladder cancer. Although considered the current gold standard for tumor detection, traditional or white light cystoscopy has been shown to have its limitations visualizing both small papillary tumors and/or carcinoma in-situ. Current efforts have been directed to closing this gap with data demonstrating that by identifying these previously missed lesions, tumor recurrence and progression rates are reduced, thereby improving patient outcomes.
    Narrow Band Imaging, which can be used during… More >

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