Image acquisition and interpretation of 18F-DCFPyL (piflufolastat F 18) PET/CT: How we do it
Steven P. Rowe1,2,3, Andrew F. Voter1,4, Rudolf A. Werner1,5, Katherine A. Zukotynski6,7,8, Martin G. Pomper1,2,3, Michael A. Gorin9, Lilja B. Solnes1,3
Canadian Journal of Urology, Vol.30, No.1, pp. 11432-11437, 2023
Abstract Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) is rapidly becoming widely accepted as the standard-of-care for imaging of men with prostate cancer. Labeled indications for regulatoryapproved agents include primary staging and recurrent disease in men at risk of metastases. The first commercial PSMA PET agent to become available was 18F-DCFPyL (piflufolastat F 18), a radiofluorinated small molecule with high-affinity for PSMA. The regulatory approval of 18F-DCFPyL hinged upon two key, multi-center, registration trials, OSPREY (patient population: highrisk primary staging) and CONDOR (patient population: biochemical recurrence). In this manuscript, we will (1) review key findings More >