Open Access

BOOK REVIEW

Jian-Guo Wen
Canadian Journal of Urology, Vol.32, No.5, pp. 367-368, 2025, DOI:10.32604/cju.2025.073520 - 30 October 2025
Abstract This article has no abstract. More >

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EDITORIAL

Kevin R. Loughlin^*
Canadian Journal of Urology, Vol.32, No.5, pp. 369-370, 2025, DOI:10.32604/cju.2025.074435 - 30 October 2025
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341

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94

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LEGENDS IN UROLOGY

Eric A. Klein
Canadian Journal of Urology, Vol.32, No.5, pp. 371-373, 2025, DOI:10.32604/cju.2025.073515 - 30 October 2025
Abstract This article has no abstract. More >

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119

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REVIEW

Andrea Panunzio¹, Rossella Orlando¹, Federico Greco^2,3, Giovanni Mazzucato⁴, Floriana Luigina Rizzo¹, Serena Domenica D’Elia¹, Antonio Benito Porcaro⁵, Alessandro Antonelli⁵, Alessandro Tafuri^1,6,*
Canadian Journal of Urology, Vol.32, No.5, pp. 375-384, 2025, DOI:10.32604/cju.2025.066140 - 30 October 2025
Abstract Background: The Barthel Index (BI) measures the level of patient independence in activities of daily living. This review aims to summarize current evidence on the use of the BI in urology, highlighting its potential as a tool for assessing patients prior to surgery. Materials and methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted for studies evaluating the BI in patients undergoing urologic surgery, following Systematic Review and Meta-analyses (PRISMA) guidelines. The BI was investigated both as a descriptor of baseline or postoperative health status and a prognostic indicator. A qualitative… More >

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153

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REVIEW

Zheng Liu^1,#, Xuhong Yan^2,#, Guicheng Liu¹, Jingyi Zhang¹, Xujun Yu³, Degui Chang^1,*, Liang Dong^3,*
Canadian Journal of Urology, Vol.32, No.5, pp. 385-400, 2025, DOI:10.32604/cju.2025.068136 - 30 October 2025
Abstract Late-onset hypogonadism (LOH), characterized by the intersection of aging and androgen deficiency, impacts the health of approximately 2%−39% of middle-aged and elderly men, underscoring the need for comprehensive research. Animal models, serving as analogs of human diseases, are indispensable for investigating disease mechanisms and facilitating drug development. However, the diverse array of animal models utilized for LOH research has led to a lack of standardized modeling approaches and evaluation systems, potentially impeding progress in understanding the pathogenesis and therapeutic development. In this paper, we summarize and compile the characteristics, methods, and evaluation systems of rodent More >

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138

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ARTICLE

Abdulbari Bener^1,2,*, Ünsal Veli Üstündağ³, Emir Barışık⁴, Cem Cahit Barışık⁵
Canadian Journal of Urology, Vol.32, No.5, pp. 401-409, 2025, DOI:10.32604/cju.2025.067184 - 30 October 2025
（This article belongs to the Special Issue: Prostate Cancer: Biomarkers, Diagnosis and Treatment)
Abstract Objectives: The evidence remains insufficient and controversial for evaluating modifiable parameters—such as vitamin D, calcium, ferritin, and uric acid—as preclinical biomarkers to contribute to the prevention and early diagnosis of prostate cancer, a disease with a prevalence of up to 10%–20% in men over 50 and strongly associated with environmental factors including diet (high in fat and red meat), obesity, physical inactivity, and carcinogen exposure. This study aims to investigate the potential biomarker role of vitamin D, calcium, ferritin, and uric acids in reducing the risk of prostate cancer (PCa). Methods: The case-control design was… More >

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130

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ARTICLE

Jingcheng Lyu^1,2,#, Ruiyu Yue^1,2,#, Yichen Zhu^1,2, Ye Tian^1,2,*, Xinyi Hu^1,2,*
Canadian Journal of Urology, Vol.32, No.5, pp. 411-422, 2025, DOI:10.32604/cju.2025.066758 - 30 October 2025
Abstract Objective: Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. Method: A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using t-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary More >

