Open Access

REVIEW

Review: negative regulation of leptin receptor signalling

Delphine Lavens, Julie Piessevaux, Jan Tavernier

Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, VIB09, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent
Tel.: (+00 32) 9 264 93 02; fax: (+00 32) 9 264 94 92

* Corresponding Author: J. Tavernier,

European Cytokine Network 2006, 17(3), 211-219. https://doi.org/10.1684/ecn.2006.0040

Accepted 08 September 2006;

Abstract

Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control. Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the various mechanisms that control cellular leptin receptor signalling.

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