A prospective study of health-related quality of life outcomes among men treated for intermediate- and high-risk prostate cancer: the impact of primary and secondary therapies
Mazen Alsinnawi1, Jennifer Cullen2,3,4, Lauren M. Hurwitz2,3, Katherine E. Levie2,3, John F. Burns1, Inger L. Rosner2,5, Timothy C. Brand2,6, Sean Stroup2,7, Joseph R. Sterbis2,8, Kevin Rice2,5, Galen Conti2,3, Christopher R. Porter1,2
Canadian Journal of Urology, Vol.26, No.4, pp. 9809-9820, 2019
Abstract Introduction: To assess the impact of primary and secondary therapies for high- and intermediate-risk prostate cancer on health-related quality of life (HRQoL).
Materials and methods: A prospective study was initiated in 2007 at Center for Prostate Disease Research Multicenter National Database sites. Longitudinal patterns in HRQoL from baseline (pre-treatment) to 5 years post-diagnosis were examined for patients with high- and intermediate-risk prostate cancer, treated by radical prostatectomy (RP) or external beam radiation therapy (EBRT). Change in HRQoL was modeled using linear regression models fit with generalized estimating equations. The probability of maintaining HRQoL was compared between patients… More >