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178

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ARTICLE

Azik Hoffman^1,2,*, Eyal Kochavi³, Gilad E. Amiel^1,2
Canadian Journal of Urology, Vol.32, No.5, pp. 423-432, 2025, DOI:10.32604/cju.2025.064740 - 30 October 2025
Abstract Objectives: Initial treatment for Non-Muscle Invasive Bladder Cancer (NMIBC) has remained mostly unchanged in recent decades. Cryotherapy with CO₂ has been commonly used in medicine for many years. In this study, we present the results of a pre-clinical study aimed at developing a novel cryoablation device to treat superficial low-grade bladder lesions. Methods: Following initial technical and developmental studies, a rigid cryotherapy device was developed. A technical and efficacy assessment was conducted utilizing the porcine model. Overall, twenty-six ablation areas (up to four per animal) were evaluated. Following an initial routine cystoscopy, the bladder irrigation medium… More >

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594

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208

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ARTICLE

Federico Greco^1,2,*, Marco Cataldo³, Valerio D’Andrea^2,4, Luca Pugliese⁵, Andrea Panunzio⁶, Alessandro Tafuri⁶, Bruno Beomonte Zobel^2,4, Carlo Augusto Mallio^2,4
Canadian Journal of Urology, Vol.32, No.5, pp. 433-443, 2025, DOI:10.32604/cju.2025.068390 - 30 October 2025
（This article belongs to the Special Issue: AI, Radiomics, and Radiogenomics in Urologic Oncology: Toward a New Era of Precision Imaging)
Abstract Background: Radiogenomics offers a non-invasive approach to correlate imaging features with tumor molecular profiles. This study aims to identify computed tomography (CT) imaging characteristics associated with positive NIPA-like domain containing 4 (NIPAL4) expression in clear cell renal cell carcinoma (ccRCC) and to develop a radiogenomic predictive model to support personalized risk stratification. Methods: A retrospective analysis was conducted on 241 ccRCC patients from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA) databases. Clinical, pathological, and CT features were compared between NIPAL4-positive and NIPAL4-negative groups. A penalized logistic regression model was built to… More >

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997

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234

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ARTICLE

Jingcheng Lyu^1,2,#, Ruiyu Yue^1,2,#, Boyu Yang^1,2, Xuanhao Li^1,2, Jian Song^1,2,*
Canadian Journal of Urology, Vol.32, No.5, pp. 445-456, 2025, DOI:10.32604/cju.2025.068853 - 30 October 2025
（This article belongs to the Special Issue: Advancing Early Detection of Prostate Cancer: Innovations, Challenges, and Future Directions)
Abstract Objectives: This study aimed to develop an artificial intelligence (AI)-based image recognition system using the nnU-Net adaptive neural network to assist clinicians in detecting magnetic resonance imaging (MRI)-invisible prostate cancer. The motivation stems from the diagnostic challenges, especially when MRI findings are inconclusive (Prostate Imaging Reporting and Data System [PI-RADS] score ≤ 3). Methods: We retrospectively included 150 patients who underwent systematic prostate biopsy at Beijing Friendship Hospital between January 2013 and January 2023. All were pathologically confirmed to have clinically significant prostate cancer, despite negative findings on preoperative MRI. A total of 1475 MRI… More >

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834

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177

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ARTICLE

Lihao Zhang^1,2, Lin Cao^1,2, Lige Huang^1,2, Jie Wang^1,2, Jiabing Li^2,3,*
Canadian Journal of Urology, Vol.32, No.5, pp. 457-468, 2025, DOI:10.32604/cju.2025.067364 - 30 October 2025
（This article belongs to the Special Issue: Personalized Medicine in Urology: The Role of Inflammatory Bio-Markers in Urothelial Carcinoma)
Abstract Background: Studies have indicated an association between inflammatory factors (IFs) in the blood and the development of bladder cancer (BC). This study aimed to explore the correlation and clinical significance of IFs with the pathological grading of BC. Methods: A retrospective analysis was conducted on the preoperative blood routine results, postoperative pathological findings, and baseline information of 163 patients. Patients were divided into high-grade and low-grade groups based on pathological grading. Group comparisons and logistic regression analyses were performed using R software version 4.1.3 to explore the relationships between IFs and BC pathological grading. Results: The… More >

