Home / Journals / CJU / Vol.18, No.4, 2011
Special Issues
Table of Content
  • Open AccessOpen Access

    EDITORIAL

    Immunotherapy for Prostate Cancer

    Bob Djavan
    Canadian Journal of Urology, Vol.18, No.4, pp. 5763-5763, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    LEGENDS IN UROLOGY

    LEGENDS IN UROLOGY

    Lawrence H. Einhorn
    Canadian Journal of Urology, Vol.18, No.4, pp. 5764-5765, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    BOOK REVIEW

    Winning the Battle Against Prostate Cancer: Getting the Treatment That is Right for You

    Gerald Chodak
    Canadian Journal of Urology, Vol.18, No.4, pp. 5766-5766, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    REVIEW

    New treatment options for castrate-resistant prostate cancer: a urology perspective

    Leonard G. Gomella, Francisco Gelpi, William Kevin Kelly
    Canadian Journal of Urology, Vol.18, No.4, pp. 5767-5777, 2011
    Abstract Introduction: Castrate-resistant prostate cancer (CRPC) is the most clinically advanced form of prostate cancer. Prior to 2004, treatment options for patients with CRPC were limited to palliative care with mitoxantrone. However, two phase III trials in 2004 showed improved survival with docetaxel compared with mitoxantrone in patients with metastatic CRPC. Docetaxel remains the current standard chemotherapy for CRPC.
    Materials and methods: A literature review was conducted to ascertain agents recently approved or in development for CRPC as well as several treatment algorithms being developed in this patient population.
    Results: Recently, the US Food and Drug Administration (FDA) approved… More >

  • Open AccessOpen Access

    REVIEW

    An overview on preclinical and clinical experiences with photodynamic therapy for bladder cancer

    Nazila Yavari1, Stefan Andersson-Engels2, Ulrika Segersten1, Per-Uno Malmstrom1
    Canadian Journal of Urology, Vol.18, No.4, pp. 5778-5786, 2011
    Abstract Photodynamic therapy (PDT) is one of the most interesting methods of photo treatment. In general, PDT is a modality for the treatment of non-muscle invasive tumors. PDT is very well suited in managing bladder cancer, as the bladder is accessible by endoscopy and the tumors are most often limited to the mucosa or sub-mucosa. PDT is likely more useful for patients with recurrent tumors after conventional therapies, as well as for patients with diffuse non-muscle invasive bladder carcinomas that are refractory to standard treatments before the commitment to radical extirpative surgery, particularly in patients at More >

  • Open AccessOpen Access

    REVIEW

    Injection of botulinum toxin type Ain the urethral sphincter to treat lower urinary tract dysfunction: review of indications, techniques and results: 2011 update

    Wally Mahfouz1, Gilles Karsenty2, Jacques Corcos1
    Canadian Journal of Urology, Vol.18, No.4, pp. 5787-5795, 2011
    Abstract Introduction: The first application of botulinum toxin type A (BoNT-A) in urology was its injection into the urinary sphincter to treat neurogenic detrusor-sphincter dyssynergia (DSD) in quadriplegic men. Since that first report by Dyskatra et al in 1988, the results of focal BTA injections into the sphincter, the bladder wall and lately into the prostate have raised the interest of the urology community in this promising new therapeutic modality. This is an evidence-based review of the current indications, techniques and outcomes of BTA injections into the urethral sphincter.
    Materials and methods: The Medline database was searched for… More >

  • Open AccessOpen Access

    ARTICLE

    Short term urgency outcomes following transobturator midurethral sling placement

    Ashley King1, David E. Rapp1,2
    Canadian Journal of Urology, Vol.18, No.4, pp. 5796-5801, 2011
    Abstract Introduction: Research suggests that midurethral sling placement may have a beneficial effect on urgency (U) and urge incontinence (UUI). This study examined short term U/UUI outcomes in patients undergoing TVT-O placement.
    Methods: One hundred patients undergoing TVT-O placement were prospectively assessed using 3 day bladder diary, combined with multiple validated incontinence questionnaires focusing on UUI, U and QoL.
    Results: At 6 week assessment, improvements in daily pad use (2.6 to 0.9) and incontinence episodes (3.6 to 0.7) were seen (p < 0.05, both comparisons). Eighty-two patients reported cure of stress incontinence. Focused outcome scores for UUI improved from… More >

  • Open AccessOpen Access

    ARTICLE

    Cross validation of the prostate cancer radiotherapy late toxicity (PCRT) questionnaire with the expanded prostate cancer index composite (EPIC) instrument

