Alpha-dystroglycan staining pattern and mortality in patients undergoing radical prostatectomy with lymph node positive prostate cancer
Ahmad N. Alzubaidi1, Kenneth G. Nepple1, Annah Vollstedt1, Laila Dahmoush3, Deqin Ma3, Michael D. Henry1,2,3,4, James A. Brown1,4
Canadian Journal of Urology, Vol.26, No.6, pp. 10054-10060, 2019
Abstract Introduction: Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins involved in tissue mechanical stability and matrix organization. Initial work has demonstrated that alpha-DG expression is decreased in many types of adenocarcinoma, including prostate, and potentially associated with the development of metastatic disease. However, the consistency between prostate and lymph node alpha-DG staining has not been previously reported. Additionally, identification of an immunohistochemical marker associated with prostate cancer grade, stage, need for adjuvant or salvage therapy, and mortality would have potential clinical value.
Materials and methods: Node-positive, margin-negative radical prostatectomy specimens from a single institution… More >