Open Access

EDITORIAL

James A. Brown
Canadian Journal of Urology, Vol.32, No.4, pp. 237-237, 2025, DOI:10.32604/cju.2025.072192 - 29 August 2025
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LEGENDS IN UROLOGY

Louis R. Kavoussi
Canadian Journal of Urology, Vol.32, No.4, pp. 239-241, 2025, DOI:10.32604/cju.2025.070979 - 29 August 2025
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2429

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ARTICLE

Aysenur Elmali¹, Birhan Demirhan², Caglayan Selenge Beduk Esen³, Ozan Cem Guler⁴, Pervin Hurmuz⁵, Cem Onal^1,4,*
Canadian Journal of Urology, Vol.32, No.4, pp. 243-254, 2025, DOI:10.32604/cju.2025.066700 - 29 August 2025
（This article belongs to the Special Issue: Advances in Molecular Imaging and Targeted Therapies for Prostate Cancer)
Abstract Background: Intermediate-risk prostate cancer (IR-PC) represents a heterogeneous group requiring nuanced treatment approaches, and recent advancements in radiotherapy (RT), androgen deprivation therapy (ADT), and prostate-specific membrane antigen positron emission tomography (PSMA-PET/CT) imaging have prompted growing interest in personalized, risk-adapted management strategies. This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’ practices in managing IR-PC, focusing on RT and imaging modalities to identify trends for personalized treatments. Methods: A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer (PC) cases annually. The 22-item questionnaire covered IR-PC… More >

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432

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REVIEW

Huan Liu^1,#, Yan Li^2,#, Jizhang Qiu¹, Junchao Zhang¹, Huan Lai¹, Xinhua Zhang^1,*
Canadian Journal of Urology, Vol.32, No.4, pp. 255-269, 2025, DOI:10.32604/cju.2025.066523 - 29 August 2025
Abstract Benign prostatic hyperplasia (BPH) represents a prevalent etiology of lower urinary tract symptoms (LUTS) in the male population, clinically defined by a non-malignant proliferation of prostatic tissue. While BPH exhibits a high prevalence among older male populations globally, the precise underlying mechanisms contributing to its development remain incompletely elucidated. Mitochondria, essential organelles within eukaryotic cells, are critical for cellular bioenergetics, the regulation of reactive oxygen species (ROS) generation, and the modulation of cell death pathways. The maintenance of mitochondrial homeostasis involves a complex interplay of processes. By synthesizing previous literature, this review discusses mitochondrial homeostasis More >

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ARTICLE

Stamatios Katsimperis^1,*, Lazaros Tzelves¹, Georgios Feretzakis², Themistoklis Bellos¹, Panagiotis Deligiannis¹, Andreas Skolarikos¹, Athanasios Papatsoris¹, Iraklis Mitsogiannis¹
Canadian Journal of Urology, Vol.32, No.4, pp. 271-282, 2025, DOI:10.32604/cju.2025.066395 - 29 August 2025
Abstract Background: Accurate complication reporting in endourology remains challenging, with the Clavien-Dindo Classification and Comprehensive Complication Index being the most commonly used systems. This study aimed to compare surgical outcomes and complication reporting in ureterolithotripsy (URL), percutaneous nephrolithotomy (PCNL), and extracorporeal shock wave lithotripsy (ESWL) using both systems. Methods: This prospective, single-center, non-interventional study included 473 patients undergoing URL, PCNL, or ESWL from October 2022 to October 2024. Demographic, stone-related, and procedural variables were recorded. Complications were classified using the CDC, and cumulative morbidity was assessed using CCI. Statistical analyses, including univariate and multivariate regression, were… More >

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344

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ARTICLE

Fabrizio Di Maida^1,*, Francesca Oriti¹, Antonio Andrea Grosso¹, Francesco Sessa², Daniele Paganelli¹, Vincenzo Salamone¹, Sara Costagli¹, Francesca Solazzi¹, Luca Lambertini¹, Matteo Salvi¹, Michele Di Dio³, Andrea Mari¹, Rino Oriti¹, Andrea Minervini¹
Canadian Journal of Urology, Vol.32, No.4, pp. 283-292, 2025, DOI:10.32604/cju.2025.065984 - 29 August 2025
Abstract Background: The surgical management of patients with benign prostatic hyperplasia (BPH) has considerably evolved through recent years. Nonetheless, benefits and harms of several laser procedures are still to be determined. The study aimed to report perioperative and early functional results of patients treated with anatomical photo vaporization of the prostate (aPVP). Methods: Data from consecutive patients treated with aPVP by using a 180-W XPS GreenLight laser were prospectively collected in a single tertiary center between 2020 and 2023. The surgical procedure was divided into a modular step-by-step fashion. Patients were asked to complete self-administered questionnaires… More >

