Open Access

RESIDENT’S CORNER

Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis

Scott M. Norberg¹, Michelle Oros¹, Varsha Manucha², Daniel Eun¹, Marijo Bilusic³

1 Temple University Hospital, Philadelphia, Pennsylvania, USA
2 University of Mississippi Medical Center, Jackson, Mississippi, USA
3 Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Address correspondence to Dr. S.M. Norberg, Temple University Hospital, 3401 N Broad Street, Philadelphia, PA 19140 USA

Canadian Journal of Urology 2015, 22(2), 7755-7757.

Abstract

Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.

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