Open Access

BOOK REVIEW

Fahri Saatcioglu
Canadian Journal of Urology, Vol.19, No.6, pp. 6529-6529, 2012
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EDITORIAL

Leonard G. Gomella
Canadian Journal of Urology, Vol.19, No.6, pp. 6530-6530, 2012
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LEGENDS IN UROLOGY

John J. Mulcahy
Canadian Journal of Urology, Vol.19, No.6, pp. 6531-6533, 2012
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REVIEW

David M. Marcus^1,5, Daniel J. Canter^2,5, Ashesh B. Jani^1,2,5, Ryan W. Dobbs², David M. Schuster³, Bradley C. Carthon^4,5, Peter J. Rossi^1,2,5
Canadian Journal of Urology, Vol.19, No.6, pp. 6534-6541, 2012
Abstract Introduction: External beam radiotherapy (EBRT) is widely utilized as primary therapy for clinically localized prostate cancer. For patients who develop locally recurrent disease after EBRT, local salvage therapy may be indicated. The primary modalities for local salvage treatment in this setting include radical prostatectomy, cryotherapy, and brachytherapy. To date, there is little data describing outcomes and toxicity associated with each of these salvage modalities.
Materials and methods: A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. We focused on prospective trials… More >

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ARTICLE

Ricardo Palmerola¹, Paul Smith², Vanessa Elliot², Carl T. Reese², Frank B. Mahon², Lewis E. Harpster², Nikolina Icitovic¹, Jay D. Raman^2,3
Canadian Journal of Urology, Vol.19, No.6, pp. 6542-6547, 2012
Abstract Introduction: Indications for prostate needle biopsy (PNB) include elevated serum prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE). We evaluated a contemporary cohort of men undergoing PNB to determine cancer detection rates when stratified by DRE status.
Materials and methods: The charts of 806 men who underwent a PNB were reviewed. Serum PSA was categorized as normal or abnormal according to age-specific criteria. A normal DRE was defined as a smooth, age-appropriate, asymmetric, or uniformly enlarged prostate. An abnormal DRE was defined by either a nodule or induration. Sensitivity, specificity, and predictive values were determined for… More >

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ARTICLE

Chen-Ye Tang, Qiang Fu, Ren-Jie Cui, Xian-Jun Sun
Canadian Journal of Urology, Vol.19, No.6, pp. 6548-6553, 2012
Abstract Introduction: To investigate factors correlated with erectile dysfunction (ED) in patients with traumatic urethral strictures undergoing end-to-end anastomotic urethroplasty (AU).
Materials and methods: Between January 2010 and January 2011, 41 patients with urethral strictures resulting from pelvic fracture urethral distraction defects underwent end-to-end AU. The abridged International Index of Erectile Function (IIEF-5) was used to subjectively assess erectile function at admission and 2 weeks postoperatively.
Results: Pre- and post-injury IIEF-5 scores differed significantly (23.54 ± 1.45 versus 10.02 ± 3.57; p < 0.0001), but pre- and postoperative scores did not (10.02 ± 3.57 versus 9.29 ± 4.14; p… More >

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ARTICLE

Christopher B. Allard¹, Anatoly Shuster², Jehonathan H. Pinthus³, Forough Farrokhyar⁴, A. Raees¹, Michael Patlas², Edward D. Matsumoto¹, J. Paul Whelan¹
Canadian Journal of Urology, Vol.19, No.6, pp. 6554-6559, 2012
Abstract Introduction: Obese patients are at increased risk for renal stones as well as treatment failures due to increased skin-to-stone distances (SSD) and harder stone compositions. We investigated the relationships between obesometric parameters (body mass index [BMI], body fat distribution and obesity-related hormone levels) with SSD and stone hardness.
Materials and methods: We prospectively enrolled patients undergoing stone interventions at our institution. Computed tomography (CT) scans were analyzed; adipose tissue was identified according to Hounsfield units (HU) and separated into subcutaneous (SAT) and visceral (VAT) components. The pixels were averaged at three levels to calculate fat distribution: %VAT… More >

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ARTICLE

Shaun E. L. Wason¹, John D. Seigne¹, Alan R. Schned², Vernon M. Pais Jr¹
Canadian Journal of Urology, Vol.19, No.6, pp. 6560-6565, 2012
Abstract Introduction: We sought to assess the adequacy of surgical specimens obtained utilizing the BIGopsy (Cook Medical, Bloomington, IN, USA) biopsy forceps both ex vivo and in vivo and compare them to traditional 3Fr biopsy forceps in patients with suspected upper tract urothelial carcinoma.
Materials and methods: Patients undergoing nephroureterectomy for suspected upper tract transitional cell carcinoma were recruited. Surgical specimens, immediately after extirpation were examined and alternatively biopsied ex vivo with the BIGopsy and 3Fr biopsy forceps. We then retrospectively reviewed our most recent experience with ureteroscopic biopsy. The biopsy device, size, depth, grade, stage, pathologic diagnosis… More >