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361

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ARTICLE

Brian Gilmartin^*, Sorcha O’Meara, Michelle Horan, Frank T. D’Arcy, Catherine M. Dowling
Canadian Journal of Urology, Vol.32, No.4, pp. 293-298, 2025, DOI:10.32604/cju.2025.065805 - 29 August 2025
Abstract Background: Radiation cystitis is a well-known complication resulting from radiotherapy for pelvic malignancies. It remains a challenging condition to treat and is associated with significant morbidity for patients. We aimed to establish the economic cost burden of presentations and investigations associated with radiation cystitis over a two-year period to a tertiary referral hospital in Ireland. Materials and Methods: A retrospective review of patient charts was performed for radiation cystitis-related presentations and investigations over 24 months. Costs were estimated in consultation with the hospital finance department and using Health Service Executive data on diagnostic-related groups and average More >

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326

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ARTICLE

Iqbal Singh^1,*, Himanshu Agrawal², Vidhi Maurya², Sanjay Gupta², Alpana Raizada³
Canadian Journal of Urology, Vol.32, No.4, pp. 299-308, 2025, DOI:10.32604/cju.2025.064827 - 29 August 2025
Abstract Objectives: Benign prostatic hyperplasia (BPH) is a common benign tumor in men, with an age-related prevalence of multifactorial etiology. The present study aimed to accurately assess and predict the effect of co-existing metabolic syndrome (MtS) upon treatment outcomes of combination medical therapy in select patients of lower urinary tract symptoms (LUTS) due to BPH. Methods: After obtaining informed consent from the patients, 70 eligible patients with LUTS due to BPH with and without MtS were enrolled in this study from September 2022 to January 2024 from the outpatient clinic at the University College of Medical… More >

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446

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ARTICLE

Tara Morgan^1,*, Brian Calio¹, Rafael Tua Caraccia¹, Daniel Segal², Joshua Kim³, Sarah Attia⁴, Neil B. Desai⁵, Jeffery Gahan¹
Canadian Journal of Urology, Vol.32, No.4, pp. 309-315, 2025, DOI:10.32604/cju.2025.063408 - 29 August 2025
Abstract Background: Radical prostatectomy has long been the treatment of choice for men with clinically significant prostate cancer (PCa) in those with concurrent significant lower urinary tract symptoms (LUTS). For men who meet this description with marked prostatomegaly, we present a multi-institutional proof of concept study describing an alternative pathway of robotic simple prostatectomy (RASP) followed by external beam radiation therapy (EBRT) for the treatment of clinically significant prostate cancer. Methods: A retrospective study was performed of 17 patients with PCa who underwent RASP followed by EBRT at two institutions from 2015–2023. Demographic, peri-operative, and post-radiation… More >

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405

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ARTICLE

Abdullah Alahmari^1,2, Rabea Akram^1,2, Michael Maalouf³, Abdulelah Elsayed⁴, Armand Zini^1,5,*
Canadian Journal of Urology, Vol.32, No.4, pp. 317-323, 2025, DOI:10.32604/cju.2025.064517 - 29 August 2025
Abstract Background: Testicular sperm aspiration (TESA) is a minimally invasive testicular sperm retrieval technique that has been utilized in the treatment of male factor infertility. We sought to evaluate sperm retrieval outcomes of primary and redo TESA in men with severe oligoasthenoteratozoospermia (OAT) and obstructive azoospermia (OA). Methods: This is a retrospective analysis of consecutive TESAs (primary and redo) for men with severe OAT and OA performed between January 2011 and August 2022 at a high-volume infertility center. We compared TESA outcomes in men with severe OAT to those with OA and compared outcomes of men… More >

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342

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ARTICLE

Matthew S. Lee, Trey R. Sledge, Amanda K. Seyer, Robert Qi, Kevin Koo^*
Canadian Journal of Urology, Vol.32, No.4, pp. 325-333, 2025, DOI:10.32604/cju.2025.064255 - 29 August 2025
Abstract While cystolitholapaxy for bladder stones is commonly performed using a transurethral approach, large or complex stone burdens in patients with complex lower urinary tract anatomy may make this inefficient or infeasible. Percutaneous cystolitholapaxy is a safe, effective, minimally invasive alternative for diverse indications, including patients with benign prostatic hyperplasia, urethral stricture disease, closed bladder neck, continent catheterized channel, or other urinary diversion. In this article, we review the indications for and advantages of percutaneous cystolitholapaxy and describe our step-by-step technique for this procedure, including representative imaging and favored equipment. We also discuss preoperative and postoperative More >

