Evolving understanding and categorization of prostate cancer: preventing progression to metastatic castration-resistant prostate cancer: RADAR IV
E. David Crawford1, Gerald Andriole2, Stephen J. Freedland3, Marc Garnick4, Leonard G. Gomella5, Jonathan Henderson6, Celestia (Tia) Higano7, Andrew Karim Kader8, Christopher Kane9, Thomas E. Keane10, Phillip J. Koo11, Daniel P. Petrylak12, Robert E. Reiter13, Susan F. Slovin14, Evan Y. Yu15
Canadian Journal of Urology, Vol.27, No.5, pp. 10352-10362, 2020
Abstract Introduction: To interpret data and update the traditional categorization of prostate cancer in order to help treating clinicians make more informed decisions. These updates include guidance regarding how to best use next generation imaging (NGI) with the caveat that the new imaging technologies are still a work in progress.
Materials and methods: Literature review.
Results: Critical goals in prostate cancer management include preventing or delaying emergence of distant metastases and progression to castration-resistant disease. Pathways for progression to metastatic castration-resistant prostate cancer (mCRPC) involve transitional states: nonmetastatic castration-resistant prostate cancer (nmCRPC), metastatic hormone-sensitive prostate cancer (mHSPC), and oligometastatic… More >