Open Access

CASE REPORT

Percutaneous sequential bacillus CalmetteGuèrin and mitomycin C for panurothelial carcinomatosis

Savino M. Di Stasi, Antonella Giannantoni, Robert L. Stephen^*, Luigi Storti, Francesco Attisani, Andrea De Carolis, Guido Virgili

Department of Surgery/Urology, “Tor Vergata” University, Rome; Department Of Urology, University of Perugia, Perugia; Physion Laboratories, Medolla; Italy
* Robert (Bob) L. Stephen leaves us with the memory of an inspiring teacher, scientist, colleague and friend. We sorely miss him.
Address correspondence to Dr. Savino M. Di Stasi, Department of Surgery/Urology, “Tor Vergata” University, Via Torrice 4, 00189 Rome, Italy

Canadian Journal of Urology 2005, 12(6), 2895-2898.

Abstract

A 59 year old male presented with a 4 month history of lower urinary tract symptoms.
Exhaustive urological investigations revealed papillary tumors and carcinoma in situ extending from the prostatic urethra, throughout the bladder, up both ureters and into the renal pelves.
Tumors were resected where possible and then bacillus Calmette-Guèrin (BCG) and mitomycin C (MMC) were infused sequentially through bilateral nephrostomy tubes for a total of six BCG and three MMC instillations.
Follow up 1 month post treatment demonstrated a complete response which persisted for 2 years. Then there appeared a solitary papillomatous recurrence in the bladder which was successfully resected. Side effects were the occasional fever and BCG induced granulomatis prostatitis which slowly resolved.
In conclusion, sequential BCG/MMC instillations were effective treatment for widespread panurothelial carcinomatosis.

---

Keywords

---