Open Access

EDITORIAL

Leonard G. Gomella
Canadian Journal of Urology, Vol.29, No.6, pp. 11340-11341, 2022
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LEGENDS IN UROLOGY

Helen E. O’Connell
Canadian Journal of Urology, Vol.29, No.6, pp. 11342-11344, 2022
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BOOK REVIEW

Scott G. Hubosky
Canadian Journal of Urology, Vol.29, No.6, pp. 11345-11345, 2022
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LETTER

Anessa Sax-Bolder, Stephanie J. Kielb, Granville L. Lloyd
Canadian Journal of Urology, Vol.29, No.6, pp. 11346-11347, 2022
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ARTICLE

Paul H. Chung¹, Joon Yau Leong¹, Jared J. Wallen², Whitney Stanton³, Niccole Diaz³, Caleb D. Phillips⁴, Gerard D. Henry⁵
Canadian Journal of Urology, Vol.29, No.6, pp. 11348-11354, 2022
Abstract Introduction: Traditional culture is the current standard-of-care to determine therapeutic antibiotics for patients suffering from penile prostheses (PP) infections. However, approximately 50% of PPs removed for infection are culture negative. Next-generation sequencing (NGS) compares DNA sequences to reference sequences with known microbial taxonomies to identify isolates and report relative abundances. We aim to compare the ability for standard culture and NGS techniques to identify microorganisms and biofilm composition on PPs.
Materials and methods: Ninety-one PPs explanted for mechanical malfunction were included in this study. Devices removed for infection or erosion were excluded. During revision surgery, two specimens… More >

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ARTICLE

Dean S. Elterman¹, Kevin C. Zorn², Naeem Bhojani², Bilal Chughtai³
Canadian Journal of Urology, Vol.29, No.6, pp. 11355-11360, 2022
Abstract Introduction: The safety and efficacy of low dose methoxyflurane disposable inhaler (Penthrox) was assessed in this study of men undergoing Rezum water vapor thermal therapy (WVTT).
Material and methods: An open-labeled, single-center study was conducted to demonstrate the safety and efficacy of using methoxyflurane inhaler during a Rezum procedure. Patients assessed current pain intensity using a 10-point Visual Analog Scale (VAS) of Pain at 4 timepoints including (1) before any medication, (2) initially after insertion of the rigid cystoscope and before any Rezum treatment, (3) immediately after final injection of Rezum treatment and (4) at discharge. Patients… More >

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ARTICLE

Jeffrey Lee, Elie Kaplan-Marans, Dhaval Jivanji, Daniel Tennenbaum, Ariel Schulman
Canadian Journal of Urology, Vol.29, No.6, pp. 11361-11365, 2022
Abstract Introduction: Flexible cystoscopes can be multi-use devices that visually inspect genitourinary structures such as the bladder and urethra. The objective of this study is to characterize the adverse events and associated device malfunctions of reusable flexible cystoscopes and to provide information on contamination and post-procedural infections.
Materials and methods: The Manufacturer and User Facility Device Experience (MAUDE) database was queried for all adverse events and device malfunctions related to the use of flexible cystoscopes between January 2015 and December 2020. The MAUDE adverse event classification system was used to standardize the severity of complications and special focus… More >

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ARTICLE

Azadeh Nazemi, Jesse Persily, James S. Wysock
Canadian Journal of Urology, Vol.29, No.6, pp. 11366-11370, 2022
Abstract Introduction: To consolidate reported information on presentation, diagnosis, and treatment modalities in testicular schistosomiasis (TS) to provide a reference tool for this rare disease.
Materials and methods: A comprehensive PubMed search was performed using PRISMA guidelines, which yielded 21 articles detailing 22 cases of TS.
Results: Testicular schistosomiasis remains a rare disease, presenting at a variety of ages (median age 27). All reports of this condition are associated with exposure to an endemic area. The most common presenting symptoms include nonspecific testicular swelling (54.5%) followed by a testicular mass/nodule (18.4%). Diagnosis relies upon clinical suspicion due to low… More >

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ARTICLE

Matthew I. Buell^1,*, Akin S. Amasyali^1,*, Natalie Chen², Joshua D. Belle¹, Mohamed Keheila¹, Elizabeth A. Baldwin¹, Cayde Ritchie¹, D. Duane Baldwin¹
Canadian Journal of Urology, Vol.29, No.6, pp. 11371-11377, 2022
Abstract Introduction: During in situ lower pole laser lithotripsy, the dependent location may result in increased challenge fragmenting stones and a risk for stone regrowth if residual fragments remain. The purpose of this study was to compare the thulium fiber laser (TFL) with the holmium laser (HL) for in situ lower pole lithotripsy.
Materials and methods: In a 3D printed kidney benchtop model, sixty 1 cm BegoStones were placed in the lower pole and fragmented in situ until fragments passed through a 2 x 2 mm mesh. Laser lithotripsy was performed using twelve energy, frequency and fiber size… More >

