Open Access

EDITORIAL

Gabriel P. Haas
Canadian Journal of Urology, Vol.14, No.5, pp. 3668-3668, 2007
Abstract This article has no abstract. More >

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REVIEW

Nicolas Barry Delongchamps, Michaël Peyromaure
Canadian Journal of Urology, Vol.14, No.5, pp. 3669-3677, 2007
Abstract Background: Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis, but has also been implicated in pathological angiogenesis associated with renal cell carcinoma (RCC) and prostate cancer (PCa).
Material and methods: This review of literature underlines the recent advances in the understanding of how VEGF acts through these two malignancies, its potential value as a diagnostic and prognostic marker, as well as the development of new therapeutic strategies targeting the VEGF pathway.
Results: In RCC, VHL gene inactivation mediates overexpression of VEGF. Multiple approaches to block VEGF signaling in kidney cancer have been tested.… More >

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ARTICLE

Derek Ottem, Lynn Stothers
Canadian Journal of Urology, Vol.14, No.5, pp. 3678-3683, 2007
Abstract Aims: 1) To describe the anatomy of the obturator canal and variations in placement of the obturator nerve, artery and vein and 2) To record the proximity of these structures to the optimal point of placement of the transobturator tape (TOT) trochar.
Methods: Eighteen obturator foramens were dissected in nine female cadavers. The obturator nerve, artery and vein were exposed as they entered the foramen. Orientation of the obturator nerve, artery and vein from medial to lateral were recorded. Obturator arterial and venous branches > 1 mm crossing the obturator membrane were noted. Usual placement of… More >

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ARTICLE

Prem A. Ramakrishnan, Mohammed Medhat, Younis H. Al-Bulushi, Priti Nair, Ahmed Al-Kindy
Canadian Journal of Urology, Vol.14, No.5, pp. 3684-3691, 2007
Abstract Introduction: Pediatric urolithiasis is relatively uncommon and limited information is available on the application of minimally invasive management modalities in young children. We present a single centre experience with extracorporeal shockwave lithotripsy (ESWL) for infants with upper urinary tract calculi.
Material and methods: A total of 74 infants aged 3 months to 24 months with upper urinary tract calculi were treated with ESWL under general anesthesia using the Wolf 2500 and the 2501 Piezolith lithotriptors over a 14 and a half-year period. Patient and stone characteristics, risk factors for urolithiasis, treatment parameters, clinical outcomes and long-term follow-up… More >

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ARTICLE

S. Marwaha, P. M. Venner, S. A. North
Canadian Journal of Urology, Vol.14, No.5, pp. 3692-3696, 2007
Abstract Objective: The primary objective was to evaluate the effect of etoposide dose in a 3-day cisplatin/etoposide/bleomycin (PEB) regimen on progression free survival (PFS) and overall survival (OS). Secondary objectives were to determine the impact of a paclitaxel-based salvage regimen on OS and to compare the risk distribution of germ cell patients seen at a tertiary care center to that quoted in the International Germ Cell Consensus Classification (IGCCC).
Methods: A retrospective chart review of all 302 metastatic germ cell patients requiring cisplatin-based chemotherapy between January 1980 and December 2004 was conducted. Data collected on initial treatment… More >

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Open Access

MINIMALLY INVASIVE AND ROBOTIC SURGERY

Lambda P. Msezane, Ofer N. Gofrit, Shang Lin, Arieh L. Shalhav, Gregory P. Zagaja, Kevin C. Zorn
Canadian Journal of Urology, Vol.14, No.5, pp. 3697-3701, 2007
Abstract Introduction: Pre-operative prediction of pathological stage represents the cornerstone of prostate cancer management. Patient counseling is routinely based on pre-operative PSA, Gleason score and clinical stage. In this study, we evaluated whether prostate weight (PW) is an independent predictor of extracapsular extension (ECE) and positive surgical margin (PSM).
Methods: Between February 2003 and November 2006, 709 men underwent robotic-assisted laparoscopic radical prostatectomy (RLRP). Pre-operative parameters (patient age, pre-operative PSA, biopsy Gleason score, clinical stage) as well as pathological data (prostate weight, pathological stage) were prospectively gathered after internal-review board (IRB) approval. Evaluation of the influence of… More >

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Open Access

CASE REPORT

Kartik Prabhakaran, Bruce L. Jacobs, Marc C. Smaldone, Michael E. Franks
Canadian Journal of Urology, Vol.14, No.5, pp. 3702-3704, 2007
Abstract Stuttering priapism is a clinical phenomenon that occurs commonly in certain patient populations, including sickle cell anemia and other hematologic dyscrasias. Although the mechanism is still not completely understood, treatment is focused on prevention of recurrence in the outpatient setting, and immediate detumescence and minimizing corporal fibrosis in the acute setting. We present a case of stuttering priapism in a 44 year-old male with hereditary spherocytosis and discuss the pathophysiology and clinical management of this entity. More >

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RESIDENT’S CORNER

Kenneth G. Nepple, Bernard Fallon
Canadian Journal of Urology, Vol.14, No.5, pp. 3705-3706, 2007
Abstract The presence of a foreign body in the urinary tract may serve as a nidus for stone formation. A 40-year-old male was found on CT scan to have a 2.4 cm stone in his Indiana pouch urinary diversion. As the stone was fragmented during endoscopic lithotripsy, a metallic round object was visualized, which was subsequently established to be a metallic ball bearing. Upon questioning after the procedure, the patient reported that 4 years earlier he had been accidentally shot with a blow dart gun and the “miraculous hit” went directly into his Indiana pouch stoma. More >

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RESIDENT’S CORNER

Can Talug, Jeffrey Mullins, Susan E. Saunders, Stanley Zaslau
Canadian Journal of Urology, Vol.14, No.5, pp. 3707-3709, 2007
Abstract In a patient with a prior history of pancreatitis or abdominal trauma, radiographic imaging may only show abnormalities in the urinary tract. When these patients are first seen with subcapsular or perinephric fluid collections, percutaneous drainage can be both diagnostic and therapeutic. More >

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RESIDENT’S CORNER

Derek J. Matoka, Timothy D. Averch
Canadian Journal of Urology, Vol.14, No.5, pp. 3710-3714, 2007
Abstract Background: Photoselective laser vaporization of the prostate (PVP) is recognized as an alternative for the surgical management of BPH. Our experience suggests a higher incidence of persistent irritative symptoms than expected. Characteristics of our population were evaluated to determine whether postoperative symptomatology could be predicted.
Methods: We retrospectively reviewed those patients who underwent PVP at our institution between June 2004 and February 2006. Lower urinary tract symptoms as measured by the American Urological Association Symptom Index (AUA-SI) score and quality of life (QoL) score were recorded. In addition, peak urinary flow rate (Qmax) and ultrasound prostate… More >

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EDITORIAL

Richard Casey
Canadian Journal of Urology, Vol.14, No.5, pp. 3715-3715, 2007
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CLINICAL TRIALS

Eric Winquist, Mary J. Mackenzie, George Rodrigues
Canadian Journal of Urology, Vol.14, No.5, pp. 3716-3722, 2007
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LETTER

Mary J. MacKenzie, George Rodrigues, Eric Winquist
Canadian Journal of Urology, Vol.14, No.5, pp. 3723-3723, 2007
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