Home / Journals / CJU / Vol.18, No.6, 2011
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  • Open AccessOpen Access

    EDITORIAL

    Celebrating the Death of PSA Screening?

    Leonard G. Gomella
    Canadian Journal of Urology, Vol.18, No.6, pp. 5987-5987, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    LEGENDS IN UROLOGY

    LEGENDS IN UROLOGY

    Donald G. Skinner
    Canadian Journal of Urology, Vol.18, No.6, pp. 5988-5990, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    REVIEW

    Pazopanib: an orally administered multi-targeted tyrosine kinase inhibitor for locally advanced or metastatic renal cell carcinoma

    Gokhan Koc1, Xu Wang2, Yi Luo3
    Canadian Journal of Urology, Vol.18, No.6, pp. 5991-5997, 2011
    Abstract Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 90% of all kidney cancers. Prior to 2005, treatment options for patients with locally advanced and metastatic disease were limited. After the approval of sorafenib by the US Food and Drug Administration (FDA), other tyrosine kinase inhibitors (TKI) have been successively used for treating patients with advanced RCC. Pazopanib is the newest, orally bioavailable, and multi-targeted TKI, and is considered a first-line treatment option for certain patients. This review summarizes updated clinical studies, mechanism of action, and pharmacokinetics… More >

  • Open AccessOpen Access

    REVIEW

    Information that affects patients’ treatment choices for early stage prostate cancer: a review

    Deb Feldman-Stewart1,2, Michael D. Brundage1,2,3, Christine Tong1
    Canadian Journal of Urology, Vol.18, No.6, pp. 5998-6006, 2011
    Abstract Introduction: We conducted a systematic review of primary evidence to clarify what information influences treatment selection by patients with early stage prostate cancer.
    Materials and methods: We conducted a systematic review of the Web of Knowledge, using the ALL DATABASES option. Papers were then triaged out on the basis of the title and/or abstract, leaving 120 papers. Reviewing the full papers resulted in a final corpus of 21 papers.
    Results: The data suggest that patients typically balance potential benefits against potential side effects but in a complex way with large variation across patients. For some patients, potential benefits… More >

  • Open AccessOpen Access

    ARTICLE

    Surgical management of BPH in patients on oral anticoagulation: transurethral bipolar plasma vaporization in saline versus transurethral monopolar resection of the prostate

    Nicolas B. Delongchamps1, Grégoire Robert2, Alexandre de la Taille3, Olivier Haillot4, Charles Ballereau5, Christian Saussine6, François Kleinclauss7, Abdel-Rahmène Azzouzi8, Bertrand Lukacs9, Olivier Dumonceau10, Marc Fourmarier11, Marian Devonec12, Aurélien Descazeaud13
    Canadian Journal of Urology, Vol.18, No.6, pp. 6007-6012, 2011
    Abstract Introduction: To compare postoperative outcomes of patients on oral anticoagulation (OA) treated with transurethral plasma vaporization of the prostate in saline water (TUVis) and transurethral resection of the prostate (TURP).
    Materials and methods: Between January and December 2009, 111 patients on OA therapy were treated with either TURP or TUVis in eight centers. Types of OA and perioperative management were collected. Postoperative outcomes were statistically compared between the two groups.
    Results: A total of 57 (51%) and 54 (49%) patients were treated with TURP and TUVis, respectively. Types of OA were not significantly different between the two groups,… More >

  • Open AccessOpen Access

    ARTICLE

    AdVance male sling in irradiated patients with stress urinary incontinence

    Jack M. Zuckerman, Britton Tisdale, Kurt McCammon
    Canadian Journal of Urology, Vol.18, No.6, pp. 6013-6017, 2011
    Abstract Introduction: This study aims to evaluate the complication rate and efficacy of the AdVance sling (American Medical Systems, Minnetonka, MN, USA) in patients with stress urinary incontinence (SUI) and a history of pelvic radiation.
    Materials and methods: A retrospective chart review was conducted of all men at our institution with a history of prostate cancer and subsequent radiation therapy who were treated with an AdVance sling for SUI.
    Results: Between 2007 and 2009, the AdVance sling procedure was performed in 27 patients with prior pelvic radiation therapy. The mean patient age was 73.2 years. At an average follow-up… More >

