Open Access

ARTICLE

TREM-1 interaction with the LPS/TLR4 receptor complex

Rob J. W. Arts¹, Leo A. B. Joosten¹, Charles A. Dinarello^1,2, Bart Jan Kullberg¹, Jos W. M. van der Meer¹, Mihai G. Netea¹

1 Radboud University Nijmegen Medical Center; and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands
2 Division of Infectious Diseases, University of Colorado Health Sciences Center, Aurora, Colorado, USA

* Corresponding Author: M.G. Netea,

European Cytokine Network 2011, 22(1), 11-14. https://doi.org/10.1684/ecn.2011.0274

Accepted 21 January 2011;

Abstract

Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors. In this study, several lines of evidence are presented that TREM-1 interacts with the toll-like receptor 4 (TLR4) receptor complex, or is a component of this complex. Blocking anti-TREM-1 antibodies specifically inhibited LPS-induced TNF-α production, while the alternative approach of blocking TLR4 by a specific inhibitor led to a down-regulation of the effects of TREM-1 cross-linking. These data are in line with the TLR4-TREM1 co-localization in human neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with the TLR4/LPS-receptor complex.

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Keywords

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