Antibodies as tools in cytokine discovery and usage for diagnosis and therapy of inflammatory diseases
Jo Van Damme1,$, Ghislain Opdenakker2,$, Sam Van Damme3, Soffe Struyf1
European Cytokine Network, Vol.34, No.1, pp. 1-9, 2023, DOI:10.1684/ecn.2023.0484
Abstract Polyclonal antisera from patients have been at the basis of the description of autoimmune diseases and today monoclonal antibodies are widely used in the therapy of cancer and many inflammatory diseases. How antisera and antibodies in combination with traditional in vitro and in vivo biological test systems have been instrumental reagents for the discovery of new cytokines is illustrated here for interleukin-1, -6 and -8. Furthermore, widely used immunological detection/quantification systems, such as ELISAs and multiplex assays, based on the use of either polyclonal or monoclonal antibodies, are often fraught with misinterpretations, because the results are affected More >
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