Special Issues
Table of Content

Advances in Molecular Imaging and Targeted Therapies for Prostate Cancer

Submission Deadline: 31 December 2025 View: 601 Submit to Special Issue

Guest Editors

Dr. Hui Lu

Email: huilu@zju.edu.cn

Affiliation: Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China

Homepage:

Research Interests: advanced molecular imaging, novel imaging probes, multimodal imaging strategies, early prostate cancer detection, treatment monitoring, tissue engineering, biomaterials, hydrogels, 3d-printed scaffolds, cancer modeling, targeted drug delivery, regenerative applications

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Dr. zhenfeng Liu

Email: zhenfeng19792003@zju.edu.cn

Affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, 310003, China

Research Interests: PSMA-targeted molecular imaging agents, radioligand therapy (rlt), sensitization strategies, nanotechnology, theranostics, prostate cancer

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Dr. Dengfeng Cheng

Email: cdflyx@163.com

Affiliation: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, 310003, China

Homepage:

Research Interests: medical imaging, nuclear medicine, R&D of radiopharmaceuticals

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Dr. Zhijie Xu

Email: xuzj@zju.edu.cn

Affiliation: Department of Urology, The First Affiliated Hospital, Zhejiang UniversityHangzhou, 310003, China

Research Interests: precision diagnosis, personalized treatment, prostate cancer

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Summary

Prostate cancer remains a leading cause of cancer-related deaths worldwide, necessitating more precise diagnostic and therapeutic strategies. Molecular imaging, particularly PSMA-targeted PET/SPECT, has revolutionized prostate cancer detection and staging, enabling earlier and more accurate diagnosis. Additionally, PSMA-targeted radioligand therapy (RLT) has emerged as a promising treatment for metastatic castration-resistant prostate cancer (mCRPC). Meanwhile, nanotechnology and advanced biomaterials are enhancing drug delivery, theranostics, and multimodal imaging, further improving patient outcomes. This Special Issue will explore cutting-edge research integrating nuclear medicine, molecular imaging, and nanomedicine to advance prostate cancer diagnosis and therapy.

Scope and Themes:
Including but not limit to:
-PSMA-targeted imaging and radioligand therapy
-Novel radiopharmaceuticals and theranostic agents
-Nanoparticle-based drug delivery and imaging
-Molecular imaging for disease progression and treatment monitoring
-Clinical translation and personalized treatment strategies

This Special Issue aims to bridge fundamental research with clinical applications, highlighting innovative approaches to improve prostate cancer management and drive future advancements in precision oncology.


Keywords

PSMA-targeted imaging, radioligand therapy, prostate cancer, molecular imaging, nuclear medicine, theranostics, nanoparticles, PET/SPECT, drug delivery, precision oncology

Published Papers


  • Open Access

    ARTICLE

    PSMA PET/CT-guided pelvic lymph node dissection in patients with unfavorable intermediate- or high-risk prostate cancer

    Eva Donck, Sofie Verbeke, Pieter De Visschere, Valérie Fonteyne, Charles Van Praet, Kathia De Man, Nicolaas Lumen
    Canadian Journal of Urology, DOI:10.32604/cju.2025.068589
    (This article belongs to the Special Issue: Advances in Molecular Imaging and Targeted Therapies for Prostate Cancer)
    Abstract Objectives: PSMA PET/CT (Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography) offers improved accuracy in detecting lymph node invasion (LNI) in prostate cancer (PC) patients, potentially reducing the need for extended pelvic lymph node dissection (ePLND). This study aims to evaluate a patient-tailored care pathway in which ePLND is performed only in patients with unfavorable intermediate- or high-risk PC who are deemed at risk for LNI based on PSMA PET/CT findings. Methods: In this interventional cohort study, 81 patients were managed according to the new care pathway. ePLND was omitted in cases of negative PSMA PET/CT… More >

  • Open Access

    ARTICLE

    National survey of radiotherapy and androgen deprivation therapy strategies with PSMA-PET/CT integration in intermediate-risk prostate cancer: TROD 09-007 study

    Aysenur Elmali, Birhan Demirhan, Caglayan Selenge Beduk Esen, Ozan Cem Guler, Pervin Hurmuz, Cem Onal
    Canadian Journal of Urology, Vol.32, No.4, pp. 243-254, 2025, DOI:10.32604/cju.2025.066700
    (This article belongs to the Special Issue: Advances in Molecular Imaging and Targeted Therapies for Prostate Cancer)
    Abstract Background: Intermediate-risk prostate cancer (IR-PC) represents a heterogeneous group requiring nuanced treatment approaches, and recent advancements in radiotherapy (RT), androgen deprivation therapy (ADT), and prostate-specific membrane antigen positron emission tomography (PSMA-PET/CT) imaging have prompted growing interest in personalized, risk-adapted management strategies. This study by the Turkish Society for Radiation Oncology aims to examine radiation oncologists’ practices in managing IR-PC, focusing on RT and imaging modalities to identify trends for personalized treatments. Methods: A cross-sectional survey was conducted among Turkish radiation oncologists treating at least 50 prostate cancer (PC) cases annually. The 22-item questionnaire covered IR-PC… More >

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