Open Access

REVIEW

Pulmonary artery hypertension: pertinent vasomotorial cytokines

Shi-Min Yuan

Department of Cardiothoracic Surgery, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian 351100, Fujian Province,People’s Republic of China

* Corresponding Author: Shi-Min Yuan,

European Cytokine Network 2017, 28(1), 1-7. https://doi.org/10.1684/ecn.2016.0386

Accepted 15 December 2016;

Abstract

Pulmonary artery hypertension is a syndrome that shows similar clinical and pathophysiological features characterized by elevated pulmonary arterial pressure and resistance. There have been a series of hypotheses trying to describe the development of pulmonary artery hypertension; however, none of them perfectly explains its pathogenesis. To highlight the pathogenesis, novel vasomotorial cytokines including hypoxia-inducible factor-1α endothelin-1, urotensin II, Krüppel-like factor 4, calcitonin gene-related peptide, angiopoietins and serotonin closely related to pulmonary artery hypertension are discussed. The development of the new agents relating to these cytokines may improve the relevant treatment strategies.

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Keywords

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