Open Access

ARTICLE

Evaluation of insulin resistance and plasma levels for visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome

Ozen Oz Gul¹, Soner Cander², Bulent Gul³, Ebru Açıkgoz⁴, Emre Sarandol⁴, Canan Ersoy¹

1 Uludag University Medical School, Department of Endocrinology and Metabolism, Bursa, Turkey
2 Sevket Yilmaz Education and Reserach Hospital, Department of Endocrinology and Metabolism, Bursa, Turkey
3 Sevket Yilmaz Education and Reserach Hospital, Department of Nephrology, Bursa, Turkey
4 Uludag University Medical School, Department of Biochemistry, Bursa, Turkey

* Corresponding Author: Ozen Oz Gul,

European Cytokine Network 2015, 26(4), 73-78. https://doi.org/10.1684/ecn.2015.0370

Abstract

This study was designed to evaluate insulin resistance and plasma levels of visfatin and resistin in obese and non-obese patients with polycystic ovary syndrome (PCOS).A total of 37 premenopausal PCOS patients with (n = 18, mean (SD) age: 27.5 (5.7 years) or without obesity (n = 19, mean (SD) age: 23.7 (3.1) years) and healthy volunteers (n = 18, mean (SD) age:29.8 (4.1) years) were included in this study. Data on clinical characteristics, glycemic parameters and lipid parameters were recorded for each subject as were plasma visfatin and resistin levels. Mean (SD) HOMA-IR values were significantly higher in obese PCOS patients (3.4 (1.7)) compared with non-obese PCOS patients (2.0 (1.2), p<0.01) and controls (1.6 (0.8), p<0.01). No significant difference was noted between study groups in terms of plasma resistin (ng/mL) or visfatin (ng/mL) levels. There was no correlation between serum plasma visfatin (r = 0.127, p = 0.407) and resistin (r = -0.096, p = 0.544) levels and HOMA-IR. In conclusion, our findings revealed increased likelihood of metabolic and dyslipidemic manifestations in obese compared to non-obese PCOS patients, while no significant difference was noted in visfatin and resistin levels among PCOS patients in terms of co-morbid obesity and in comparison to controls.

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