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641

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128

Open Access

HOW I DO IT

Joon Yau Leong^1,*, Vignesh Prasad², Carlos J. Perez Kerkvliet¹, Andrew A. Wagner³, Richard E. Link⁴, Mihir S. Shah¹
Canadian Journal of Urology, Vol.32, No.5, pp. 469-475, 2025, DOI:10.32604/cju.2025.066348 - 30 October 2025
Abstract In recent years, the introduction of the Da Vinci Single Port (SP) robotic platform has opened new doors for the treatment of localized renal masses. This technology, particularly when utilized via a regionalized retroperitoneal (RP) approach, offers several distinct advantages that may improve patient recovery. These advantages include easier access to both anterior and posterior renal tumors, avoidance of the peritoneal cavity with complicating adhesions, and simplified supine positioning, potentially reducing the risk of musculoskeletal or nerve injuries. Yet, the learning curve for RP surgery remains steep due to the unfamiliarity of many surgeons with More >

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632

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160

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HOW I DO IT

Eriz Özden^1,*, Erdem Öztürk²
Canadian Journal of Urology, Vol.32, No.5, pp. 477-482, 2025, DOI:10.32604/cju.2025.067507 - 30 October 2025
（This article belongs to the Special Issue: Advancing Early Detection of Prostate Cancer: Innovations, Challenges, and Future Directions)
Abstract Overview: Freehand transperineal prostate biopsy (TPPB) needle guides are designed to maintain a parallel alignment between the co-axial introducer needle and the ultrasound (US) transducer. However, this parallel alignment necessitates transducer angulations within the patient’s rectum for sampling anterior or posterior regions of the prostate, which introduces several problems both for the patient and the operator. This article introduces a technique using a TPPB needle guide system with a novel angle-adjustment feature, which minimizes intrarectal transducer movements. Objectives: Freehand TPPB typically requires anterior or posterior angulation of the ultrasound (US) transducer, which leads to prostate More >

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223

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COMMUNICATION

Ahmed Ahmed¹, Bilal Farhan², Amr Alam-Eldin¹, Maged Amin Helmy¹, Mohammed Mostafa Hussein¹, Zakieldahshoury Mohamed¹, Hassaan A. Gad¹, Suraj Nayan Vodnala^3,*
Canadian Journal of Urology, Vol.32, No.5, pp. 483-490, 2025, DOI:10.32604/cju.2025.067228 - 30 October 2025
（This article belongs to the Special Issue: Urolithiasis in Focus: Integrated Perspectives on Infection, Metabolic Dysfunction, and Contemporary Management)
Abstract Background: As occurrence rates of pediatric ureteral stones have increased, evaluation of optimal treatment modalities has become imperative. This study’s primary goal is to compare outcomes between dusting and fragmentation techniques using Holmium:YAG (Ho:YAG) laser lithotripsy in children with ureteral stones. Methods: A prospective randomized study was conducted at Aswan University Hospitals from June 2023 to December 2024. One hundred children, under the age of 18, with single, mid- or distal, ureteral stones (5–20 mm) were randomized into two groups. Group A received laser dusting (0.2–0.6 J, 20–40 Hz), while Group B received fragmentation (0.8–1.5… More >

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584

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132

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ARTICLE

Phillip Taboada¹, Rohit R. Badia¹, Dhillon Advano¹, Andrew Murphy¹, Christina Sze¹, Ryan J. Mauck¹, Jennifer Tse¹, Jeffrey Gahan², Claus G. Roehrborn¹, Ramy Goueli^1,*
Canadian Journal of Urology, Vol.32, No.5, pp. 491-499, 2025, DOI:10.32604/cju.2025.068150 - 30 October 2025
Abstract Background: Aquablation is a robotic-assisted, water jet-based transurethral therapy for benign prostatic hyperplasia (BPH). Concerns about postoperative hematuria led to the practice of limited transurethral resection (TUR) with cauterization. This study aimed to assess the impact of tranexamic acid (TXA) on hematuria outcomes when combined with limited TUR after Aquablation. Methods: We retrospectively analyzed men undergoing Aquablation at our institution (October 2020–July 2024). Demographic, prostate, surgical, and hematuria outcomes were extracted from electronic medical records. Kruskal-Wallis test compared medians. Results: Of 131 patients, 113 (86%) had limited TUR; 31 (27%) received 1 g TXA perioperatively. TXA… More >

