Open Access

ARTICLE

IL-1β a potential factor for discriminating between thyroid carcinoma and atrophic thyroiditis

Maha Kammoun-Krichen^1,2, Noura Bougacha-Elleuch^1,2, Mouna Mnif^1,3, Fadia Bougacha⁴, Ilhem Charffedine⁵, Sandra Rebuffat^1,6, Ahmed Rebai⁴, Emilie Glasson⁷, Mohamed Abid³, Fatma Ayadi⁸, Sylvie Péraldi-Roux^1,6, Hammadi Ayadi^1,2

1 LIA135 CNRS
2 Unité cibles pour le diagnostique et la thérapie, centre de biotechnologie de Sfax, Sfax, Tunisie
3 Service d’endocrinologie, CHU Hedi-Chaker, Sfax, Tunisie
4 Unité de bioinformatique, centre de biotechnologie de Sfax, Sfax, Tunisie
5 Service d’ORL, CHU Habib-Bourguiba, Sfax, Tunisia
6 Centre de pharmacologie et innovation dans le diabète (UMR5232) Montpellier, France
7 Sysdiag UMR-CNRS 5160, Montpellier, France
8 Service de biochimie, CHU Habib-Bourguiba, Sfax, Tunisie

* Corresponding Author: Maha Kammoun-Krichen,

European Cytokine Network 2012, 23(3), 101-106. https://doi.org/10.1684/ecn.2012.0312

Accepted 20 April 2012;

Abstract

Interactions between cytokines and others soluble factors (hormones, antibodies...) can play an important role in the development of thyroid pathogenesis.The purpose of the present study was to examine the possible correlation between serum cytokine concentrations, thyroid hormones (FT4 and TSH) and auto-antibodies (Tg and TPO), and their usefulness in discriminating between different thyroid conditions. In this study, we investigated serum from 115 patients affected with a variety of thyroid conditions (44 Graves’ disease, 17 Hashimoto’s thyroiditis, 11 atrophic thyroiditis, 28 thyroid nodular goitre and 15 papillary thyroid cancer), and 30 controls. Levels of 17 cytokines in serum samples were measured simultaneously using a multiplexed human cytokine assay. Thyroid hormones and auto-antibodies were measured using ELISA. Our study showed that IL-1β serum concentrations allow the discrimination between atrophic thyroiditis and papillary thyroid cancer groups (p = 0.027).

---

Keywords

---