  • Open AccessOpen Access

    ARTICLE

    Critical assessment of prebiopsy parameters for predicting prostate cancer metastasis and mortality

    Pim J. van Leeuwen, Roderick C. N. van den Bergh, Tineke Wolters, Xiaoye Zhu, Meelan Bul, Fritz H. Schröder, Chris H. Bangma, Monique J. Roobol
    Canadian Journal of Urology, Vol.18, No.6, pp. 6018-6024, 2011
    Abstract Introduction: The value of characteristics assessed prior to diagnosis in predicting aggressive prostate cancer, metastases, and mortality in men participating in a screening study were identified.
    Materials and methods: This study included 19,950 men aged 55 to 74 years at first screening in the European Randomized Study of Screening for Prostate Cancer. Factors such as age, Charlson comorbidity index, family history of prostate cancer, vasectomy status, International Prostate Symptom Score (IPSS), digital rectal examination (DRE) status, transrectal ultrasound (TRUS) findings, prostate volume, and prostate-specific antigen (PSA) level were evaluated. Participants were followed for a median of 11.1… More >

  • Open AccessOpen Access

    ARTICLE

    Estimation of clinically significant prostate volumes by digital rectal examination: a comparative prospective study

    Sarfraz Ahmad, Rustom Pervez Manecksha, Ivor Michael Cullen, Robert Joseph Flynn, Thomas Eugene Dermott McDermott, Ronald Grainger, John Alan Thornhill
    Canadian Journal of Urology, Vol.18, No.6, pp. 6025-6030, 2011
    Abstract Introduction: Reliable quantification of prostate volume is important to correctly select patients with benign prostatic hyperplasia (BPH) most likely to benefit from medical therapy [e.g. 5 alpha-reductase inhibitors (5-ARIs)] and in selecting appropriate surgical approach. We aim to determine the reliability of digital rectal examination (DRE) in estimation of prostate volume which may be helpful in patient selection for 5-ARIs therapy.
    Materials and methods: Patients requiring transrectal ultrasound (TRUS) guided prostate biopsy were recruited in this prospective study. DRE was performed twice for each patient. Clinicians categorized prostate volume on DRE into small, medium and large, and… More >

  • Open AccessOpen Access

    ARTICLE

    Evaluation of preoperative bioimpedance spectroscopy quantifcation of body composition on predicting postoperative outcomes following robotic assisted radical prostatectomy (RARP)

    Gina M. Badalato1, Matthew S. Wosnitzer1, Matthew D. Truesdale1, Marco Sandri2, Woo Jin Ko1, Jaime Landman1, Ketan K. Badani1
    Canadian Journal of Urology, Vol.18, No.6, pp. 6031-6036, 2011
    Abstract Introduction: Bioimpedance spectroscopy (BIS) is a novel, precise quantification of body composition (BC) using low electrical currents through tissue. Accurate BC quantification may better predict postoperative outcomes. We compared BIS-BC and body mass index (BMI) for correlation with post-surgical outcomes in robotic assisted radical prostatectomy (RARP) patients.
    Materials and methods: Preoperative BIS-BC and BMI analyses were conducted on men with biopsy-proven prostate cancer undergoing RARP. Height, weight, percentage and fat mass (PFM, FM), percentage and fat-free mass (PFFM, FFM), percentage and total body water (PTBW, TBW), and percentage and intracellular/extracellular water (PICW, PECW, ICW, ECW) were obtained… More >

  • Open AccessOpen Access

    MINIMALLY INVASIVE AND ROBOTIC SURGERY

    Results of high intensity focused ultrasound treatment of prostate cancer: early Canadian experience at a single center

    Dean S. Elterman1,2, Jack Barkin1,3, Sidney B. Radomski1, Neil E. Fleshner1, Brian Liu1, Kira Bensimon1, Samantha Arora1, Michael Robinette1, Antonio Finelli1
    Canadian Journal of Urology, Vol.18, No.6, pp. 6037-6042, 2011
    Abstract Introduction: High-intensity focused ultrasound (HIFU) is a non-invasive technique that uses focused ultrasound waves to ablate tissue. This retrospective study evaluates the early HIFU experience at a single Canadian center.
    Materials and methods: Ninety-five patients were treated between March 2006 and December 2007 using the Sonablate 500 device (Focus Surgery, Indianapolis, IN, USA). Follow-up was conducted at 3-month intervals and included serial prostate-specific antigen (PSA) measurements, assessment of erectile function using the International Index of Erectile Function (IIEF), and evaluation of continence rates using the Expanded Prostate Cancer Index Composite (EPIC) questionnaire. Early and late complications were… More >