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359

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ARTICLE

Connor M. Forbes^1,*, Ben H. Chew¹, K.F. Victor Wong¹, Runhan Ren¹, Yuanyuan Ji², Alexander P. Glaser³, Kazumi Taguchi⁴, Amy E. Krambeck⁵, Marcelino E. Rivera⁶, Ojas Shah⁷, Edouard Tariel⁸, Channa Amarasekera⁵, Shuzo Hamamoto⁴, Dirk Lange¹, Wilson R. Molina⁹, John J. Knoedler¹⁰, Mitchell R. Humphreys¹¹, Karen L. Stern,¹¹
Canadian Journal of Urology, Vol.32, No.4, pp. 335-344, 2025, DOI:10.32604/cju.2025.063577 - 29 August 2025
Abstract Objectives: Previous studies have shown conflicting results concerning the optimal duration of ureteral stenting after endourologic treatment of stone disease, its effect on patient comfort, and the necessity for emergent, unscheduled care. This study assessed the impact of stent duration, sex, and other patient-associated factors on reported pain scores using a large, international prospective registry. Methods: A prospective observational patient registry on ureteral stents from 10 institutions in 4 countries (United States, Canada, France, and Japan) from 2020–2023 was assessed. The primary outcome was Patient-Reported Outcomes Measurement Information System (PROMIS) pain intensity scores administered on… More >

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579

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CASE REPORT

Conor B. Driscoll^*, Nicole Handa, Daniel R. Greenberg, Ziho Lee
Canadian Journal of Urology, Vol.32, No.4, pp. 345-348, 2025, DOI:10.32604/cju.2025.063323 - 29 August 2025
Abstract Penile fracture is a rare clinical entity that occurs secondary to direct trauma to an erect penis, most commonly during sexual intercourse. Specifically, increased pressure within the corpus cavernosa results in rupture of the tunica albuginea. Occasionally, these injuries extend to the urethra and very rarely cause a complete urethral avulsion. Emergent exploration improves post-traumatic erectile function, penile curvature, and prevents painful erections. The traditional approach is a subcoronal circumcising incision to allow for adequate visualization. We present an uncircumcised male with bilateral corporal injuries and complete urethral avulsion who underwent a ventral midline approach More >

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308

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CASE REPORT

Siddharth Marthi^1,*, Muhammad Mukarram¹, Fatemeh Ardeshir-Larijani², Lara Rabih Harik³, Shreyas Subhash Joshi^1,2
Canadian Journal of Urology, Vol.32, No.4, pp. 349-353, 2025, DOI:10.32604/cju.2025.063775 - 29 August 2025
Abstract Tumor-to-tumor metastasis (TTM) is a rare phenomenon in which a secondary tumor colonizes within a primary tumor of a different histogenesis. It is hypothesized that TTM is encouraged by conditions that promote increased cell growth and division in the primary tumor, such as hypervascularity and expression of oncogenic cytokines. However, the exact causes of TTM likely vary on a case-by-case basis and are dependent on the microenvironment of both the primary and secondary tumors. Herein, we present the first reported example of TTM in which a pulmonary neuroendocrine tumor (NET) metastasizes to a renal oncocytoma. More >

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472

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CASE REPORT

Matthew Kwon^1,*, Kathleen Lockhart¹, Hugh Reid², Avi Raman¹
Canadian Journal of Urology, Vol.32, No.4, pp. 355-358, 2025, DOI:10.32604/cju.2025.068631 - 29 August 2025
Abstract Priapism is a rare but potentially serious adverse effect of several medications including chlorpromazine, which is commonly used in the treatment of refractory migraine. We describe three cases of ischaemic priapism occurring in men following intravenous chlorpromazine administration for migraine relief. These cases highlight an important but under-recognised complication that can result in long-term erectile dysfunction if not promptly managed. Clinicians should maintain a high index of suspicion for this adverse effect and ensure patients are appropriately counselled regarding the need for urgent medical review should symptoms arise. More >

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538

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409

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ARTICLE

Marie Chaumel¹, Nicolas Brichart², Franck Bruyère¹, Ali Bourgi^1,*
Canadian Journal of Urology, Vol.32, No.4, pp. 359-366, 2025, DOI:10.32604/cju.2025.066470 - 29 August 2025
Abstract Background: The COVID-19 pandemic disrupted healthcare systems globally, raising concerns about delayed cancer diagnosis and treatment. In France, transurethral resection of bladder tumors (TURBT) was prioritized in national urology guidelines to ensure the timely management of urothelial carcinoma. This study aimed to assess the impact of care reorganization on tumor staging, recurrence, palliative care, and mortality in bladder cancer patients from the pre-pandemic through late-pandemic periods. Methods: We conducted a retrospective multicenter study including all patients who underwent TURBT with histologically confirmed urothelial carcinoma between April and December of 2019 (pre-pandemic), 2020 (early pandemic), 2021… More >

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449