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REVIEW

Zahra Ebrahim Soltani^1,2, Farzaneh Rahmani^1,2, Nima Rezaei^2,3
European Cytokine Network, Vol.30, No.1, pp. 1-14, 2019, DOI:10.1684/ecn.2019.0424
Abstract Guillain-Barré syndrome (GBS) is the most common cause of acute paralysis in the United States. Campylobacter jejuni is a common trigger for GBS, igniting autoimmunity as a result of molecular mimicry between C. jejuni lipooligosaccharide (LOS) and host gangliosides. Evidence also suggests an active role for cell-mediated and innate immunity in pathogenesis of GBS. Infection alone is not enough for GBS to develop, infection with the same strain might yield different outcomes in different patients. C. jejuni strains with low to absent molecular mimicry to self-antigens can cause full-blown GBS with positive autoantibodies. A role for T helper More >

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ARTICLE

Roba M. Talaat¹, Hiba Sibaii², Iman H. Bassyouni³, Amany El-Wakkad⁴
European Cytokine Network, Vol.30, No.1, pp. 15-22, 2019, DOI:10.1684/ecn.2019.0421
Abstract There are a limited number of studies that report the polarization of the immune system toward the production of T helper 1 (Th1), Th2, or Th17-type cytokines in patients with Behçet’s disease (BD). Here, we aimed to detect the presence of various cytokines in serum samples of Egyptian BD patients and to determine the correlation between their production levels and clinical manifestations. To that aim, serum levels of IFN-γ, IL-10, IL-6, and IL-17 measured by ELISA were determined in BD patients with active or inactive disease to evaluate their clinical relevance. The results of the… More >

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Chul Soo Park¹, Hye Young Moon², Sangbin Han², Jin Young Chon², Min Suk Chae¹, Sang Hyun Hong¹, Jong Ho Choi¹, Hyun Sik Chung¹
European Cytokine Network, Vol.30, No.1, pp. 23-28, 2019, DOI:10.1684/ecn.2019.0422
Abstract Recipient’s immune responses are an important factor in allograft survival in transplantation. Cytokines are reflected with immune responses. In the present study, we aimed to evaluate potential affecting factors of liver allograft survival and their possible correlation with seroum cytokine levels in living donor liver transplantation (LDLT). One hundred and seventy-one adult patients’ data were collected retrospectively. Five cytokines were collected: interferon (IFN)-γ, interleukin (IL)-2, IL-10, IL-6, and IL-17. Ischemic time of liver grafts was divided into two periods: cold and warm ischemic times (CIT and WIT, respectively). CIT had no statically significant correlation, but… More >

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Ayse Ekin Kara¹, Gurhan Guney^1,2, Aytekin Tokmak¹, Gulnur Ozaksit¹
European Cytokine Network, Vol.30, No.1, pp. 29-33, 2019, DOI:10.1684/ecn.2019.0423
Abstract Objective: The aim of our study was to evaluate serum high-sensitivity C-Reactive Protein (hs-CRP), sialic acid (SA), and interleukin-6 (IL-6) levels in pregnancies complicated with preeclampsia (PE) and intrauterine growth restriction (IUGR) and to compare with healthy pregnancies. Materials and Methods: This study was conducted at a tertiary-level maternity hospital with 80 pregnant women. Fasting blood samples were taken from 44 consecutive women with pregnancies complicated by PE (n: 20) and IUGR (n: 24), and 36 were from normal pregnancies. Serum hs-CRP, SA, and IL-6 concentrations were measured in all participants. Results: Serum mean hs-CRP,… More >

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Fugang Li¹, Li Liu^2,a, Xiaolan Guo¹, Zhigang Luo¹, Yong Zhang², Feng Lu¹, Gang Wang¹, Tao Chen¹, Dezheng Chen²
European Cytokine Network, Vol.30, No.1, pp. 34-38, 2019, DOI:10.1684/ecn.2019.0425
Abstract Objective: This study mainly to explore the change of serum cytokines in wasp sting patients and the potential correlation between cytokines and acute kidney injury (AKI) due to wasp stings. Methods: The levels of IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ in 33 wasp sting and 24 healthy people were measured by flow cytometry, the level of IL-17 was detected by enzyme-linked immunosorbent assay and the laboratory examination including inflammatory indicators, muscle enzyme markers, and renal function were detected by automatic biochemical analyzer, blood analyzer, and urine analyzer. The wasp sting patients were divided into… More >

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