Open Access

ARTICLE

Partial nephrectomy for renal cell carcinoma in long-term renal allografts: operative and postoperative considerations

Ashley Cox, Christopher Y. Nguan, Patrick P. W. Luke

London Health Sciences Centre, London, Ontario, Canada
Address correspondence to Dr. Patrick Luke, London Health Sciences Centre, University Campus, 339 Windermere Road, London, Ontario N6A 5A5 Canada

Canadian Journal of Urology 2005, 12(6), 2887-2890.

Abstract

The majority of immunosuppressive agents used to prevent rejection in transplant patients have also been shown to increase malignancy risk. Renal transplant patients are dependent upon their solitary allograft kidneys in order to remain dialysis free, and the discovery of a primary malignancy within the allograft poses a therapeutic dilemma. We describe two cases of primary renal allograft malignancies and discuss nephron-preserving surgical treatment. Furthermore, we discuss the potential anti-tumor role of the immunosuppressive agent sirolimus in the treatment of these complex patients.

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Keywords

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