Open Access

ARTICLE

Dietary intervention after defi nitive therapy for localized prostate cancer: results from a pilot study

J. Kellogg Parsons^1-3, Vicky A. Newman², James L. Mohler⁴, John P. Pierce², Shirley Flatt², Karen Messer², James Marshall⁴

1 University of California, San Diego Medical Center, San Diego, California, USA
2 Moores Comprehensive Cancer Center, University of California San Diego, La Jolla, California, USA
3 Veterans Affairs San Diego Medical Center, San Diego, California, USA
4 Roswell Park Cancer Institute, Buffalo, New York, USA
Address correspondence to Dr. J. Kellogg Parsons, UCSD Division of Urology, 200 West Arbor Drive, #8897, San Diego, CA 92103-8897 USA

Canadian Journal of Urology 2009, 16(3), 4648-4654.

Abstract

Introduction: Diet has been linked to prostate cancer risk. Dietary modification may inhibit prostate cancer progression.
Materials and methods: As part of a randomized trial, we analyzed the effect of a diet based intervention on 25 prostate cancer patients who had previously undergone surgery or radiation.
Results and conclusions: In the intervention arm, vegetable intake increased (p < 0.05), fat intake decreased (p < 0.05), and mean plasma levels of ß-carotene and total carotenoids increased (p < 0.05). In the control arm, there were no significant changes in diet or blood carotenoids. These data support the feasibility of studying dietary interventions as salvage or adjuvant therapy after surgery or radiation for localized prostate cancer.

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