Osteoporosis and fractures after androgen deprivation initiation for prostate cancer
John B. Malcolm1, Ithaar H. Derweesh1, Matthew C. Kincade1, Christopher J. DiBlasio1, Kimberly D. Lamar2, Robert W. Wake1, Anthony L. Patterson1
Canadian Journal of Urology, Vol.14, No.3, pp. 3551-3559, 2007
Abstract Introduction: Androgen deprivation therapy (ADT) is widely utilized for treatment of localized and advanced prostate cancer (CaP). ADT is associated with increased rates of osteoporosis; however, its impact on fracture risk is not completely understood. We investigated incidence and predisposing factors for osteoporosis and fractures in a large, contemporary, single institution series of patients treated with ADT for CaP.
Methods: We retrospectively reviewed medical records of all patients who received ADT for CaP between 1/1989 and 7/2005. Primary endpoints of investigation were osteoporosis and non-pathologic fractures. Independent variables included age, race, body mass index (BMI), pretreatment… More >