Cross validation of the prostate cancer radiotherapy late toxicity (PCRT) questionnaire with the expanded prostate cancer index composite (EPIC) instrument
George Rodrigues1,2, Glenn Bauman1, Varagur Venkatesan1, Belal Ahmad1, Michael Lock1, Tracy Sexton1, David D’Souza1, Larry Stitt2, Somaya Eid1,2
Canadian Journal of Urology, Vol.18, No.4, pp. 5802-5810, 2011
Abstract Introduction: A 29-item prostate cancer radiotherapy (PCRT) questionnaire with genitourinary (GU), gastrointestinal (GI), and sexual (S) domains has been previously validated for the assessment of late toxicity health-related quality of life (HRQoL) effects. The study objective was to cross-validate the PCRT domains versus the expanded prostate cancer index composite (EPIC) questionnaire urinary (U), bowel (B), hormonal (H), and S subscales.
Methods and materials: A single-institution cross-sectional PCRT patient cohort was surveyed. Descriptive and intra- and inter-class correlation coefficient statistics for the various EPIC and PCRT HRQoL domain scores were generated. Univariable and multivariable Cox and logistic regressions… More >