Open Access

HOW I DO IT

Using darolutamide in advanced prostate cancer: How I Do It

Joelle Hamilton

Urology Centers of Alabama, Homewood, Alabama, USA
Address correspondence to Dr. Joelle Hamilton, Urology Centers of Alabama, 3485 Independence Drive Homewood, AL 35209 USA

Canadian Journal of Urology 2021, 28(3), 10673-10677.

Abstract

Darolutamide is a nonsteroidal androgen inhibitor FDA approved for the treatment of castration-resistant nonmetastatic prostate cancer (nmCRPC). After decades of offering androgen deprivation therapy (ADT) alone or first-generation androgen receptor blockers for patients whose PSA was rising despite castrate levels of testosterone, there are now three different treatment options to add to ADT. These include apalutamide approved in February 2018, enzalutamide FDA approved in June 2018, and darolutamide approved July 2019. Each of these androgen receptor pathway blockers, when added to ADT or surgical orchiectomy, prolongs metastasis-free-survival (MFS) and median survival (MS). This paper focuses on the use of the newest approved agent in this class, darololutmide.

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