Open Access

REVIEW

Christopher Maucourant^1,a, Gabriel Andrade Nonato Queiroz^2,3,a, Assia Samri¹, Maria Fernanda Rios Grassi^2,3, Hans Yssel¹, Vincent Vieillard¹
European Cytokine Network, Vol.30, No.3, pp. 74-81, 2019, DOI:10.1684/ecn.2019.0433
Abstract Zika virus (ZIKV) is an emerging arbovirus that causes a mosquito-borne disease. Although infection with ZIKV generally leads to mild disease, its recent emergence in the Americas has been associated with an increase in the development of the Guillain-Barre´ syndrome in adults, as well as with neurological complications, in particular congenital microcephaly, in new-borns. Over the five past years, through the combined efforts of the scientific community, comprehensive remarkable progress aimed at deciphering the clinical, virological, physiopathological, and immunological features of ZIKV infection. This review highlights some of the most recent advances in our understanding More >

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ORIGINAL ARTICLE

Maryam Zarrabi¹, Nasser Gholijani¹, Saeedeh Shenavandeh², Elham Aflaki², Zahra Amirghofran^1,3
European Cytokine Network, Vol.30, No.3, pp. 82-87, 2019, DOI:10.1684/ecn.2019.0430
Abstract Behcet’s disease (BD) is a chronic multisystem autoimmune disorder. Various cytokines take part in the pathogenesis of this disease. Interleukin (IL)-38, a new member of IL-1 cytokine family, has been reported to have antiinflammatory properties; however, its role in BD has not been investigated yet. In this study, we aimed to examine the probable role of IL-38 in the clinical context of BD. A total of 81 patients with BD and 81 age- and sex-matched healthy subjects as controls were included in this study. The serum levels of IL-38 were measured in patients and controls… More >

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ORIGINAL ARTICLE

Yuan Zhao, Gao-Yin Kong, Wan-Min Pei, Bo Zhou, Qin-Qin Zhang, Bing-Bing Pan
European Cytokine Network, Vol.30, No.3, pp. 88-97, 2019, DOI:10.1684/ecn.2019.0431
Abstract Background: Dexmedetomidine (Dex), frequently used as an effective sedative, was reported to play a critical role in the protection of multiple organs. However, its underlying mechanism of a putative protective effect on ischemia/reperfusion (I/R)-induced liver injury is still unclear. Methods: A hepatocyte injury model was established by treating WRL-68 cells with oxygen and glucose deprivation/reoxygenation (OGD/R). Enzyme Linked Immunosorbent Assay (ELISA) kits were used to determine the level of inflammatory factors (IL-6, IL-1β, and TNF-α), and oxidative stress indicators (ROS, MDA, GSH-Px, and SOD). MTT assay and flow cytometry analysis were used to determine the… More >

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ORIGINAL ARTICLE

Si-Si Jin¹, Xian-Fan Lin¹, Ju-Zeng Zheng¹, Qiong Wang², Hua-Qin Guan¹
European Cytokine Network, Vol.30, No.3, pp. 98-106, 2019, DOI:10.1684/ecn.2019.0432
Abstract Background: As one of the most common liver disorders worldwide, nonalcoholic fatty liver disease (NAFLD) begins with the abnormal accumulation of triglyceride (TG) in the liver and can lead to inflammation and fibrosis. Long noncoding RNA (lncRNA) NEAT1 was reported to promote NAFLD progress. However, its molecular mechanism in NAFLD was not fully clear. Method: In vitro cellular model of NAFLD was established with BRL3A cell treated by free fatty acid (FFA). Cell Counting Kit-8 (CCK-8) assay was carried out to assess cell proliferation. The expression of mRNA and protein of inflammation and fibrosis in BRL3A… More >

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ORIGINAL ARTICLE

Yasser Bagheri^1,2,3, Fateme Babaha⁴, Reza Falak^1,2, Reza Yazdani³, Gholamreza Azizi⁵, Maryam Sadri¹, Hassan Abolhassani^3,6, Mehdi Shekarabi^1,2, Asghar Aghamohammadi³
European Cytokine Network, Vol.30, No.3, pp. 107-113, 2019, DOI:10.1684/ ecn.2019.0434
Abstract Background: Interleukin-10 (IL-10) is a pleiotropic cytokine, which has both regulatory and stimulatory effects on different immune cell types. Different studies have reported the importance of IL-10 and Transforming growth factor-beta (TGF-β) in the regulation of B cell class switching the production of immunoglobulin A (IgA); however, the underlying mechanisms remain to be fully elucidated. The objective of this study was to investigate the TGF-β response during B stimulation of human B cells by IL-10. Methods: Pan B cells of healthy donors were negatively purified by a magnetic cell separation technique. B cells were cultured… More >

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