Determinants of renal functional decline after open partial nephrectomy: a comparison of warm, cold, and non-ischemic modalities
Ramzi Jabaji1, Kerrin L. Palazzi1, Reza Mehrazin2,
Seth A. Cohen1, James H. Masterson3, Jason R. Woo1,
Hak Lee1,4, Michael A. Liss1,4, Ryan P. Kopp1, Song Wang1,
Sean P. Stroup3, Anthony L. Patterson2, James O. L’Esperance3, Ithaar H. Derweesh1,4
Canadian Journal of Urology, Vol.21, No.1, pp. 7126-7133, 2014
Abstract Introduction: Renal functional decline after partial nephrectomy (PN) may be related to a variety of non-modifiable and modifiable factors, including ischemia time (IT) and modality. We sought to determine the impact of these factors on renal functional degeneration after PN.
Materials and methods: Multicenter retrospective analysis (n = 347) was performed, identifying patients who underwent open PN using warm, cold, and non-ischemic techniques. Primary outcome was development of de novo chronic kidney disease (CKD), (estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m²), at 1 year follow-up. Univariate and multivariable analysis (MVA) were performed examining factors associated… More >