Open Access

RESIDENT’S CORNER

Complete pathologic response of bulbar urethral squamous cell carcinoma in situ to topical 5-fluorouracil with urethral milking

Bryce A. Baird¹, Timothy D. Lyon¹, Kevin Wu², Augustus Anderson³, Gregory A. Broderick¹

1 Department of Urology, Mayo Clinic Florida, Jacksonville, Florida, USA
2 Department of Pathology, Mayo Clinic Florida, Jacksonville, Florida, USA
3 School of Medicine, Tulane University, New Orleans, Louisiana, USA
Address correspondence to Dr. Bryce A. Baird, Department of Urology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224 USA

Canadian Journal of Urology 2022, 29(2), 11119-11122.

Abstract

Primary urethral carcinoma is a rare oncologic condition with limited data to support organ-sparing therapies. Herein, we present a case of primary urethral squamous cell carcinoma in situ of the bulbar urethra treated with intraurethral 5-fluorouracil (5-FU) who exhibited a complete pathologic response observed at the time of dismembered urethroplasty. The clinical features, diagnosis, and treatment course of our case are reviewed. These data may support the use of intraurethral 5-FU for similar cases in the future.

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