  • Open AccessOpen Access

    MINIMALLY INVASIVE AND ROBOTIC SURGERY

    Impact of margin status at 37 months after robot assisted radical prostatectomy

    Jonathan N. Warner1, Rafael N. Nunez1, Chinedu O. Mmeje1, Thomas V. Colby2, Robert G. Ferrigni1, Mitchell R. Humphreys1, Paul E. Andrews1, Erik P. Castle1
    Canadian Journal of Urology, Vol.18, No.6, pp. 6043-6049, 2011
    Abstract Introduction: We evaluate the impact of margin length, location, and pathologic stage on biochemical recurrence (BCR) after robot assisted radical prostatectomy (RARP) at 37 months of follow up.
    Materials and methods: A total of 1420 patients underwent a robot assisted radical prostatectomy between March 2004 and May 2010. Patients who received adjuvant therapy, those who never achieved an undetectable prostate-specific antigen (PSA), and those who had less than 18 months of follow up were excluded. Patients were then divided and evaluated based on margin status.
    Results: In total, 419 patients were included in the analysis. Eighty-three had a… More >

  • Open AccessOpen Access

    HOW I DO IT

    Management of pelvic organ prolapse

    Faisal Ahmed, Tiffany Sotelo
    Canadian Journal of Urology, Vol.18, No.6, pp. 6050-6053, 2011
    Abstract Symptomatic pelvic organ prolapse can afflict up to 10% of women. Urinary incontinence, voiding dysfunction or difficulty possibly related to bladder outlet obstruction are common symptoms. Infrequently hydronephrosis or defecatory dysfunction can be seen. The management of pelvic organ prolapse (POP) should start with adequate assessment of all pelvic floor complaints. If a patient is not symptomatic, surgical intervention is usually not indicated. While the use of a variety of graft materials are available today including porcine, dermal and synthetic grafts, that are used in some surgical approaches to pelvic organ prolapse, other more conservative More >

  • Open AccessOpen Access

    CLINICAL TRIALS

    Open clinical uro-oncology trials in Canada

    Eric Winquist, George Rodrigues
    Canadian Journal of Urology, Vol.18, No.6, pp. 6054-6059, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Renal autotransplantation following long segment iatrogenic ureteric injury

    Ke Jia Teo, Chin Tiong Heng, David Consigliere, Ho Yee Tiong
    Canadian Journal of Urology, Vol.18, No.6, pp. 6060-6063, 2011
    Abstract The authors describe a case of iatrogenic right ureteric injury post duodenectomy and right hemi-colectomy. Renal autotransplantation was chosen as the treatment for the upper ureteric injury. This was successfully performed and the renal function of the transplanted kidney was subsequently preserved. The advantages and disadvantages of this approach are discussed. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    A rare presentation of nephrogenic adenoma: multiple upper tract lesions in a female patient

    Dock Winston1, Jennifer K. Yates2, Ravi Munver1,2, Debra Fromer1,2
    Canadian Journal of Urology, Vol.18, No.6, pp. 6064-6065, 2011
    Abstract Nephrogenic adenomas are rare benign lesions of the urinary tract occurring most frequently in the bladder of male patients. We report the case of a female patient presenting with gross hematuria, which lateralized to the left ureter on cystoscopy. At the time of ureteroscopy, two polypoid lesions were identified in an upper and lower pole calyx, which were found on biopsy to be nephrogenic adenomas. In addition to reporting this case, we review the literature for the pathophysiology of nephrogenic adenomas. More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Hypercreatinemia: think beyond acute kidney injury

    Ankur Gupta1, Mohan Biyani1, Mudit Gupta2, Marc Eric Saltel3
    Canadian Journal of Urology, Vol.18, No.6, pp. 6066-6068, 2011
    Abstract Urinary bladder rupture associated with severe hypercreatinemia is a rare clinical presentation. We herein report a 60-year-old interesting patient who was found to have intraperitoneal bladder rupture and pseudo-renal failure. High rate of suspicion and timely diagnosis is the key in management of this condition, which led to complete recovery in our patient. More >

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