Open Access

BOOK REVIEW

Paul H. Chung
Canadian Journal of Urology, Vol.26, No.6, pp. 10006-10006, 2019
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EDITORIAL

Kevin R. Loughlin
Canadian Journal of Urology, Vol.26, No.6, pp. 10007-10007, 2019
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LEGENDS IN UROLOGY

Philip Hanno
Canadian Journal of Urology, Vol.26, No.6, pp. 10008-10011, 2019
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REVIEW

Jacob J. Adashek¹, Alex Leonard^2,*, Samantha W. Nealon³, Arvind Krishnan³, Gerard C. Mosiello⁴, Jasreman Dhillon⁵, Philippe E. Spiess³
Canadian Journal of Urology, Vol.26, No.6, pp. 10012-10021, 2019
Abstract Introduction: Extramammary Paget’s disease (EMPD) is a rare and complex condition, for which no established guidelines exist regarding diagnosis and management. There have been recent improvements in the diagnosis and management of EMPD, largely due to an enhanced understanding of its underlying pathogenesis.
Materials and methods: A literature search on PubMed including articles that describe pathogenesis, clinical diagnosis, treatment modalities, and future treatment were selected and included to build this review.
Results: Recent studies suggest the expression of HER2 and androgen receptors, which could be useful targets for future treatment strategies. Carcinoembryonic antigen as a biomarker for EMPD More >

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ARTICLE

Preeya K. Mistry¹, Bradley A. Morganstern², Haris Ahmed¹, Lane S. Palmer²
Canadian Journal of Urology, Vol.26, No.6, pp. 10022-10025, 2019
Abstract Introduction: The American Academy of Pediatrics views Certified Child Life Specialists (CCLS) as “an important component of pediatric hospital-based care to address the psychosocial concerns that accompany hospitalization.” CCLSs help patients and parents navigate the complex medical system in order to minimize psychosocial and emotional stress by implementing age-appropriate coping skills. This survey explores the perceptions towards CCLS and their utilization in pediatric urology.
Materials and methods: A SurveyMonkey questionnaire was developed and distributed to Society for Pediatric Urology members (SPU) (n = 314). Providers were queried about CCLS implementation and their perception regarding CCLS’s role in… More >

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ARTICLE

Zenon Pogorelic^1,2, Christopher Neumann², Miro Jukic¹
Canadian Journal of Urology, Vol.26, No.6, pp. 10026-10032, 2019
Abstract Introduction: The aim of this study was to investigate demographic and clinical characteristics and outcomes of the treatments of the patients with an unusual presentation of testicular torsion (TT) and to clarify their peculiarities.
Material and methods: From January 1999 until December 2017, the case records of 149 patients who underwent surgery for TT were retrospectively reviewed. Out of that number, 25 patients were identified with unusual presentation of an acute scrotum (14 patients who presented with abdominal pain only, and 11 who presented with testicular torsion in the inguinal canal).
Results: The median age of all children… More >

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ARTICLE

Alexis Wang¹, Charles F. Polotti², Shu Wang¹, Sammy Elsamra^2,*, Mohummad Minhaj Siddiqui^1,*
Canadian Journal of Urology, Vol.26, No.6, pp. 10033-10038, 2019
Abstract Introduction: Robotic cystectomy with intracorporeal urinary diversion (RCID) is a technically challenging procedure. It is understood that this approach has a learning curve; however, limited studies have characterized this learning curve. The cumulative sum (CUSUM) method plots the learning curve. The aim of this study was to use the CUSUM approach to investigate the number of cases required to reach a consistent, desired performance level for RCID.
Materials and methods: A retrospective study of the first 27 and 28 RCID cases performed by two new fellowship-trained faculty at two separate institutions from November 2014 to January 2018… More >

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ARTICLE

Emilie Dardenne¹, Quentin Manach¹, Pietro Grande^1,2, Riccardo Campi^1,3, Florie Gomez¹, Benjamin Granger⁴, Vincent Misrai⁵, Marc-Olivier Bitker¹, Pierre Mozer¹, Morgan Roupret¹
Canadian Journal of Urology, Vol.26, No.6, pp. 10039-10044, 2019
Abstract Introduction: To investigate the mid-term results of penile prosthesis (PP) implantation in patients with erectile dysfunction (ED) from a “real-life” historic cohort in a French academic center.
Materials and methods: All patients receiving an inflatable PP between 2004 and 2014 in our institution were included in this study. ED was assessed preoperatively using the IIEF-5 questionnaire. Postoperative satisfaction with the PP was assessed using the EDITS questionnaire at each follow-up visit. Postoperative complications were classed according to the Clavien classification. Surgical and functional outcomes were recorded prospectively.
Results: Seventy-six men received a PP during the 10-year study period.… More >

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ARTICLE

Jordan Hill¹, Mike Paulden², Christopher McCabe², Scott A. North³, Peter Venner³, Nawaid Usmani¹
Canadian Journal of Urology, Vol.26, No.6, pp. 10045-10053, 2019
Abstract Introduction: Enzalutamide (Enza) is an effective treatmentformetastaticcastrate-resistantprostatecancer (mCPRC). However, Enza is not cost-effective (CE) at willingness to pay (WTP) thresholds from $0-$125 000/quality adjusted life years (QALYs) and is therefore a strain on valuable health care dollars. Metformin (Met) isinexpensive(~$8.00/month)andisthoughttoimprove prostate cancer specifc and overall survival compared to thosenottakingMet.Wehypothesizedthattheremustbe an added effect Met could provide that would make Enza CEtherebyalleviatingthisfnancialstrainongovernment health care budgets.
Materials and methods: We constructed a Markov model and performed a threshold analysis to narrow in on the added effect needed to make such a combination therapy cost-effective at various WTP thresholds.
Results:… More >

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ARTICLE

Ahmad N. Alzubaidi¹, Kenneth G. Nepple¹, Annah Vollstedt¹, Laila Dahmoush³, Deqin Ma³, Michael D. Henry^1,2,3,4, James A. Brown^1,4
Canadian Journal of Urology, Vol.26, No.6, pp. 10054-10060, 2019
Abstract Introduction: Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins involved in tissue mechanical stability and matrix organization. Initial work has demonstrated that alpha-DG expression is decreased in many types of adenocarcinoma, including prostate, and potentially associated with the development of metastatic disease. However, the consistency between prostate and lymph node alpha-DG staining has not been previously reported. Additionally, identification of an immunohistochemical marker associated with prostate cancer grade, stage, need for adjuvant or salvage therapy, and mortality would have potential clinical value.
Materials and methods: Node-positive, margin-negative radical prostatectomy specimens from a single institution… More >

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RESIDENT’S CORNER

Daniel L. Pelzman, Michelle J. Semins
Canadian Journal of Urology, Vol.26, No.6, pp. 10061-10063, 2019
Abstract Renal pseudoaneurysm following ureteroscopy is a rare cause of hematuria usually diagnosed and treated with angiography and embolization. Here we present a case of a small pseudoaneurysm causing intermittent flank pain and gross hematuria associated with clot retention initially diagnosed during ureteroscopy and subsequently treated with a combined endourologic and endovascular approach. More >

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RESIDENT’S CORNER

Bryant J. Van Leeuwen, Melissa M. Bavitz, Shawna Boyle
Canadian Journal of Urology, Vol.26, No.6, pp. 10064-10066, 2019
Abstract Extragonadal germ cell tumors are germ cell tumors with no evidence of a primary tumor within the gonads, most often located in the mediastinum or retroperitoneum. We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland. More >

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