Open Access

EDITORIAL

Kevin R. Loughlin
Canadian Journal of Urology, Vol.27, No.2, pp. 10142-10143, 2020
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LEGENDS IN UROLOGY

Ralph V. Clayman
Canadian Journal of Urology, Vol.27, No.2, pp. 10144-10146, 2020
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ARTICLE

Mihir Desai¹, Mo Bidair², Naeem Bhojani³, Andrew Trainer⁴, Andrew Arther⁴, Eugene Kramolowsky⁵, Leo Doumanian¹, Dean Elterman⁶, Ronald P. Kaufman, Jr.⁷, James Lingeman⁸, Amy Krambeck⁸, Gregg Eure⁹, Gopal Badlani¹⁰, Mark Plante¹¹, Edward Uchio¹², Greg Gin¹², Larry Goldenberg¹³, Ryan Paterson¹³, Alan So¹³, Mitchell R. Humphreys¹⁴, Claus G. Roehrborn¹⁵, Steven Kaplan¹⁶, Jay Motola¹⁶, Kevin C. Zorn³
Canadian Journal of Urology, Vol.27, No.2, pp. 10147-10153, 2020
Abstract Introduction: To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates.
Materials and methods: Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent an ultrasound-guided robotically executed Aquablation procedure in a prospective multicenter international clinical trial (WATER II). Baseline, procedural and follow-up parameters were recorded at baseline and scheduled postoperative visits. Herein we report 2-year safety and efficacy for this cohort.
Results: Mean prostate volume was 107 cc (range 80-150 cc). Mean IPSS improved from… More >

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ARTICLE

Canadian Journal of Urology, Vol.27, No.2, pp. 10154-10161, 2020
Abstract Introduction: In addition to survival endpoints, we explored the impact of Charlson Comorbidity-Index (CCI) on the acute and late toxicities in men with localized prostate cancer who received dose-escalated definitive radiotherapy (RT).
Materials and methods: CCI scores at diagnosis and survival outcomes were identified for men with intermediate/high-risk prostate cancer treated with RT (1/2007-12/2012). Study-cohort was accordingly grouped into no, mild and severe comorbidity (CCI-0, 1 or 2+). CCI-groups were compared for demographics, prognostic-factors; and RT-related toxicities based on RTOG/CTCAE criteria. Kaplan-Meier curves and Uni/multivariate (MVA) analyses were used to examine the influence of CCI-group on overall… More >

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ARTICLE

Survandita Dhawan¹, Ephrem O. Olweny²
Canadian Journal of Urology, Vol.27, No.2, pp. 10162-10166, 2020
Abstract Introduction: Phyllanthus niruri (P. niruri) is the most commonly listed active ingredient in commercially available herbal therapies for kidney stones, despite limited supporting clinical evidence. We performed a meta-analysis to evaluate its efficacy in reducing stone burden. We used Google Trends to analyze its relative popularity in internet searches relative to conventional stone therapies.
Materials and methods: A comprehensive literature search for controlled human studies containing data on the effect of P. niruri treatment on stone size and number was performed. Pooled analysis of change in mean stone size and number with P. niruri was performed using… More >

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ARTICLE

E. David Crawford¹, Andrew V. Schally²
Canadian Journal of Urology, Vol.27, No.2, pp. 10167-10173, 2020
Abstract Introduction: In this article we advance a potential explanation for the incidence of cardiovascular (CV) and cardiometabolic risk in patients undergoing androgen deprivation therapy (ADT) for prostate cancer. Our conceptual model involves the differential impact of gonadotropin-releasing hormone (GnRH) agonists and antagonists on the follicle-stimulating hormone (FSH) system.
Materials and methods: Authors searched online repositories and meeting abstract databases for relevant materials.
Results: Mounting evidence links FSH with development and progression of prostate cancer. What is also becoming clear is that the differential effects of GnRH agonists and antagonists on FSH may at least partially explain the differing… More >

