Table of Content

Open Access iconOpen Access

ARTICLE

Sustained Drug Release from Contact Lenses

J.A.Ferreira2,3, P. Oliveira1, P.M. Silva4, A. Carreira5,3, J.N. Murta6

This work was partially supported by Projects: PTDC/MAT/74548/2006, UTAustin/MAT/0066/2008
CMUC, Department of Mathematics, University of Coimbra, Largo D. Dinis, 3001 - 454 Coimbra, Portugal
Email of the corresponding author: ferreira@mat.uc.pt
Department of Physics and Mathematics, ISEC, Rua Pedro Nunes, Quinta da Nora, 3030-199Coimbra, Portugal
Department of Chemical Engineering, Rua Sílvio Lima, Pólo II, 3030-790 Coimbra Portugal
Department of Ophthalmology, Faculty of Medicine, University of Coimbra, 3001 - 454 Coimbra, Portugal

Computer Modeling in Engineering & Sciences 2010, 60(2), 151-180. https://doi.org/10.3970/cmes.2010.060.151

Abstract

This paper focuses on the release of an ophthalmic drug (flurbiprofen) from a loaded copolymer where the drug is simultaneously dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. In vitro experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.

Keywords


Cite This Article

APA Style
J.A.Ferreira, , Oliveira, P., Silva, P., Carreira, A., Murta, J. (2010). Sustained drug release from contact lenses. Computer Modeling in Engineering & Sciences, 60(2), 151-180. https://doi.org/10.3970/cmes.2010.060.151
Vancouver Style
J.A.Ferreira , Oliveira P, Silva P, Carreira A, Murta J. Sustained drug release from contact lenses. Comput Model Eng Sci. 2010;60(2):151-180 https://doi.org/10.3970/cmes.2010.060.151
IEEE Style
J.A.Ferreira, P. Oliveira, P. Silva, A. Carreira, and J. Murta, “Sustained Drug Release from Contact Lenses,” Comput. Model. Eng. Sci., vol. 60, no. 2, pp. 151-180, 2010. https://doi.org/10.3970/cmes.2010.060.151



cc Copyright © 2010 The Author(s). Published by Tech Science Press.
This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
  • 1272

    View

  • 1067

    Download

  • 0

    Like

Related articles

Share Link