Salvage therapy for locally recurrent prostate cancer after radiation
David M. Marcus1,5, Daniel J. Canter2,5, Ashesh B. Jani1,2,5, Ryan W. Dobbs2, David M. Schuster3, Bradley C. Carthon4,5, Peter J. Rossi1,2,5
Canadian Journal of Urology, Vol.19, No.6, pp. 6534-6541, 2012
Abstract Introduction: External beam radiotherapy (EBRT) is widely utilized as primary therapy for clinically localized prostate cancer. For patients who develop locally recurrent disease after EBRT, local salvage therapy may be indicated. The primary modalities for local salvage treatment in this setting include radical prostatectomy, cryotherapy, and brachytherapy. To date, there is little data describing outcomes and toxicity associated with each of these salvage modalities.
Materials and methods: A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. We focused on prospective trials… More >