    George Rodrigues1,2, Glenn Bauman1, Varagur Venkatesan1, Belal Ahmad1, Michael Lock1, Tracy Sexton1, David D’Souza1, Larry Stitt2, Somaya Eid1,2
    Canadian Journal of Urology, Vol.18, No.4, pp. 5802-5810, 2011
    Abstract Introduction: A 29-item prostate cancer radiotherapy (PCRT) questionnaire with genitourinary (GU), gastrointestinal (GI), and sexual (S) domains has been previously validated for the assessment of late toxicity health-related quality of life (HRQoL) effects. The study objective was to cross-validate the PCRT domains versus the expanded prostate cancer index composite (EPIC) questionnaire urinary (U), bowel (B), hormonal (H), and S subscales.
    Methods and materials: A single-institution cross-sectional PCRT patient cohort was surveyed. Descriptive and intra- and inter-class correlation coefficient statistics for the various EPIC and PCRT HRQoL domain scores were generated. Univariable and multivariable Cox and logistic regressions… More >

  • Open AccessOpen Access

    ARTICLE

    Urinary continence after radical prostatectomy: the patient perspective

    Franklin E. Kuehhas1, Ralph Naegele1, Elisabeth Eckersberger2, Markus Margreiter1, Ralf Herwig1, Amir Kazzazi2, Bob Djavan2
    Canadian Journal of Urology, Vol.18, No.4, pp. 5811-5818, 2011
    Abstract Introduction: To compare the commonly used 0-1 pad definition of urinary continence for postoperative functional outcome after radical prostatectomy and the correlation with self-reported urinary continence and to determine whether a patient questionnaire can deliver more accurate continence status rates.
    Material and methods: We evaluated a cohort of 873 men who underwent radical prostatectomy (RP) at the General Hospital in Vienna between 1998 and 2006. Patients were surveyed with a questionnaire regarding their postoperative outcome and postoperative urinary incontinence. Baseline and pathological factors were examined to determine whether or not they had an impact on the continence status.
    More >

  • Open AccessOpen Access

    ARTICLE

    Are all multi-targeted tyrosine kinase inhibitors created equal? An in vitro study of sunitinib and pazopanib in renal cell carcinoma cell lines

    Daniel Canter, Alexander Kutikov, Konstantin Golovine, Petr Makhov, Jay Simhan, Robert G. Uzzo, Vladimir M. Kolenko
    Canadian Journal of Urology, Vol.18, No.4, pp. 5819-5825, 2011
    Abstract Objectives: We examined the in vitro cellular effects of the multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and pazopanib on a series of human renal cell carcinoma (RCC) cell lines.
    Methods: The human RCC cell lines 769-P, 786-O, HRC-24, HRC-31, HRC-45, HRC-78, SK-26B, and SK-45 were treated with varying concentrations of sunitinib and pazopanib. Cellular proliferation and cell death were assessed using the CellTiter-Blue Cell Viability Assay and the TUNEL assay, respectively. Effective doses (ED) for inhibition of cellular proliferation or induction of apoptosis were calculated for both sunitinib and pazopanib in each RCC cell line.
    Results: Both… More >

  • Open AccessOpen Access

    ARTICLE

    Chronic prostatitis and small intestinal bacterial overgrowth: effect of rifaximin

    Leonard B. Weinstock1,2, Bob Geng3, Steven B. Brandes4
    Canadian Journal of Urology, Vol.18, No.4, pp. 5826-5830, 2011
    Abstract Introduction: This pilot study determined the efficacy of rifaximin, a gut-directed antibiotic, in reducing chronic prostatitis (CP) and gastrointestinal (GI) symptoms in patients with CP type III. The prevalence of small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS) in patients with CP was also evaluated.
    Materials and methods: Chronic prostatitis patients were recruited and screened for SIBO and IBS using the lactulose breath test (LBT) and Rome II criteria, respectively. Patients with a positive LBT result and Chronic Prostatitis Symptom Index (CPSI) score ≥ 15 received rifaximin 550 mg three times daily for 10 days.… More >

  • Open AccessOpen Access

    ARTICLE

    Intra-tumor Doppler fl ow patterns do not predict malignancy of renal masses in a United States population

