Delay in surgical therapy for clinically localized prostate cancer and biochemical recurrence after radical prostatectomy
Robert K. Nam1, Michael A. S. Jewett1, Murray D. Krahn2,
Michael A. Robinette1, John Tsihlias1, Ants Toi3,
Minnie Ho1, Andrew Evans4, Joan Sweet4,
John Trachtenberg1
Canadian Journal of Urology, Vol.10, No.3, pp. 1891-1898, 2003
Abstract Background: In Canada, waiting times for cancer care have been increasing, particularly for patients with genitourinary malignancies. We examined whether delay from diagnosis for patients undergoing surgery for clinically localized prostate cancer affects cancer cure rates.
Methods: We conducted a historical cohort study among 645 patients who underwent radical prostatectomy between 1987 and 1997, using biochemical recurrence (PSA elevation) and metastasis as endpoints. We examined whether patients who underwent surgery ≥3 months (delayed surgery group) from the date of diagnosis had reduced recurrence-free survival, compared to patients who had surgery <3 months (early surgery group) from the… More >