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ARTICLE

Jonathan Ewald¹, Herbert Hodgson¹, Jerry Thomas¹, Nazih Khater², Mohamed Keheila², Muhannad Alsyouf², Javier L. Arenas², Mohammad Hajiha², D. Duane Baldwin²
Canadian Journal of Urology, Vol.27, No.2, pp. 10174-10180, 2020
Abstract Introduction: To improve the success rate and safety of ureteral stent insertion, we sought to identify the effect of guidewire type and prior use upon the force needed to advance a 6Fr ureteral stent over various guidewires.
Materials and methods: Two hundred forty stent insertion trials were performed in an ex vivo porcine urinary tract model. Ten trials were randomly performed over 12 new and 12 used guidewires. For each trial, the force required to advance a 6Fr Cook double-pigtail ureteral stent was recorded. Guidewires included the Olympus Glidewire, Cook Fixed Core, and Boston Scientific Amplatz Super… More >

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ARTICLE

G. Luke Machen, Johnathan Doolittle, Jay I. Sandlow
Canadian Journal of Urology, Vol.27, No.2, pp. 10181-10184, 2020
Abstract Introduction: Patients with suboptimal semen parameters following vasectomy reversal represent a diagnostic and therapeutic challenge. This may be caused by either partial or complete anastomotic obstruction. Despite the relatively common clinical use of corticosteroids in this patient population, data remain sparse. Thus, we set out to evaluate the safety and efficacy of prednisone after vasectomy reversal.
Materials and methods: A chart review was performed from January 1, 2008 to September 30, 2018 to identify men in which prednisone was used for suspected anastomotic obstruction after vasectomy reversal. Obstruction was based on sub-optimal or decreasing semen parameters and… More >

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HOW I DO IT

Nathan Perlis^1,2, Bishoy Lawendy¹, Jack Barkin^1,3
Canadian Journal of Urology, Vol.27, No.2, pp. 10185-10191, 2020
Abstract There is increasing evidence to support the use of multiparametric magnetic resonance imaging (MRI) in men at risk for clinically significant prostate cancer to help identify lesions and inform biopsy. Randomized, level 1 evidence demonstrates that men who are managed with MRI and MRI-ultrasound fusion targeted biopsy (MRF-TB) have more clinically significant prostate cancer and less clinically insignificant prostate cancer detected and avoid biopsy altogether more often than men who undergo systematic, whole-gland prostate biopsy (SPB). Furthermore, strategies that incorporate MRF-TB have lower rates of upgrading on radical prostatectomy compared to SPB. However, generalizing this… More >

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RESIDENT’S CORNER

Danielle Anne Jenkins¹, Jesse Ory², Tarek Rahmeh³, Matthew Ryan Acker⁴
Canadian Journal of Urology, Vol.27, No.2, pp. 10192-10194, 2020
Abstract Adrenal cavernous hemangiomas are a rare, benign, and non-functional tumor. We report a case of a 62-year-old male who presented with right upper quadrant and flank pain. Physical examination revealed a fullness of the right upper quadrant. Both computed tomography and magnetic resonance imaging suggested a hemangioma originating from the liver. During angiography with the intent of embolization, it was discovered that the vascular supply was consistent with an adrenal mass rather than a hepatic origin. The patient was referred to Urology and underwent curative right open adrenalectomy and nephrectomy. Histopathology confirmed the diagnosis of More >

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RESIDENT’S CORNER

Kristen McAlpine¹, Stephen E. Ryan², Matthew Roberts¹, Humberto R. Vigil¹
Canadian Journal of Urology, Vol.27, No.2, pp. 10195-10198, 2020
Abstract Emphysematous pyelonephritis is a life-threatening, urologic emergency. We present the case of a 54-year-old female who was found to have a large volume of air in her renal vein and inferior vena cava from severe emphysematous pyelonephritis. In this case report, the medical and operative management of this patient are reviewed, and the literature on the management of emphysematous pyelonephritis is summarized. More >

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