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The role of vitamin D, estrogen, calcium sensing receptor genotypes and serum calcium in the pathogenesis of prostate cancer

Attila Szendroi1, Gabor Speer2, Adam Tabak2,3, Janos P. Kosa2, Peter Nyírády1, Attila Majoros1, Imre Romics1, Peter Lakatos2

1 Semmelweis University, Department of Urology, Budapest, Hungary
2 1st Department of Internal Medicine, Semmelweis University, Budapest, Hungary
3 Department of Epidemiology and Public Health, University College London, London, United Kingdom
Address correspondence to Dr. Attila Szendroi, Department of Urology, Semmelweis University Budapest, Ülloi ut 78/b, Budapest, Hungary, H-1082

Canadian Journal of Urology 2011, 18(3), 5710-5716.

Abstract

Introduction: Prostate cancer is the second leading cause of cancer death among men in developed countries. Estrogen receptor-alpha (ER-α), vitamin D receptor (VDR), and the calcium-sensing receptor (CaSR), partly through their effects on calcium levels are implicated in the proliferation and carcinogenesis in the prostate gland. VDR, ER-α and CaSR genes show polymorphisms in humans that appear to have clinical significance in many pathological conditions, such as prostate cancer. Our aim was to evaluate the role of ER-α (PvuII, XbaI), VDR (BsmI) and CaSR (A986S) gene polymorphisms and serum calcium levels in the pathogenesis of prostate cancer.
Material and methods: Two hundred four patients with prostate cancer and 102 healthy controls were recruited into a hospital-based case control study. After genotyping, the relationship between the individual genotypes and prostate cancer was investigated.
Results: Both the ER-α XbaI and the VDR BsmI polymorphisms were significantly related to the risk of prostate cancer. An age adjusted logistic regression limited to controls and patients not receiving bisphosphonate therapy showed that higher corrected serum calcium and the VDR Bb/BB genotypes independently increased the risk of prostate cancer.
Conclusions: ER-α XbaI and VDR BsmI genetic polymorphisms had a significant association with the risk of prostate cancer. Both VDR BsmI genotypes and serum calcium levels were independently related to the risk of prostate cancer, suggesting an influence of VDR on the development of this malignancy.

Keywords

prostate cancer, vitamin D receptor, estrogen-alpha receptor, calcium-sensing receptor, serum calcium

Cite This Article

APA Style
Szendroi, A., Speer, G., Tabak, A., Kosa, J.P., Nyírády, P. et al. (2011). The role of vitamin D, estrogen, calcium sensing receptor genotypes and serum calcium in the pathogenesis of prostate cancer. Canadian Journal of Urology, 18(3), 5710–5716.
Vancouver Style
Szendroi A, Speer G, Tabak A, Kosa JP, Nyírády P, Majoros A, et al. The role of vitamin D, estrogen, calcium sensing receptor genotypes and serum calcium in the pathogenesis of prostate cancer. Can J Urology. 2011;18(3):5710–5716.
IEEE Style
A. Szendroi et al., “The role of vitamin D, estrogen, calcium sensing receptor genotypes and serum calcium in the pathogenesis of prostate cancer,” Can. J. Urology, vol. 18, no. 3, pp. 5710–5716, 2011.



cc Copyright © 2011 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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