Open Access

ARTICLE

The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene is associated with the risk of developing systemic lupus erythematosus in Argentinean patients: a multicenter study

Federico Aranda¹, Silvia Perés Wingeyer¹, Sebastián Andrés Muñoz², Alberto Allievi², Alberto Orden³, Rosana Trobo⁴, Analía Alvarez⁵, Alicia Eimon⁵, Juan Carlos Barreira⁶, Emilce Schneeberger⁷, Judith Sarano⁸, Julio Hofman⁹, Gabriela de Larrañaga¹

1 Laboratorio de Hemostasia y Trombosis, Hospital de Infecciosas Dr. F. J. Muñiz
2 Departamento de Medicina Interna, Hospital General de Agudos Dr. J. A. Fernández
3 Departamento de Medicina Interna, Clínica San Camilo
4 Departamento de Reumatología, Hospital Dr. B Sommer
5 Departamento de Reumatología, Hospital Dr. J. Penna
6 Departamento de Reumatología, Hospital Británico
7 Instituto de Rehabilitación Psicofísica (I.R.E.P)
8 Instituto de Investigaciones Médicas Dr. A. Lanari
9 Departamento de Reumatología, H.I.G.A. E. Perón. Buenos Aires, Argentina

* Corresponding Author: Aranda,

European Cytokine Network 2012, 23(1), 7-11. https://doi.org/10.1684/ecn.2012.0297

Accepted 01 February 2012;

Abstract

Systemic lupus erythematosus (SLE) is a systemic, autoimmune disorder. Monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the recruitment and migration of monocytes/macrophages, has been shown to be increased in the plasma of SLE patients. The aim of our study was to evaluate the possible association of the polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and with other clinical features of SLE in an Argentinean population. A group of 171 SLE patients and 120 control subjects were examined. Genotypic and allelic frequencies of theMCP-1 -2518 A/G polymorphism showed significant differences between the SLE and the control groups (p=0.001 and p=0.01, respectively). However, the polymorphism showed no association with LN or with the other clinical variables studied. Our results suggest that the presence of the MCP-1 -2518 A/G polymorphism might be a risk factor for developing SLE in genetically predisposed individuals, but it does not seem to have a role in the evolution of the disease in the Argentinean population.

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