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ARTICLE

Andrés Ortíz Restrepo¹, Jeffrey S. Ross², Philippe E. Spiess^3,4,5, Andrea Necchi⁶, Roger Li⁴, Herney Andrés García-Perdomo^1,7
Canadian Journal of Urology, Vol.29, No.6, pp. 11378-11383, 2022
Abstract Introduction: Urothelial carcinoma (UC) is the fourth most prevalent malignancy in adults, accounting for 2.1% of cancer-related deaths. We aimed to describe the most frequent telomerase reverse transcriptase (TERT) gene mutations in this type of cancer and their relationship with the prognosis and treatment of this disease.
Materials and methods: We performed a search strategy in Medline and Embase with the following keywords: telomerase reverse transcriptase (TERT) gene and upper tract UC. We included reviews and observational studies to support the statements throughout the manuscript.
Results: The transcriptional activation of the TERT gene and subsequent telomerase activity is… More >

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ARTICLE

Navin Shah¹, Vladimir Ioffe², Joshua C. Chang³
Canadian Journal of Urology, Vol.29, No.6, pp. 11384-11390, 2022
Abstract Introduction: To compare prostate biopsy (Pbx) characteristics, before and after the 2012 United States Preventive Services Task Force (USPSTF) prostate cancer screening guidelines in our practice.
Materials and methods: We completed a retrospective comparative analysis of 1703 sequential patients that had a Pbx in 2010 to 2012 (3 years) with 1006 patients biopsied in 2018, 2019 and 2021 (3 years). Data from a total of 2709 Pbx was collected on patient age, race, prostate-specific antigen (PSA), digital rectal examination (DRE) and Gleason sum score (GSS). The data was analyzed to determine whether the 2012 USPSTF screening recommendations… More >

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ARTICLE

Yash B. Shah¹, Cassra B. Clark^1,2, Andrew Shumaker¹, Andrew A. Denisenko¹, Samuel Alfonsi¹, Zachary Prebay¹, Joseph Schultz¹, Vasil Mico¹, Vishal Swaminathan¹, Roy Wang¹, James R. Mark¹, Edouard J. Trabulsi¹, Costas D. Lallas¹, Mark J. Mann¹, Hanan Goldberg³, Thenappan Chandrasekar^1,*
Canadian Journal of Urology, Vol.29, No.6, pp. 11391-11393, 2022
Abstract Introduction: Wallis et al (JAMA 2017) demonstrated use of antithrombotic medications (ATMs) is associated with increased prevalence of hematuria-related complications and subsequent bladder cancer diagnosis within 6 months. Stage of diagnosis was lacking in this highly publicized study. This study examined the association of ATM use on bladder cancer stage at the time of diagnosis.
Materials and methods: We completed a retrospective chart review of patients with a bladder cancer diagnosis at our institution. Patient demographics and bladder cancer work up information were assessed. Patients were stratified based on use of ATMs at time diagnosis. Descriptive statistics… More >

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RESIDENT’S CORNER

Christopher P. Dall¹, Bradley R. Webster², Michael W. Helbig³, Mark W. Ball²
Canadian Journal of Urology, Vol.29, No.6, pp. 11394-11398, 2022
Abstract Abnormal inferior vena cava (IVC) anatomy may present unique challenges for urologists when performing retroperitoneal surgery. Duplication of the IVC is one such anomalous variation and can be found in up to 3% of the population. Misunderstanding of the implications of this aberrant anatomy may lead to intraoperative or postoperative complications. Here, we present two cases of patients undergoing renal surgeries with duplicate IVC. We then review the embryologic origin and anatomic findings in those with abnormal IVC anatomy as well as discuss the surgical implications and considerations for urologists. More >

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RESIDENT’S CORNER

Halle Foss¹, Radhika Ragam¹, W. Kevin Kelly², Leonard G. Gomella¹
Canadian Journal of Urology, Vol.29, No.6, pp. 11399-11401, 2022
Abstract We report the case of a 61-year-old male with metastatic prostate cancer who presented with urinary retention secondary to subdermal penile and corpora cavernosa metastases with neuroendocrine transformation of his metastatic hormone sensitive prostate cancer. We highlight the presentation, diagnosis, and management of this rare condition. More >

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