The role of vitamin D, estrogen, calcium sensing receptor genotypes and serum calcium in the pathogenesis of prostate cancer
Attila Szendroi1, Gabor Speer2, Adam Tabak2,3, Janos P. Kosa2, Peter Nyírády1, Attila Majoros1, Imre Romics1, Peter Lakatos2
Canadian Journal of Urology, Vol.18, No.3, pp. 5710-5716, 2011
Abstract Introduction: Prostate cancer is the second leading cause of cancer death among men in developed countries. Estrogen receptor-alpha (ER-α), vitamin D receptor (VDR), and the calcium-sensing receptor (CaSR), partly through their effects on calcium levels are implicated in the proliferation and carcinogenesis in the prostate gland. VDR, ER-α and CaSR genes show polymorphisms in humans that appear to have clinical significance in many pathological conditions, such as prostate cancer. Our aim was to evaluate the role of ER-α (PvuII, XbaI), VDR (BsmI) and CaSR (A986S) gene polymorphisms and serum calcium levels in the pathogenesis of prostate… More >