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COMMENTARY

Francis X. Keeley Jr
Canadian Journal of Urology, Vol.19, No.6, pp. 6566-6566, 2012
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ARTICLE

Malik Elharram¹, David Margel², Antonio Finelli², John Trachtenberg², Andrew Evans³, Theodorus H. van der Kwast³, Joan M. Sweet², Neil Fleshner²
Canadian Journal of Urology, Vol.19, No.6, pp. 6567-6572, 2012
Abstract Introduction: The clinical significance of perineural invasion (PNI) on prostate needle biopsy is controversial. The aim of this present study is to determine the role of PNI on prostate biopsy in predicting adverse findings at radical prostatectomy in a recent cohort of screen detected prostate cancer.
Materials and methods: We analyzed 470 patients diagnosed with prostate cancer from a prospectively maintained database at Princess Margaret Hospital. Out of the 470 patients diagnosed with prostate cancer, 139 underwent radical prostatectomy. Pathological specimens were examined, and perineural invasion was identified as carcinoma tracking along or around a nerve in… More >

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RESIDENT’S CORNER

Steve Sterious¹, Marc C. Smaldone¹, Elizabeth Plimack², Robert G. Uzzo¹, Daniel Canter³, Alexander Kutikov¹
Canadian Journal of Urology, Vol.19, No.6, pp. 6578-6580, 2012
Abstract Surgical excision is the gold standard therapy for clinically localized renal masses. Nevertheless, prognostication of the natural history of untreated renal cell carcinoma (RCC) remains a clinical challenge. While active surveillance (AS) has emerged as a viable treatment option in select patients with localized tumors and significant competing mortality risks, long term follow up data to assess the risk of disease progression are limited. We present a case of a localized, clinical stage T2 renal mass progressing to regional and systemic disease over 6 years, demonstrating that kinetics of disease progression may be prolonged and More >

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RESIDENT’S CORNER

Shivam Joshi, Ahmed M. Mansour, Ahmed Eldefrawy, Mark S. Soloway
Canadian Journal of Urology, Vol.19, No.6, pp. 6581-6583, 2012
Abstract Primary lymphoma of the spermatic cord is rare. We report a case of primary lymphoma of the spermatic cord and review the literature. A 77-year-old man presented with a 5 month history of an enlarging right inguino-scrotal mass. On physical exam, the mass involved the spermatic cord. Computerized tomography and magnetic resonance imaging revealed a 10 cm x 4 cm inguinoscrotal mass related to the spermatic cord. A right inguinal orchidectomy with wide local excision was performed. Pathological and immunohistochemical evaluation identified the tumor as a diffuse large B cell lymphoma of the spermatic cord. More >

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RESIDENT’S CORNER

Chandan Kundavaram, Patrick T. Gomella, Kelly A. Healy, Matthew Klinge, Scott Hubosky
Canadian Journal of Urology, Vol.19, No.6, pp. 6584-6586, 2012
Abstract Renal vasculature anomalies can present technical challenges to laparoscopic urologic surgery. The use of preoperative imaging has made it possible to recognize and plan for such aberrant vascular anatomy. We describe a patient with a circumaortic left renal vein who underwent successful laparoscopic radical nephroureterectomy for the management of urothelial carcinoma of the renal pelvis. More >

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CLINICAL TRIALS

Eric Winquist, George Rodrigues
Canadian Journal of Urology, Vol.19, No.6, pp. 6587-6591, 2012
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ARTICLE

Joel H. Hillelsohn¹, Brian Duty², Michael L. Blute Jr.¹, Zhamshid Okhunov³, Mahyar Kashan¹, Robert Moldwin¹, Richard N. Ashley¹
Canadian Journal of Urology, Vol.19, No.6, pp. 6573-6577, 2012
Abstract Introduction: To assess the variability of pre-prostate biopsy prophylaxis among American urologists.
Materials and methods: A survey was electronically mailed to 3355 urologists around the country. Urologists were surveyed on their antibiotic prophylaxis choice, the route and duration of antimicrobial prophylaxis. Additionally they were questioned about their knowledge of local antimicrobial resistance and if rectal enemas were routinely used.
Results: There were 679 (21%) responses to the survey. The survey revealed differences in pre-prostate biopsy prophylaxis among urologists. Ten different classes of antibiotics were used orally, 4 classes intramuscular, 5 classes intravenous, and there was also 14 different More >

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