Open Access

CASE REPORT

Salvage paclitaxel chemotherapy for metastatic collecting duct carcinoma of the kidney

Aditya Bagrodia¹, Robert Gold^1,2, Charles Handorf^1,3, Andrew Liman⁴, Ithaar H. Derweesh¹

1 Department of Urology, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA
2 Department of Radiology, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA
3 Department of Pathology, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA
4 University of Tennessee Cancer Institute, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA
Address correspondence to Dr. Ithaar H. Derweesh, Department of Urology, University of Tennessee Health Sciences Center, 910 Madison Avenue, Room 412, Memphis, TN 38163 USA

Canadian Journal of Urology 2008, 15(6), 4425-4427.

Abstract

We report a case of metastatic collecting duct carcinoma (CDC) incidentally found on computer assisted tomography in an 18-year-old male who presented status post a motor vehicle crash (MVC). The patient underwent total nephrectomy/renal vein thrombectomy with retroperitoneal lymph node dissection, followed by multimodal therapy, with gemcitabine and platinum salt therapy, effecting a short lived complete response, followed by single agent paclitaxel chemotherapy effecting a similarly short lived partial response. We conclude that cytoreductive nephrectomy and lymphadenectomy combined with chemotherapy may be useful for extending and increasing the quality of life of selected patients with CDC.

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