Open Access

ORIGINAL ARTICLE

Yasser Bagheri^1,2,#, Mohsen Saeidi^1,2,#, Reza Yazdani^3,4, Fateme Babaha³, Reza Falak^5,6, Gholamreza Azizi⁷, Marjan Taherian^5,6, Fereshteh Salami³, Yaghoob Yazdani^1,2, Somayeh Sadani⁸, Ali Hosseini⁸, Morteza Motallebnezhad^5,6, Hassan Abolhassani^3,9, Mehdi Shekarabi^5,6, Asghar Aghamohammadi³
European Cytokine Network, Vol.33, No.1, pp. 1-12, 2022, DOI:10.1684/ecn.2021.0464
Abstract Background: Selective IgA deficiency is the most prevalent form of primary immunodeficiencies. The pathogenesis of the disease is still unknown. Several studies have suggested a defect in B cell responses to IL-10; however, the main reason for this defect has not been reported. Elucidating IL-10 signaling defects and their correlation with clinical manifestations could be helpful for better understanding and treatment of the disease. Methods: In this study, 15 SIgAD patients and 15 age- and sex-matched healthy controls were included. Surface expression of transforming growth factor β receptor II (TGF-β RII), IL-10R and IgA was… More >

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Open Access

ARTICLE

Chuanjun Huang^1,2, Yan Sun², Na Liu², Ziping Zhang¹, Xiyan Wang², Degan Lu², Ling Zhou^2,a, Caiqing Zhang^3,a
European Cytokine Network, Vol.33, No.1, pp. 13-24, 2022, DOI:10.1684/ecn.2021.0476
Abstract Background: Asthma is an airway disease characterized by airflow limitation and various additional clinical manifestations. Repeated inflammatory stimulation of the airways leads to epithelial-mesenchymal transition (EMT) which aggravates subepithelial fibrosis during the process of airway remodelling and enhances resistance to corticosteroids and bronchodilators in refractory asthma. There is growing evidence that IL-27 modulates airway remodelling, however, the molecular mechanisms involving IL-27 and EMT are poorly understood. The objective of this study was to investigate the effects of IL-27 on ovalbumin (OVA)-challenged asthmatic mice in vivo and TGF-β1-induced EMT in 16HBE cells in vitro. METHODS: Airway inflammation, mucus… More >

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