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960

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159

Open Access

CASE REPORT

Dimindra Karki^*, Ghizlane Yaakoubi, Beth Edelblute, Ahmed Aboumohamed^*
Canadian Journal of Urology, Vol.32, No.5, pp. 501-507, 2025, DOI:10.32604/cju.2025.063294 - 30 October 2025
Abstract Background: Epithelioid angiomyolipoma (EAML) is an uncommon renal tumor variant with histologic and radiologic features that can mimic renal cell carcinoma (RCC) on imaging due to the paucity of fat compared to the classic AML. EAML may exhibit aggressive behavior, including local invasion, recurrence, and distant metastases to the liver, lungs, and lymph nodes. Although recent reports suggest that up to one-third of EAML cases may behave malignantly, variability in diagnostic criteria and limited case series contribute to uncertainty regarding its true clinical course. Case Description: This case report describes a 19-year-old female presenting with an… More >

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190

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CASE REPORT

Sarbjit Mohapatra^1,*, Nandkumar Madhekar², Sameer Ratkal³, Jaideep Ratkal¹
Canadian Journal of Urology, Vol.32, No.5, pp. 509-513, 2025, DOI:10.32604/cju.2025.063783 - 30 October 2025
Abstract Background: Isolated renal aspergilloma is a rare medical entity posing difficult diagnostic and treatment challenges. Case Description: We document a case of Primary Renal Aspergilloma in a 55-year-old male with diabetes mellitus, hypertension, and chronic liver disease. The individual presented with features of obstructive uropathy due to fungal balls requiring retrograde endoscopic intervention and drainage. The cheesy material retrieved during the procedure was identified as an Aspergilloma on histopathology. Due to far and fewer reports in the medical literature, there have been no standard diagnostic & management strategies, which in turn has resulted in unacceptably high More >

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713

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166

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CASE REPORT

Raidizon Mercedes, Eric Eidelman, Michael Mawhorter, Max Yudovich, Alireza Aminsharifi^*
Canadian Journal of Urology, Vol.32, No.5, pp. 515-520, 2025, DOI:10.32604/cju.2025.067973 - 30 October 2025
Abstract Background: Spontaneous rupture of the urinary bladder (SRUB) is a rare condition characterized by bladder rupture without any trauma or previous instrumentation. Diagnosing SRUB can be challenging, leading to potential delays in treatment and significant morbidity. Case description: We present a case of a 75-year-old male with a complex medical history, including atrial fibrillation, systemic lupus erythematosus, antiphospholipid syndrome, and chronic anticoagulation, who developed sudden onset gross hematuria and abdominal pain following bilateral internal iliac artery angioembolization for a spontaneous pelvic hematoma in the setting of supratherapeutic anticoagulation. Extraperitoneal bladder perforation was confirmed by CT cystogram.… More >

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617

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131

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ARTICLE

Ellen M. Cahill, Ankur U. Choksi, Sharath S. Reddy, Dylan C. H. Heckscher, Katherine Rotker, Stanton C. Honig^*
Canadian Journal of Urology, Vol.32, No.5, pp. 521-527, 2025, DOI:10.32604/cju.2025.064559 - 30 October 2025
Abstract Introduction: Spermatocelectomy is a surgical procedure performed for symptomatic spermatoceles. Published data is limited with respect to recurrence rates, complication rates, and patient satisfaction. The core concept of spermatocelectomy is to identify the communication between epididymis and spermatocele, which can be difficult and may result in spermatocele recurrence. We postulate that a combined spermatocelectomy with epididymectomy will yield a lower rate of recurrence. Methods: A retrospective chart review of patients with symptomatic spermatoceles undergoing spermatocelectomy with or without epididymectomy at our institution was performed. Patients were excluded from epididymectomy if they were interested in fertility… More >

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361

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107

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ARTICLE

Ozgu Aydogdu^1,*, Onur Erdemoglu², Halil Ibrahim Bozkurt², Tansu Degirmenci², Michael Winder³
Canadian Journal of Urology, Vol.32, No.5, pp. 529-538, 2025, DOI:10.32604/cju.2025.064564 - 30 October 2025
Abstract Objectives: Treatment of patients with lower urinary tract symptoms (LUTS) is often challenging. In men, the origin of LUTS, in particular overactive bladder (OAB) symptoms, is often due to prostate enlargement. However, patients with chronic prostate inflammation (CPI) also frequently experience OAB. Thus far, it is not known if the inflammation per se or concomitant prostate enlargement is the underlying cause of LUTS. Currently, we aim to examine if there is any correlation between CPI and the persistence of OAB symptoms in patients with benign prostate hyperplasia (BPH). Methods: Fifty-one men underwent transurethral resection of… More >

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