Open Access

ARTICLE

Salvage cryosurgical ablation of the prostate for local recurrence after radiation therapy: improved outcomes utilizing a capromab pendetide scan and biopsy algorithm

Harry S. Clarke Jr, Matthew R. Eskridge, Ahmed M. El-Zawahry, Thomas E. Keane

Department of Urology, Medical University of South Carolina, Charleston, South Carolina, USA
Address correspondence to Dr. Harry S. Clarke, Jr., Department of Urology, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB 644, Charleston, SC USA

Canadian Journal of Urology 2007, 14(Suppl.6), 24-27.

Abstract

Purpose: We assessed the efficacy, complications and technical advancements in salvage cryosurgical ablation of the prostate for recurrent prostate cancer after radiation therapy.
Methods: A total of 58 patients were evaluated for salvage cryosurgery using an algorithm of capromab pendetide scan and prostate biopsy from January 2003 to July 2007. Forty-seven patients underwent salvage cryosurgery and biochemical recurrence-free survival and complications were retrospectively reviewed. Mean follow-up was 24 months.
Results: Seventy percent of patients achieved a nadir PSA < 0.5 ng/ml. Overall, 51% of patients achieved a durable PSA response with a pre-salvage serum PSA < 10 predictive of success. There were no major complications and minor complications were few.
Conclusion: Salvage cryotherapy in experienced hands utilizing third-generation technology provides for excellent biochemical control with minimal morbidity.

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