Open Access

REVIEW

Zika virus in the eye of the cytokine storm

Christopher Maucourant^1,a, Gabriel Andrade Nonato Queiroz^2,3,a, Assia Samri¹, Maria Fernanda Rios Grassi^2,3, Hans Yssel¹, Vincent Vieillard¹

1 Sorbonne Universite´s, UPMC Univ Paris 06, INSERM U1135, CNRS ERL8255, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), Paris, France
2 Advanced Laboratory of Public Health/IGM–Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falca˜o, no 121, Candeal, Salvador, Bahia CEP 40296-710, Brazil
3 Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil

* Corresponding Author: V. Vieillard,
a Co-first authors.

European Cytokine Network 2019, 30(3), 74-81. https://doi.org/10.1684/ecn.2019.0433

Abstract

Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barre´ syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. Over the five past years, through the combined efforts of the scientific community, comprehensive remarkable progress aimed at deciphering the clinical, virological, physiopathological, and immunological features of ZIKV infection. This review highlights some of the most recent advances in our understanding of the role of cytokines and chemokines in ZIKV infection, and discusses potential links to pathogenesis.

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Keywords

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