    Wayland Hsiao1, Adam B. Shrewsberry1, Kelvin A. Moses1, Mathew Malek-Jones, Deborah Baumgarten2, Viraj A. Master1,3, Kenneth Ogan1
    Canadian Journal of Urology, Vol.18, No.4, pp. 5831-5835, 2011
    Abstract Introduction: Increased use of nephron-sparing surgery has revealed a small but significant percentage of benign tumors. Improved imaging techniques have aided in diagnosis, but are still unable to differentiate benign from malignant tumors. We sought to evaluate whether the intra-tumor Doppler flow pattern could predict the presence of renal cell cancer (RCC).
    Materials and Methods: Standard grayscale ultrasound (US) and Power Doppler ultrasound (PDUS) were performed on 40 patients referred to our clinic for suspicious renal masses diagnosed by CT or MRI from December 2007 to May 2010. PDUS findings were used to classify tumors according to… More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    Thermal injury causing delayed perforation of small bowel after transurethral resection of bladder tumor without evidence of bladder perforation

    Nitya E. Abraham1, Ronald Simon2, Ojas Shah1
    Canadian Journal of Urology, Vol.18, No.4, pp. 5836-5838, 2011
    Abstract Risk of thermal injury to the bowel when utilizing electrocautery at the bladder dome has been reported anecdotally. This is a case report of a 64-year-old man with urothelial carcinoma in situ of the bladder who underwent transurethral resection of bladder tumor at the posterior bladder wall near the dome without evidence of perforation. The postoperative course was complicated by delayed small bowel perforation likely secondary to transmission of thermal energy during fulguration of the resection bed. This injury highlights the need for particular prudence when resecting and fulgurating bladder tumors using monopolar electrocautery, specifi More >

  • Open AccessOpen Access

    RESIDENT’S CORNER

    HDR monotherapy for man with radiotherapy contraindications and prostate cancer

    Andrea Lo1, Robert K. Nam2, D. Andrew Loblaw3,4
    Canadian Journal of Urology, Vol.18, No.4, pp. 5839-5843, 2011
    Abstract There is debate about the optimal management of high risk localized prostate cancer. Initial options include surgery or radiation combined with androgen deprivation therapy. We describe a case of a patient with contraindications to radiotherapywhowasmanagedwithhighdoserate(HDR) brachytherapy as his sole treatment.
    A medically operable patient presented with a T2c N0 M0 Gleason9adenocarcinomawithaninitialPSAof19.9ng/mL. Previously, he had severe ulcerative colitis managed with pancolectomy and a neorectum fashioned from ileum anastomosedbehindhisprostate.Afteranegativeextended lymph node dissection, a HDR brachytherapy implant of 35Gyin5fractionsover3dayswasdelivered.Noandrogen deprivationtherapywasused.Thetreatmentwasextremely welltoleratedintheshortandlongtermwithnosignificant bowel or bladder side effects observed in follow up. After 7 years, his PSA was 0.04 ng/mL.
    The More >

  • Open AccessOpen Access

    HOW I DO IT

    Transrectal implantation of electromagnetic transponders following radical prostatectomy for delivery of IMRT

    Daniel Canter1, Alexander Kutikov1, Eric M. Horwitz2, Richard E. Greenberg1
    Canadian Journal of Urology, Vol.18, No.4, pp. 5844-5848, 2011
    Abstract Surgical treatment for men with localized prostate cancer —open, laparoscopic, or robotically-assisted-- remains one of the therapeutic mainstays for this group of patients. Despite the stage migration witnessed in patients with prostate cancer since the introduction of prostate-specific antigen (PSA) screening, detection of extraprostatic disease at the time of surgery and biochemical recurrence following prostatectomy pose signifi cant therapeutic challenges. Radiation therapy (RT) after radical prostatectomy (RP) has been associated with a survival benefi t in both the adjuvant and salvage setting. Nevertheless, optimal targeting of the prostate bed following surgery remains challenging. The Calypso… More >

  • Open AccessOpen Access

    CLINICAL TRIALS

    Open clinical uro-oncology trials in Canada

    Eric Winquist, George Rodrigues
    Canadian Journal of Urology, Vol.18, No.4, pp. 5849-5855, 2011
    Abstract This article has no abstract. More >

  • Open AccessOpen Access

    CASE REPORT

    Inadvertent cryoablation of exophytic upper tract urothelial carcinoma without pelvicalyceal involvement

    Andrew C. Strine1, David J. Grignon2, Chandru P. Sundaram3
    Canadian Journal of Urology, Vol.18, No.4, pp. 5856-5859, 2011
    Abstract Ablative therapy has recently emerged as an option for the treatment of small renal masses (SRMs). Benign tumors and indolent renal cell carcinoma (RCC) represent a majority of these masses, although an additional but often unappreciated consideration is upper tract urothelial carcinoma (UC). We report the case of a 74-year-old man with upper tract UC presenting as a SRM without any apparent involvement of the pelvicalyceal system, leading to its inadvertent cryoablation. We also discuss the role of renal biopsy in the management of SRMs undergoing an ablative procedure. More >

Per Page:

Share Link